In a 2025 #ScienceSignaling Review, researchers discussed an emerging body of research on the metabolic effects of sleep loss, which disrupts the natural balance of energy within neurons.
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#ScienceSignaling
Latest posts tagged with #ScienceSignaling on Bluesky
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Posts tagged #ScienceSignaling
The emergence of AI tools is not only helpful in cancer #neuroscience, but may be a necessary step to decode the highly complex networks that connect cancer cells to the nervous and immune systems, researchers argue in a new #ScienceSignaling Focus. https://scim.ag/3P61s6j
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New work in #ScienceSignaling exploits long noncoding RNAs in the “dark transcriptome” that possess anti-inflammatory properties by reengineering them to dampen acute inflammation in mice—a finding that could open a new field of lncRNA-based therapies.
📄: scim.ag/40o7kKs
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New work in #ScienceSignaling exploits long noncoding RNAs in the “dark transcriptome” that possess anti-inflammatory properties by reengineering them to dampen acute inflammation in mice—a finding that could open a new field of lncRNA-based therapies. https://scim.ag/4lm6wiY
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Don’t miss the new issue of #ScienceSignaling!
Scientists exploit the dark transcriptome to generate one of the first potential lncRNA therapies, a Focus discusses how AI is becoming a necessary tool to decode the mysteries of cancer neuroscience, and more.
scim.ag/4bi4snt
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The image depicts a liposome containing RNA molecules.
Don’t miss the new issue of #ScienceSignaling!
Scientists exploit the dark transcriptome to generate one of the first potential lncRNA therapies, a Focus discusses how AI is becoming a necessary tool to decode the mysteries of cancer neuroscience, and more. https://scim.ag/4rmyIDy
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How does neuroinflammation trigger depressive-like behaviors?
Researchers in #ScienceSignaling show that Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors.
Learn more: scim.ag/3OdXY1c
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In #ScienceSignaling, a team of scientists devises a method to extend the time that individual molecules can be tracked in a cell, widening the analysis window from several seconds to more than one hour. https://scim.ag/3OGClH4
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How does #neuroinflammation trigger depressive-like behaviors?
Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ
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Researchers have shown how the metabolism of glucose drives colorectal cancer by activating a growth-fueling signaling pathway—and shown that targeting this pathway can shrink tumors in mice.
Learn more in #ScienceSignaling during #ColorectalCancerAwarenessMonth: scim.ag/4rbJAUF
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Researchers in #ScienceSignaling have shown how the metabolism of glucose drives #ColorectalCancer by activating a growth-fueling signaling pathway—and shown that targeting this pathway can shrink tumors in mice. https://scim.ag/4aMsGr1 #ColorectalCancerAwarenessMonth
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The image shows a colored scanning electron micrograph of part of a human colon cancer cell.
The new issue of #ScienceSignaling has arrived!
A hyperactive signaling pathway presents a new target in colorectal cancer, a new imaging technique extends the tracking of single molecules from seconds to an hour, and more. https://scim.ag/4b17hJg
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A new #ScienceSignaling study offers insights into the KOLF2.IJ cell line, which is derived from induced pluripotent stem cells and has been proposed as a neuronal model for Alzheimer’s disease and related #dementia research. https://scim.ag/4aFNY9O
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What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision.
Learn more: https://scim.ag/4s82e0N
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Scientists show that the metabolite acetate enhances the formation of long-term memories in female mice, revealing a previously unknown sex difference in the epigenetic mechanisms that support memory formation.
Learn more in #ScienceSignaling: scim.ag/4su9uEz
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Researchers in #ScienceSignaling show that the metabolite #acetate enhances the formation of long-term memories in female mice, revealing a previously unknown sex difference in the epigenetic mechanisms that support memory formation. https://scim.ag/4cLA6vS
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Scientists discover memory-enhancing properties of acetate unique to female mice, a new Review explores the latest discoveries about metabolic reprogramming after traumatic nerve injury, and more this week in #ScienceSignaling.
scim.ag/40qwjg9
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It's been an honor to lead this work & its development from start to end. I extend my deepest appreciation to my co-authors and their invaluable dedication & contributions.
I hope this work is enjoyed by & sparks scientific curiosity for its readers✨ #neuroepigenetics #ScienceSignaling @science.org
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The image is a colored transmission electron micrograph of a section through a myelin (red)-ensheathed nerve axon (blue), which is regenerating within a Schwann cell (light brown) located within the basement membrane (pink) of an old Schwann cell.
Scientists discover memory-enhancing properties of acetate unique to female mice, a new Review explores the latest discoveries about metabolic reprogramming after traumatic nerve injury, and more this week in #ScienceSignaling. https://scim.ag/4qWS0PU
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A new in vitro study in #ScienceSignaling demonstrates the mechanism of activation for adhesion G protein-coupled receptors (#AGPCRs), which are found in every organ system and are involved in cell adhesion or cell-cell interactions. https://scim.ag/4rWUMW2
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A calcium channel named Orai1 present in immune cells called #microglia may explain how neuroinflammation can induce depressive-like behaviors, according to new experiments in mice published in #ScienceSignaling. https://scim.ag/4rmJSZQ
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The 17 February 2026 cover of Science Signaling. The image shows LPS-induced increases in labeling for a microglial marker (red) or an astrocyte marker (green) in the CA1 region of the hippocampus, effects not seen in mice lacking Orai1 in microglia.
The new issue of #ScienceSignaling has arrived!
Research in mice shows how microglia can trigger depressive-like behaviors linked to neuroinflammation, in vitro work reveals that adhesion GPCRs aren’t activated by corticosteroids, and more. https://scim.ag/3MAVsl5
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The images show the structures of CD25-containing complexes without (top) or with (bottom) CD25 phosphorylation.
The new issue of #ScienceSignaling has arrived!
https://scim.ag/4abpYeg
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Through systems immunology analysis, a team has identified potential therapeutic targets for the treatment of #UlcerativeColitis, an inflammatory bowel disease characterized by dysregulated cytokine signaling in the GI tract. #ScienceSignaling https://scim.ag/4cdvxdv
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Scientists have discovered how cells from the fetus could activate maternal natural killer cells during early pregnancy, helping to demystify the poorly understood mechanisms that govern immune cells at the maternal-fetal interface.
Learn more in #ScienceSignaling: scim.ag/4bvbY03
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Scientists have discovered how cells from the fetus could activate maternal natural killer cells during early pregnancy, helping to demystify the poorly understood mechanisms that govern immune cells at the maternal-fetal interface. #ScienceSignaling https://scim.ag/4bSDXaj
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This week’s new issue of #ScienceSignaling has arrived!
A study reveals how fetal cells could activate maternal natural killer cells during early pregnancy, systems immunology reveals cytokine targets in ulcerative colitis, and more.
scim.ag/4klazvw
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The image is a colored scanning electron micrograph of an NK cell.
This week’s new issue of #ScienceSignaling has arrived!
A study reveals how fetal cells could activate maternal natural killer cells during early pregnancy, systems immunology reveals cytokine targets in ulcerative colitis, and more. https://scim.ag/4tkFgFa
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New in #ScienceSignaling 👉Importin β1 has an unexpected role in presynaptic long-term plasticity and spatial memory, by regulating local protein synthesis at hippocampal synapses.
#neuroscience #cellbiology #synapticplasticity #memory
www.science.org/doi/10.1126/...
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A new study suggests that the “softening” of cancer cells that occurs in some malignant tumors may help the cells to evade antitumor immune defenses.
Learn more in #ScienceSignaling: https://scim.ag/3MaX9W5
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