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Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.

Novel study reveals that IgM drives airway hyperresponsiveness in allergic asthma via the Baiap2l1 pathway in human airway smooth muscle, uncovering a novel target for future therapies 💊

#Immunology #asthma #Th2

🔗 doi.org/10.7554/eLif...

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Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione
synthesis to prevent #ferroptosis and
support #lipid metabolism and expansion of type 2 immune cells in #asthma.

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📰New & Featured | A #Science #Immunology study reveals why #RSV infection in infancy boosts #asthma risk, especially in kids of allergic moms.
🔹RSV → ↑ #FcγR on neonatal DCs
🔹Maternal IgG → enhanced allergen uptake
🔹Synergy drives strong #Th2 priming & asthma traits

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Fantastic start to #BSI25 with @profjudiallen.bsky.social ; a masterclass in scientific storytelling. Her career journey was engaging and full of long-view perspectives. Loved her celebration of mentees, and the message to chase those exciting “distractions” in science. #macrophage #Th2 #infections

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ToHeart2 XRATED版のミニゲーム「ドキドキぱにっくライブラリ」のデータに、使われていなさそうな画像が2枚ありました。

Two (presumably) unused images sitting in the data files of ToHeart2 XRATED's minigame "ドキドキぱにっくライブラリ".

#TH2 #ToHeart2 #AQUAPLUS

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Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.

Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation!
#asthma #immunometabolism

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This month’s cover features an adult female Hpb in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.

This month’s cover features an adult female Hpb in the center, flanked by adult Hpb males with their characteristic caudal bursae on the left and right sides, crescent-shaped Hpb larvae from various stages surrounding the adults, and Hpb eggs in the four corners of the image.

The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation!

bit.ly/SI_DEC_24

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Drs Shahid Karim, Juan Leyva-Castillo & Sukanya Narasimhan review #tick #salivary #glycans – a sugar-coated tick bite.
@theticklab
@YaleMed
@YaleIMed
@SouthernMiss
@harvardmed
@BostonChildrens
#Saliva #αGal #Syndrome #Glycosylation #Th2
doi.org/10.1016/j.pt...

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Les télécoms c'est aussi des tuyaux #TH2 #FrNog23

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En même temps, #TH2 ça ressemble plutôt à un éternuement.

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"If I'm going to have a past, I prefer it to be multiple choice." -Joker, Killing Joke as prep for transmedia storytelling ;) #th2

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For webisodes, make the stakes really high to sustain act breaks every 3 minutes -Jane Espenson #th2

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Oh hey. One of MY pieces made it into Henry's slides. #TH2

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Craig Relyea of Disney Interactive says he's not sure if they could do Kingdom Hearts now that they are no longer under the radar. #TH2

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It's not UGC. It's about empowering the fans and giving them ownership #th2

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"Sonuvabitch" #TH2

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At lunch here at #TH2 they handed us a map. "Oh great," thought I, "a food ARG."

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Sad no one is talking about how transmedia strategies can lead to multiple perspectives on a story world. #TH2

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Hashtag for the conference announced. #TH2

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