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Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation - Scientific Reports Scientific Reports - Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation

clinical trial simulations to optimise analysis strategies for multiple endpoints highlight the trade-off between statistical efficiency and interpretability
#ttvguide

www.nature.com/articles/s41...

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Predictive Value of TTV Viral Load for BKPyV DNAemia Depends on BKPyV-Specific Humoral Immunity in KTRs Neutralizing antibodies (NAbs) have been proposed as biomarkers for stratifying BKPyV replication risk, while TTV viral load is recognized as a globalโ€ฆ

Torque Teno Virus ๐Ÿฆ 
ads to SOC to predict BK viraemia

๐Ÿฆ  can be ๐Ÿฆธโ€โ™€๏ธ #ttvguide

www.sciencedirect.com/science/arti...

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Torque Teno Virus Loads and Leukocyte Populations in Stable Outpatient Solid Organ Transplant Recipients Dosing immunosuppressive medication after solid organ transplantation remains a challenge, with no established marker of immune function available for routine clinical use. Torque teno virus (TTV), a ...

Associations between #TTV and Leukocyte Populations in Solid Organ Transplant Recipients - Partners in The Netherlands provide evidence to support the theory that TTV replicates in immature granulocytes. www.ijidonline.com/article/S120... #TTVguide

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BTS Autumn Symposium - British Transplantation Society The Fundamentals of Transplantation: A Joint Educational Event by The Herrick Society of Trainees in Transplant Surgery & The British Transplant Physician Trainees

thanks ๐Ÿ™ BTS for the invitation!
what a warm welcome to london ๐Ÿ‡ฌ๐Ÿ‡ง

I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT

bts.org.uk/bts-autumn-s...

#TTVguide

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Immune Monitoring Goes Viral ๐Ÿฆ  Torque Teno Virus
for Immunologic Risk Stratification After Kidney Transplantation

โฉ๏ธ new review in TI ๐Ÿ”ฅ

doi.org/10.3389/ti.2...
#ttvguide

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Statistical analysis plan for TTVguideITโ€”a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno... Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...

can viruses ๐Ÿฆ  be superheroes ๐Ÿฆธโ€โ™‚๏ธ ?

PhD student Felix Herkner just published the statistical analysis plan
of the TTVguideIT trial ๐Ÿ’ช๐Ÿ‘

Torque Teno virus guided immunosuppression #TTVguide

data cleaning until Q1/26
analysis Q2/26

trialsjournal.biomedcentral.com/articles/10....

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viruses ๐Ÿฆ  can be superheroes ๐Ÿฆธโ€โ™€๏ธ

Felix Herkner present
the statistical analysis plan
of the TTVguideIT trial
at the Austrian Transplant Congress

Torque Teni Virus guided immunosuppression #TTVguide

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happy to speak about TT virus ๐Ÿฆ  @Italien ๐Ÿ‡ฎ๐Ÿ‡น micro biology congress

TTV based immune monotoring
#TTVguide

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Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Viennaโ€™s Childrenโ€™s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide

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I had great fun at kids university @meduniwien.ac.at today ๐Ÿ˜

viruses ๐Ÿฆ  can be superheroes ๐Ÿฆธโ€โ™€๏ธ

๐Ÿ™ @sebastiankaps.bsky.social
and @fredhaupenthal.bsky.social for your support

#ttvguide

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๐Ÿ—ž๏ธ New paper out: Detection of non-intact Torque Teno viral particles. Partners in Italy have analysed the added value of PMAxxโ„ข treatment to detect non-intact Torque Teno viral particles which may overestimate viremia quantified by digital droplet PCR. #TTV #TTVguide www.mdpi.com/1422-0067/26...

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Among the ESOT2025 highlights: Gregor Bondโ€˜s talk on biomarkers to guide the personalisation of the management of organ recipients! State of the art & future to doโ€™s to move the field forward! Results from the recently completed TTV-Guide RCT project loading soon! #ttvguide ๐Ÿงฌ@gregorbond.bsky.social

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Our team around @gregorbond.bsky.social recently participated at #ESOT2025 - here's our most important learnings: ๐Ÿ”ธ More & more groups worldwide pick up the idea of TTV-guided immunosuppression. ๐Ÿ”ธ First data on the association between TTV load & the development of malignomes is available. #ttvguide

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the highly prevalent and apathogenic TorqueTeno virus ๐Ÿฆ 
is associated with immunosuppression ๐Ÿ’Š

Carsten Herz presents first data on the predicive value of malignancy post kidney transplant
#TTVguide

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Great session on the application and implementation of new technolgy in post-transplant care including @gregorbond.bsky.social on the value of biomarker-guided personalisation

We need more RCTs as the #ttvguide study ๐Ÿฆ ๐Ÿ™

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#ESOTCongress 2025 London ๐Ÿ‡ฌ๐Ÿ‡ง action at the eposters
Torque Teno virus ๐Ÿฆ 
for the prediction of Infection post kidney TX
first long term data
#TTVguide

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happy ๐Ÿ˜Š meeting you
@ #ESOTcongress
this Monday 1.7.
in London ๐Ÿ‡ฌ๐Ÿ‡ง

talks ๐Ÿ—ฃ๏ธ on Torque Teno virus ๐Ÿฆ  guided immunosuppression ๐Ÿ’Š

09:30 and 11:00 room S1
13:15 room S5, 16:15 room S4

#ttvguide

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meet me at #ESOTcongress in London ๐Ÿ‡ฌ๐Ÿ‡ง

๐Ÿ—“๏ธ July 1, 13:00-14:00, ROOM s5

to discuss Torque Teno virus ๐Ÿฆ  based immunologic monotoring

viruses ๐Ÿฆ  can be superheroes ๐Ÿฆธ

#ESOT2025 #TTVguide #ESOT

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Plan your #ESOTcongress agenda with our symposium sessions!

๐Ÿ—“๏ธ July 1, 13:00-14:00, ROOM s5.

Three world-renowned doctors & engaging discussion.
- Dr. John Friedewald @jfriedo.bsky.social
- Dr. Pedro Ventura
- Dr. Gregor Bond @gregorbond.bsky.social

#ESOT2025 #TTVguide #immunosupression #ESOT

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#TTV spreading to #Rheumatology. Currently happening at #EULAR2025. @pstudenic.bsky.social #TTVguide

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this will be fun!
#TTVguide

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congrets to Katharina Mayer receiving the young investigator award @ #ERA25 ๐Ÿ‘

how do TX baseline and fup data influence TT virus ๐Ÿฆ  load?
#TTVguide

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torque teno virus ๐Ÿฆ  load predicts malignoma post kidney TX ๐Ÿ’ช

๐Ÿ‘ carsten herz at #era25

viruses ๐Ÿฆ  can be ๐Ÿฆธ superheros
TTVbased immune monitoring
#TTVguide

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Sebastian Kapps presents
first data on Torque Teno virus ๐Ÿฆ 
in long-term kidney TX patients
at #ERA25 #TTVguide

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#TTVguide ๐Ÿ’ช

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full engangement on our โ€žyear 4โ€œ TTVguideTX project meeting ๐Ÿ’ช

viruses ๐Ÿฆ  can be superheros ๐Ÿฆธโ€โ™€๏ธ
#TTVguide

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we did it ๐Ÿ‘๐Ÿพ๐ŸŽ‰๐Ÿ•บ๐Ÿ’ƒโ˜บ๏ธ

today was last visit of the last patient of the TTVguideIT study

260 KTX recipients randomiced to torque teno virus ๐Ÿฆ  guided immunosuppression vs SOC and followed for one year

thanks to all 13 recruiting centers across europe

#ttvguide

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#ttvguide

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Sebastian Kapps taking science ๐Ÿงฌ to the public ๐Ÿ‘จ๐Ÿฝโ€๐Ÿฆฑ๐Ÿ‘ฉ๐Ÿพ๐Ÿ‘จ๐Ÿผโ€๐Ÿฆฒ๐Ÿ‘ต๐Ÿผ

can we use a virus ๐Ÿฆ  to quantify the immune system? #ttvguide

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Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood The main challenge of immunosuppressive therapy after solid organ transplantation is creating an immunological balance that prevents organ rejection without promoting opportunistic infections. Torque ...

๐Ÿ“ข Partners from @chugrenoblealpes.bsky.social showed that TTV DNA load was slightly higher in whole blood (WB) than in plasma. Overall TTV detection was similar and distribution of TTV DNA loads did not differ. Read the full paper here: www.kireports.org/article/S246... #TTVguide

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