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Posts tagged #TranslationalScience

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Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

Age-related inhibition of #GutBrainSignaling reduces hippocampal activity and impairs #MemoryEncoding doi.org/10.1038/s415... #Aging #Microbiome #TranslationalScience

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Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer - Nature Biomedical Engineering A pan-haematologic cancer approach, involving analysis of data from 256 patients across 5 cancer types and 13 clinical trials, revealed predictive biomarkers for understanding the response or non-resp...

Leveraging #ComputationalBiology at scale to individualize #Immunotherapy: www.nature.com/articles/s41... @JoeFraietta @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

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CTSC staff member stands behind a UC Davis Clinical and Translational Science Center outreach table with informational materials, pens, and a prize wheel during the UC Davis Principles of Community celebration.

CTSC staff member stands behind a UC Davis Clinical and Translational Science Center outreach table with informational materials, pens, and a prize wheel during the UC Davis Principles of Community celebration.

A walkway outside the Betty Irene Moore School of Nursing lined with international flags representing diverse cultures during the Principles of Community celebration.

A walkway outside the Betty Irene Moore School of Nursing lined with international flags representing diverse cultures during the Principles of Community celebration.

A DJ plays music in the atrium of the Betty Irene Moore School of Nursing while international flags and artwork decorate the space during the event.

A DJ plays music in the atrium of the Betty Irene Moore School of Nursing while international flags and artwork decorate the space during the event.

A small rubber duck wearing sunglasses is held up outdoors on the UC Davis Health campus lawn.

A small rubber duck wearing sunglasses is held up outdoors on the UC Davis Health campus lawn.

🎉Celebrating 36 years of the UC Davis Principles of Community!🎉

On March 3, CTSC staff joined colleagues at the Betty Irene Moore School of Nursing to celebrate the cultures and communities that shape our workplace and the people we serve!

#TranslationalScience #CTSC #Community

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Generative Artificial Intelligence: Implications for Families and Pediatricians Generative artificial intelligence (AI) technologies, capable of producing original text, images, audio, and video, are increasingly embedded in children’s learning, play, and daily life. Pediatric clinicians and parents face the challenge of guiding children toward safe and constructive engagement with these rapidly evolving tools. This state-of-the-art review synthesizes current knowledge regarding opportunities, risks, and best practices related to children’s interactions with generative AI. Developmental considerations are emphasized because the impact of AI varies across early childhood, middle childhood, and adolescence. We highlight potential benefits, including personalized learning, creative expression, and enhanced communication, while also discussing risks such as misinformation, privacy threats, and false perceptions of AI as a friend or caregiver. Evidence-based strategies are proposed to promote AI literacy, critical thinking, and safe integration of AI into pediatric care and education.

Charting a course toward meaningful #AIliteracy in #PediatricCaregiving doi.org/10.1542/peds... #AI #MediaLiteracy #GenerativeArtificialIntelligence #TranslationalScience

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Optimizing #CRISPR for #FunctionalGenomics in patient-derived #Xenograft and primary #AcuteMyeloidLeukemia w/ diverse #PathogenicMutations doi.org/10.1016/j.mo... @junwei_s #AML #TranslationalScience

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Discover the Power of DAVE: A Researcher’s Guide to Databricks
📅 March 20, 2026
⏰ 1–2 p.m.
💻 Zoom

Learn how DAVE and Databricks can accelerate research workflows, simplify data management, and help extract insights from complex data!

🔗 Register: airtable.com/appPzowN8ekL...

#TranslationalScience

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Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

Novel insight into where the #Neanderthal DNA that persists in people today comes from: www.science.org/doi/10.1126/... @sarahtishkoff.bsky.social #PaleoGenomics #EvolutionaryBiology #TranslationalScience

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📢 ILT Class: Stem Cell Oversight in Research
📅 Feb 26, 2026
⏰ Noon–1:30 p.m. PST
🎤 Alaisha Hellman

Learn about protocol approval, SCRO disclosures, RECO review, and the SCRO Committee’s role.

🔗 Advanced LMS registration required:
uc.sumtotal.host/rcore/c/pill...

#TranslationalScience #CTSC

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Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression - Neuroscience Bulletin Neuroscience Bulletin -

Ding et al. identified reduced serum beta-endorphin as a core biological signature of adolescent non-suicidal self-injury. #MentalHealthResearch #TranslationalScience See here: doi.org/10.1007/s122...

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Art as a multiplier of science communication | Journal of Clinical and Translational Science | Cambridge Core Art as a multiplier of science communication - Volume 10 Issue 1

Reimagining scientific communication using art as a tool for the next generation of translational scientists doi.org/10.1017/cts.... @carstenskarke.bsky.social #ITMATEd #ScienceCommunication #SciComm #SciArt #WorkforceDevelopment #TranslationalScience

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The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen-presenting cells shape the T cell repertoire, recent discoverie....

👀 Our latest review is out in Immunological Reviews.

We revisit the search for #stemness in an involuting organ - and the paradox at the heart of #thymus biology 💡

#Thymus #StemCells #Regeneration #Immunology #TranslationalScience #OrganReconstruction @crick.ac.uk @ucl.ac.uk

shorturl.at/u6xJK

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Depression of tryptophan may contribute to adverse effects of naproxen - Nature Communications Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been associated with adverse effects affecting both the cardiovascular and gastrointestinal systems. Here the authors show that NSAIDs lower plasma ...

#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience

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Bile acid analogs targeting C. difficile spore germination safely altered bile acid homeostasis in vivo — supporting prophylactic development.

Research from WSU EACPHS.

#ClostridioidesDifficile #TranslationalScience

doi.org/10.3390/biom...

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Wellbeing International Foundation backs cell-free regenerative therapy aimed at restoring the body’s repair language.

vist.ly/4rw22

#longevity #RegenerativeMedicine #CellFreeTherapy #Biotechnology #HealthyAging #TissueRepair #NextGenMedicine #TranslationalScience

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Advance research in immune-mediated inflammatory diseases and beyond by submitting your work to Signal Transduction and Targeted Therapy.
mts-sigtrans.nature.com
#ImmunologyResearch #TranslationalScience

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DPUK’s focus: building “complex knowledge” — integrating imaging, genomics, biomarkers, trials and AI etc., within shared research architectures. Connecting these disciplines is a force multiplier for #dementia discovery. #DementiaResearch #TranslationalScience
zurl.co/oKkaN

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Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience

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Scientists chart the development of human muscle, opening new avenues for tackling sarcopenia and frailty.

vist.ly/4r825

#longevity #HealthyAging #Sarcopenia #MuscleHealth #FrailtyPrevention #Genomics #AgingResearch #TranslationalScience

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Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jb... #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience

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JCI Insight - BRD4 promotes endodermal cell fate during mammalian lung development

#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience

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Join this session of Digital Health, AI, and Implementation at UC Davis: Research and Real-World Practice to learn how AI scribe technology is being introduced and applied across UC Davis!

#TranslationalScience #CTSC #DataScience

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Translational Science Grand Rounds: Digital Twins vs. Virtual Patients

Digital Twins vs. Virtual Patients on Mar. 12

Juilee Thakar, PhD, will present how mechanistic mathematical models developed using large-scale omics data can be used to develop digital twins and virtual patients.

events.rochester.edu/event/digita...

#URochesterResearch #TranslationalScience

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#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience

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📚 ILT Class: Understanding and Evaluating Stipend and Reimbursement Practices for Trial Participants

🗓 Feb 11, 2026
⏰ 12–1:30 PM PST

Advanced registration required (LMS):
nam13.safelinks.protection.outlook.com?url=https%3A...

#ClinicalResearch #TranslationalScience #CTSC

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📚 ILT Class: Clinical Protocols—How to Avoid Site Noncompliance and Shine

🗓Feb 5, 2026
⏰10–11:30 AM PST

Practical strategies to improve protocol use & site compliance.

Register (LMS): uc.sumtotal.host/Broker/publi...

#CTSC #ClinicalResearch #TranslationalScience

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JCI - Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use

#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience

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Mentoring Workshops | UC Davis CTSC Workshops for the Mentoring Academy for Research Excellence

📣 Registration open for the MARE Spring Workshop Series!
Virtual workshops for mentors & mentees, aligned with NIH NIGMS & T32 guidelines.

🗓 March 3–18
💻 Zoom
👉 Details & register: health.ucdavis.edu/ctsc/area/ed...

#TranslationalScience #CTSC #MARE

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KOHORT K Award Program | Office of Research | UC Davis School of Medicine KOHORT is a five-month program solely for postdocs and early-stage investigators.

🗣️ Now accepting applications: KOHORT K Award Program 2026 (UC Davis School of Medicine)

📅 Apply by: Feb 6, 2026
📣 Notifications: Mar 2, 2026
✅ Program begins: Mar 19, 2026

🔗 Learn more & apply:
health.ucdavis.edu/medical-scho...

#TranslationalScience #CTSC #Kaward #KOHORT

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The Tobacco Cessation Policy Research Center (TCPRC) is accepting applications for its Pilot Research Award – Cycle 3!

🚨 Deadline: Jan 30, 2026 (5 PM PST)

Open to UC Davis junior & early-career investigators

Questions: sptu@health.ucdavis.edu

#TranslationalScience #CTSC

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MCRTP Call for Applications | UC Davis Clinical and Translational Science Center 📣Now Open: Mentored Clinical Research Training Program (MCRTP) Call for Applications! The UC Davis Clinical and Translational Science Center (CTSC) is now accepting applications for the next cohort o...

Mentored Clinical Research Training Program (MCRTP) Call for Applications!

🚨Application Deadline Extended: March 2, 2026 at 10 a.m. PST🚨

For more information, please visit: www.linkedin.com/posts/ucdavi...

#TranslationalScience #CTSC #MCRTP

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