🚨🙀T minus 20 minutes until the IDCOP Town Hall. See you there??! (Check the Hub for zoom link) #TxID
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Posts tagged #TxID
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Emerging risk factors for IFI in HCT. Climate change, older/comorbid recipients, antifungal prophylaxis, changes in GVHD prophylaxis and treatment, longer survivorship, agricultural use of antifungals
Invasive Fungal Disease in Allogeneic Hematopoietic Cell Transplantation: New Risk Factors and New Therapeutic Options in a Changing World
@abbydouglas.bsky.social & Monica Slavin
doi.org/10.1111/tid.... #TxID #IDSky #MedMycoSky
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O bug do TXID e como resolvemos na Original My
Já ficou esperando uma transação que simplesmente nunca aparecia na blockchain? 😓
- 🔍 O problema: a gente monitorava apenas o TXID e, muitas vezes, alguém na rede alterava a transação — outro TX era minerado e […]
[Original post on mastodon.social]
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Graphical abstract showing summaries of the demographic data (M 71%, HIV 57%, SOT 18%, autoimmune disease 16%), sites of infection (CNS 91%, fungemia 60%, lung 40%), ICU management (mech ventilation 55%, pressers 34%, RRT 18%), and outcome (ICU mortality 42%, 90d mortality 50%)
Presentation and prognosis of cryptococcosis requiring intensive care unit admission in France: the CRYPTO-ICU study
Retrospective study of 151 patients admitted to 30 French ICUs with cryptococcosis over 23 years
academic.oup.com/cid/advance-... #IDSky #TxID #CritCare #MedMycoSky
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Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin α3β1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1α (HIF1α) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-βD-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyte–macrophage colony-stimulating factor (GM-CSF) and IFN-γ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue …
Risk factors for Mucormycosis
Risk factors for mucormycosis continued
Mucormycosis
Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh
www.nejm.org/doi/10.1056/...
#IDSky #TxID #MedMycoSky @msgerc.bsky.social
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Table of recommendations part 1
Table of recommendations part 2
Fungal diagnostic stewardship in immunocompromised populations: a focus on molds and dimorphic fungi
@jmsteinbrink.bsky.social @hannah-imlay.bsky.social et al on behalf of @msgerc.bsky.social
journals.asm.org/doi/10.1128/... #IDSky #MedMycoSky #MicroSky #TxID
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Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses
Tom Harrison & Tom Walsh
www.thelancet.com/journals/lan... (paywall) #IDSky #TxID
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#TxID #Mycology
Challenging case of disseminated Scedo in a BOLT pt who has been on olorofim/posa x 3.5 years. MICs for posa now >16. Fungal ball in renal collecting system. Worsening renal fxn on AMB-D irrigations. HELP!
@fungaldoc.bsky.social @germhuntermd.bsky.social @michaelisonmd.bsky.social
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with @agstewart.bsky.social Hyun Yoon, Julie Steinbrink, Daniel Friedman, @drluiso.bsky.social
#OpenAccess #TxID #IDSky #SciSky
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1/ 🚨Recent #PhD publication🚨
Knowledge and Attitudes about Solid Organ #Transplantation for People with HIV in Australia: A Cross-sectional Survey of People with and without #HIV
#SOT #TxID #IDSky #TxIDSky
#healthequity
journals.lww.com/jaids/abstra...
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Our new article on Fidaxomicin for 1st CDI episode in ICHs is now available on @OFIDJournal
11,204 pts with 1st CDI episode
2,362 ICHs
The Fidaxomicin group had lower CDI recurrence compared to vancomycin (aOR 0.44, 95%CI 0.21–0.96)
#TxID
academic.oup.com/ofid/article/d…
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🔍 Pleased to report our sub-cohort analysis of the INTERACT study evaluating IPC and surveillance practice in Australasian solid-organ transplant recipients has just been published in Transplant-ID!
doi.org/10.1111/tid....
#TxID @ncicancer.bsky.social @thetxidjournal.bsky.social
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Year in review, California Department of public health. With the erosion of trust in the ACIP and other federal agencies, state public health departments have an important role in providing guidance on vaccination. Do others in #TxID have a state resource you can rely on? @ast-idcop.bsky.social
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Human-to-Human Rabies Transmission via Solid Organ Transplantation from a Donor with Undiagnosed Rabies — United States, October 2024–February 2025
MMWR
A man died of donor-derived rabies after receiving a kidney transplant from a donor scratched by a skunk.
www.cdc.gov/mmwr/volumes... #TxID
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Great event at the XIX Course on Infections in Immunocompromised Patients – HCFMUSP!
I had the opportunity to give an update on CMV in the context of HSCT #HSCT #BMT #IDSky #TxID
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Congrats to all of those who participated in the NRMP match this year - and welcome to the amazing field of ID!
Don’t forget that the IDCOP Town Hall is Friday 12/5 at 2pm. Zoom info on the Hub and in your email. #TxID
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Come train with us!
We have two open spots for ID fellowship at @ou.edu
Great clinical exposure, academic tracks (TxID, healthcare admin/hospital epi, trop med/global health, CCM fellowship), 12-credit certificates covered by the program.
#IDSky #TxID #MedEd
medicine.ouhsc.edu/academic-dep...
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CMV-specific cell-mediated immunity for prediction of post-prophylaxis CMV disease in a phase 3 trial of letermovir vs valganciclovir prophylaxis in D+/R- kidney transplant recipients
TLDR: CMV CMI assay at end of ppx did NOT predict subsequent CMV disease
academic.oup.com/cid/advance-... #TxID
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Dr. Blumberg reminding Americans that the Transplant Community is fully supportive of the safety and efficacy of vaccines.
Efforts 2 weaken recommendations & 2 question vaccine safety lead to 📉 uptake. Community immunity is crucial to protecting these vulnerable pts. #TxID
tinyurl.com/3evskx3w
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Set your calendars for the AST IDCOP Town Hall on 12/5/25 @2pm ET! Connect with the Exec Committee, get updates on the Donation Derby, learn about new guidelines, and more! Details for registration in your email / The Hub. #TxID #IDSky
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What are #TxID #IDSky folks doing with invasive Fusarium infections 🌱 in stem cell patients- do you routinely send susceptibility testing ? 🤔@drfungus.bsky.social @fungaldoc.bsky.social @ast-ldcop.bsky.social @idsainfo.bsky.social @escmid.bsky.social ? Let me know your thoughts!!
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Hepatitis B vaccination is so important for #TxID - it would be a real loss for public health as a whole as well as future transplant candidates to lose out on this opportunity for universal vaccination - please comment on this ACIP proposal! @ast-idcop.bsky.social
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Done! #TxID @astinfo.bsky.social
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Algorithm for the management of suspected IC with septic shock. *For patients with IC who do not present with septic shock, empiric antifungal therapy should be withheld. In these cases, investigations should focus on obtaining blood cultures and, where relevant, site-directed samples. Biomarkers such as serum BDG may support discontinuation when suspicion decreases but should not be used as a trigger to initiate antifungal therapy. BDG (1 → 3)-β-D-glucan; IC Invasive candidiasis; R Resistance
Table 5: Key actions in management of persistent candidemia
Table 6 Combination strategies for difficult deep-seated refractory infections. Combination therapy is not routine. Reserve it for the specific scenarios above (endocarditis, CNS involvement, ocular disease, renal candidiasis with obstruction, persistent candidemia or very high fungal burden despite source control, suspected/proven resistance, major PK uncertainty or delayed TDM), begin with a pre-defined 48–72 h reassessment, obtain early susceptibility testing, perform TDM for azoles and consider it for echinocandins in complex PK settings, and de-escalate to the narrowest effective monotherapy as soon as feasible. In summary, avoid routine concurrent Amphotericin B–azole combinations for Candida spp. unless there is a compelling salvage reason; prefer alternative pairs (e.g., echinocandin + azole) if combination therapy is needed. If stepping from an azole to Amphotericin B, be aware of potential carry-over effects; if stepping from Amphotericin B to an azole, keep the overlap brief
Invasive candidiasis in intensive care medicine: shaping the future of diagnosis and therapy
Martin-Loeches et al, Intensive Care Medicine
link.springer.com/article/10.1... #IDSky #TxID #MedMycoSky
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New study shows antagonism between olorofim and voriconazole in vitro, suggesting this may be a class effect
academic.oup.com/jac/advance-... #MedMycoSky #TxID #IDSky
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