#UKBB

Kanton BL

@kantonbl.bsky.social

3 months ago

#Regierungsbulletin mit #SwisslosFonds #UniversitätBasel #Primarschule #Zwingen #UKBB #BVB #LohntabelleBL #TarifePflegeleistungen

zur Medienmitteilung: https://bit.ly/3KOaS4A

EVP Baselland

@evp-bl.bsky.social

4 months ago

#LandratBL stimmt mit 57:21:8 Finanzierung gemeinwirtschaftlicher Leistungen & ungedeckter Kosten des #UKBB für die Jahre 2026/29 zu.
Allerdings mit Erwartungshaltungen.
#RegulaStreun 👉gesamte Debatte #LandratBL: baselland.talus.ch/de/dokumente...

Kanton BL

@kantonbl.bsky.social

4 months ago

#LandratBL beschliesst mit 57:21 Stimmen bei 8 Enthaltungen eine neue einmalige Ausgabe in Höhe von CHF 42,44 Mio. für die Finanzierung der gemeinwirtschaftlichen und besonderen Leistungen des Universitäts-Kinderspitals beider Basel für die Jahre 2026–29 – #UKBB zum Traktandum https://bit.ly/4oc5zdH

Kanton BL

@kantonbl.bsky.social

4 months ago

Landratssitzung

Vorschau auf die Landratssitzung vom 30. Oktober 2025 #LandratBL
#Einbuergerungsgesuche #UKBB #MischwasserbeckenRuetschacher

Mehr dazu: https://bit.ly/49hCPLR

@ddofer.bsky.social

9 months ago

3/ On 8 major diseases and 400 K patients, we select ~40 features per disease out of >3700. ~⅓ of those got validated by medical researchers! SHAP‑ranked lists managed ~0-7 %.
#UKBB #UKBiobank #medicine #SHAP

Katherine Thomasset

@kaththomasset.bsky.social

11 months ago

Variants in the MTNR1B gene linked to higher HbA1c In this study of #UKBiobank data #DiabetesResearch #Endocrinology #Genetics #UKBB #MedSky

Diabetologia

@diabetologiajnl.bsky.social

11 months ago

Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes - Diabetologia Aims/hypothesis An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence. However, MTNR1B missense variants have shown conflicting results on type 2 diabetes. Thus, we aimed to gain further insights into the impact of MTNR1B coding variants on type 2 diabetes prevalence and related phenotypes. Methods We conducted a cross-sectional study, performing MTNR1B variant burden testing of glycaemic phenotypes (N=248,454, without diabetes), other cardiometabolic phenotypes (N=330,453) and type 2 diabetes prevalence (case–control study; N=263,739) in the UK Biobank. Similar burden testing with glycaemic phenotypes was performed in Danish Inter99 participants without diabetes (N=5711), and type 2 diabetes prevalence (DD2 cohort serving as cases [N=2930] and Inter99 serving as controls [N=4243]). Finally, we evaluated the effects of MTNR1B variants on the melatonin-induced glucose regulation response in a recall-by-genotype study of individuals without diabetes. Results In the UK Biobank, MTNR1B variants were not associated with cardiometabolic phenotypes, including type 2 diabetes prevalence, except that carriers of missense MTNR1B variants causing impaired MT2 signalling exhibited higher HbA1c levels compared with non-carriers (effect size, β, 0.087 SD [95% CI 0.039, 0.135]). Similarly, no significant associations were observed with phenotypes associated with glycaemic phenotypes in the Inter99 population. However, carriers of variants impairing MT2 signalling demonstrated a nominally significant lower glucose-stimulated insulin response (β −0.47 SD [95% CI −0.82, −0.11]). A reduced insulin response was also observed in carriers of variants impairing MT2 signalling (β −476.0 [95% CI −928.6, −24.4]) or the rs10830963 variant (β −390.8 [95% CI −740.1, −41.6]) compared with non-carriers after melatonin treatment. Conclusions/interpretation The higher type 2 diabetes prevalence previously observed in carriers of missense MTNR1B variants causing impairment in MT2 signalling was not replicated in the UK Biobank, yet carriers had elevated HbA1c levels. Data availability Data (Inter99 cohort and recall-by-genotype study) are available on reasonable request from the corresponding author. Requests for DD2 data are through the application form at https://dd2.dk/forskning/ansoeg-om-data . Access to UK Biobank data can be requested through the UK Biobank website ( https://www.ukbiobank.ac.uk/enable-your-research ). Graphical Abstract

Combined burden of rare variants in MTNR1B impairing MT2 signalling associates with elevated HbA1c levels in the UK Biobank but does not associate with type 2 diabetes #MTNR1B #MT2 #HbA1c #genetics #UKBB link.springer.com/article/10.1... 🔓

Kuldeep Kumar

@kkumar.bsky.social

1 year ago

"Gene dosage architecture across complex traits".

Excited to share our work led by the excellent @KazemSayeh (joint co-author).

We will post a detailed 🧵 in the coming days. Please reach out if you have any questions.

www.medrxiv.org/content/10.1...

#CNVs #GeneDosage #UKBB

Anastasia Baryshnikova

@abarysh.bsky.social

1 year ago

Platform-dependent effects of genetic variants on plasma APOL1 and their implications for kidney disease Mutations in apolipoprotein L1 (APOL1) are strongly associated with an increased risk of kidney disease in individuals of African ancestry, yet the underlying mechanisms remain largely unknown. Plasma...

New preprint! Our latest work on plasma proteomics in UKBB helps unraveling the fascinating connection between APOL1, parasite resistance, and kidney disease.

www.biorxiv.org/content/10.1...

#APOL1 #KidneyDisease #Plasma #Proteomics #Genetics #Biomarkers #KallikreinKinin #AfricanAncestry #UKBB

@nate-carter.bsky.social

1 year ago

This #UKFB season has been brutal but Pope has softened the blow and I can’t wait to shift my full sports focus to #UKBB. We’re in for a special season on the hardwood. #BBN

DPrime - The Oil City Saint

@dprime.bsky.social

13 years ago

I prefer #ukBB when they announce “you’re live on channel ___, please don’t swear!” #bb14