Left: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies for 276 disorders according to ICD-10 codes and adjusted for age and sex. Triangles pointing upwards and downwards: positive and negative coefficients, respectively; gray dashed line: P < 0.05 after Bonferroni correction (here and henceforth). P values significant after Bonferroni adjustment are labeled with the ICD codes. Right: −log10(P value) of the log-binomial regression for the presence of plasma MTBD-tau IgG autoantibodies and clinical laboratory parameters P values significant after Bonferroni adjustment are labeled with the clinical laboratory parameters. eGFR CKD-EPI 2009: estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration 2009 equation; eGFR BIS1: estimated glomerular filtration rate using the older adults Berlin Initiative Study 1 equation. INR: international normalized ratio. LDL: low-density lipoprotein. HDL: high-density lipoprotein.
What is the role of anti-tau autoantibodies in disease? A screen of 40,497 human plasma samples reveals that anti- #tau #autoantibodies are highly prevalent, increase with age, and are associated with #kidney & #urinary disorders but not #neurological disease @plosbiology.org 🧪 plos.io/43XXwsZ