New in @jem.org from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...
#Immunology #Mitochondria #Ak4
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