Inhibitory neurons differentially control sound-evoked responses in the MGB. Left: diagram of the proposed circuit underlying our results. Boxes: summary of effects of optogenetic manipulation of SSTTRN (top) or PVTRN (bottom) inactivation on MGB firing and the circuitry and results of computational models that support a similar distribution of effects.
The medial geniculate body #MGB in the #auditory #thalamus is a key early node in sound processing. @geffenlab.bsky.social &co show in mice that two inhibitory neuron types have distinct connectivity & effects on sound processing. @plosbiology.org 🧪 plos.io/47twOtM