#flavin

SCHEMA Hub

@schemahub.bsky.social

3 months ago

Article: H2-Driven Flavin Recycling Supports Biocatalytic Halogenation by Flavin-Dependent Halogenase Authors: Jiayu Peng, Miguel A. Ramirez, Kylie A. Vincent

📣 New Publication 🧪

📄 H2-Driven Flavin Recycling Supports Biocatalytic Halogenation by Flavin-Dependent Halogenase

🔗 Read it here: doi.org/10.1002/cctc...
📲 View SCHEMA research: schemahub.web.ox.ac.uk/publications

#Biocatalysis #Flavin #Halogenation #Chemistry

@chemistryeurope.bsky.social

NevereverDave.bsky.social

@nevereverdave.bsky.social

4 months ago

Cats, Tomboys, & etc! All proves #Flavin has been reading poisonous anti trans & gender diverse garbage we saw years ago in the #UK - it's still garbage and she should seek out professional help from someone with their feet firmly planted on the ground. Stop being the problem for struggling parents.

fabio omero

@fabioomero.bsky.social

8 months ago

fabio omero - F FABRO

#FABRO
#FISCHER
#FISCHLI&WEISS
#FLAVIN
#FONTANA
#FRIEDRICH
#FÜSSLI

sites.google.com/view/fabioom...
#FAKEART #FUCKART
#POPulism #DADA #DADAISM #SURREALISM #NEWDADA #POPART #CONCEPTUALART #CONCEPTUALPHOTO #APPROPRIATIONART #IMITATIONART #D'APRES #CITATIONISM #CONTEMPORARYART #ESTHÉTIQUERELATIONNELLE

Marc Kielmann Bolten

@henloeditorfren.bsky.social

11 months ago

Amazing presentation by Golo Storch on #flavin catalysis at the #Chemiedozententagung #CDT2025.

Mark Sanders

@msanders.mas.to.ap.brid.gy

1 year ago

Houston! Flavin! #modernart #flavin #menil

Dirk Tischler

@dirktischler.bsky.social

1 year ago

Kinetic and structural investigation of the 4-allyl syringol oxidase from Streptomyces cavernae 4-Phenol oxidases are proposed to be involved in the utilization of lignin-derived aromatic compounds. While enzymes with selectivity towards 4-hydrox…

The last research article of @danieleggerichs.bsky.social PhD thesis was just published, supported by wonderful collaboration with the @mattevilab.bsky.social it's part of a special collection for #flavins and #flavoproteins, and we report on a #flavin #oxidase
www.sciencedirect.com/science/arti...

Dirk Tischler

@dirktischler.bsky.social

1 year ago

Dehydrogenase versus Oxidase Function: The Interplay between Substrate Binding and Flavin Microenvironment Redox enzymes, mostly equipped with metal or organic cofactors, can vary their reactivity with oxygen by orders of magnitude. Understanding how oxygen reactivity is controlled by the protein milieu remains an open issue, with broad implications for mechanistic enzymology and enzyme design. Here, we address this problem by focusing on a widespread group of flavoenzymes that oxidize phenolic compounds derived from microbial lignin degradation, using either oxygen or cytochrome c as an electron acceptor. A comprehensive phylogenetic analysis revealed conserved amino acid motifs in the flavin-binding site. Using a combination of kinetic, mutagenesis, structural, and computational methods, we examined the role of these residues. Our results demonstrate that subtle and localized changes in the flavin environment can drastically impact oxygen reactivity. These effects are afforded through the creation or blockade of pathways for oxygen diffusion. Substrate binding plays a crucial role by potentially obstructing oxygen access to the flavin, thus influencing the enzyme’s reactivity. The switch between oxidase and dehydrogenase functionalities is thereby achieved through targeted, site-specific amino acid replacements that finely tune the microenvironment around the flavin. Our findings explain how very similar enzymes can exhibit distinct functional properties, operating as oxidases or dehydrogenases. They further provide valuable insights for the rational design and engineering of enzymes with tailored functions.

Great study on the question what defines an #oxidase vs. a #dehydrogenase... and vice versa #proteinengineering #biocatalysis #flavoprotein #flavin #enzymology

pubs.acs.org/doi/10.1021/...

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@lustbarkeit.bsky.social

1 year ago

It's called style. #Flavin

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@lustbarkeit.bsky.social

1 year ago

More #Flavin. Kunstmuseum Basel.

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@lustbarkeit.bsky.social

1 year ago

Meet #Flavin. Kunstmuseum Basel.

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@lustbarkeit.bsky.social

1 year ago

Licht zur Kontemplation. #Flavin

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@lustbarkeit.bsky.social

1 year ago

Shades of #Flavin.

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@lustbarkeit.bsky.social

1 year ago

"untitled (to my dear bitch, Airily) 2, 1984" by #Flavin. Visit Kunstmuseum Basel to see more.

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@lustbarkeit.bsky.social

2 years ago

Even more #Flavin. Colors are love.

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@lustbarkeit.bsky.social

2 years ago

#Flavin & enlightenment.

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@lustbarkeit.bsky.social

2 years ago

Dan #Flavin in the house! Visit Kunstmuseum Basel now for the new exhibition.