#hyperpolarization

@soumya-goblue.medsky.social

4 months ago

The first #congress member I'm interviewing with is in the top 10% most #bipartisan members of Congress...in this era of #hyperpolarization that's a great sign of getting sh** done. (I'll give you a wild guess who's dead ass last in #bipartisanship... hint: from #Ohio 😂)

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Angeliki Giannouli

@angelikig.bsky.social

6 months ago

Cryogenic and Dissolution DNP NMR on γ-Irradiated Organic Molecules Nuclear magnetic resonance (NMR) plays a central role in the elucidation of chemical structures but is often limited by low sensitivity. Dissolution dynamic nuclear polarization (dDNP) emerges as a transformative methodology for both solution-state NMR and metabolic NMR imaging, which could overcome this limitation. Typically, dDNP relies on combining a stable radical with the analyte within a uniform glass under cryogenic conditions. The electron polarization is then transferred through microwave irradiation to the nuclei. The present study explores the use of radicals introduced via γ-irradiation, as bearers of the electron spins that will enhance 1H or 13C nuclides. 1H solid-state NMR spectra of γ-irradiated powders at 1–5 K revealed, upon microwave irradiation, signal enhancements that, in general, were higher than those achieved through conventional glass-based DNP. Transfer of these samples to a solution-state NMR spectrometer via a rapid dissolution driven by a superheated water provided significant enhancements of solution-state 1H NMR signals. Enhancements of 13C signals in the γ-irradiated solids were more modest, as a combined consequence of a low radical concentration and of the dilute concentration of 13C in the natural abundant samples examined. Nevertheless, ca. 700–800-fold enhancements in 13C solution NMR spectra of certain sites recorded at 11.7 T could still be achieved. A total disappearance of the radicals upon performing a dDNP-like aqueous dissolution and a high stability of the samples were found. Overall, the study showcases the advantages and limitations of γ-irradiated radicals as candidates for advancing spectroscopic dDNP-enhanced NMR.

One more DNP paper in JACS:
Cryogenic and Dissolution DNP NMR on γ-Irradiated Organic Molecules. We introduced γ-irradiation–generated radicals to enhance ¹H and ¹³C signals via DNP under cryogenic and dissolution conditions.
🔗 pubs.acs.org/doi/full/10....

#NMR #DNP #Hyperpolarization

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Angeliki Giannouli

@angelikig.bsky.social

6 months ago

Toward Generalized Solution-State 1H DNP NMR via Particle-Mediated Cross-Relaxation This study discusses a potential route for enhancing 1H NMR signals in the liquid phase at high magnetic fields for samples on the 100 μL volume scale using dynamic nuclear polarization (DNP). The approach involves dispersing an inert powder that is both rich in protons and capable of undergoing DNP with good efficiency at noncryogenic temperatures, and letting the solid 1H polarization thus enhanced pass from the dispersed particles onto the surrounding liquid via spontaneous cross relaxation effects. To this end, BDPA-doped polystyrene (PS) particles in the μm range were suspended in 30 μL of heptane, loaded into 3.2 mm sapphire rotors, and spun at ≈500 Hz for homogeneity purposes in a 14.1 T magnet. Irradiation with ≈13 W at 395 GHz while maintaining temperature in the 185–220 K range thus enhanced the PS proton polarization ≈12-fold within ≈2 s; after ca. 6 s of irradiation, this resulted in ca. 3-fold enhancements of the heptane proton resonances, while preserving their ≤2 Hz line widths. The conditions over which such particle-mediated transfer occurs were explored over a range of sample composition, deuteration and molecular weight; best results were obtained when polarizing a ball-milled powder made of deuterated-PS/PS/BDPA = 86.4/9.6/4.0 suspended on perdeuterated heptane-d16. While the solution-state enhancements provided by this approach are still relatively modest, its generality could open new avenues in DNP-enhanced 1H NMR that do not sacrifice on the volumes, on the high-resolution conditions, or on the multiscan averaging that is customary in contemporary applications.

New paper out in J. Phys. Chem. Lett.: Toward Generalized Solution-State ¹H DNP NMR.
BDPA-polystyrene boosts ¹H ~12× in 2s, transfers ~3× to liquids in 6s
🔗 pubs.acs.org/doi/full/10....
#NMR #DNP #Hyperpolarization

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Ulm's Institute of Theoretical Physics

@qubitulm.bsky.social

7 months ago

Martin presenting the groups work on quantum control for quantum sensing and nuclear spin hyperpolarisation at the QI2025 in Osaka. The colourful pictures in the background show the performance of our PulsePol sequence in parahydrogen induced polaridsation. #quantum #NMR #hyperpolarization

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Kerti Ausmees

@kertiausmees.bsky.social

7 months ago

Reile | INNOCHEMBIO | TalTech Affordable but High-Sensitivity NMR SpectroscopyNMR spectroscopy is one of the most versatile analytical methods in the chemical laboratory. Its ability to

📣Deadline 31.08.2025! If you are looking for an interesting fully funded #PhD program in #NMR, then we have a position available in our group funded by #MSCA #COFUND Doctoral Programme. Shared time between #KIT Find out more here: taltech.ee/en/innochemb... #Hyperpolarization #NMRchat #NMRjobs

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Kerti Ausmees

@kertiausmees.bsky.social

7 months ago

Pleased to share our new paper! We tackle resolution & sensitivity limits in affordable benchtop #NMR using nhPHIP hyperpolarization to resolve a dilute mixture of 8 amino acids—expanding practical benchtop NMR use.
#hyperpolarization #nhPHIP #BenchtopNMR #ChemComm #NMRChat
doi.org/10.1039/D5CC...

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Kerti Ausmees

@kertiausmees.bsky.social

7 months ago

I'm pleased to share that our paper "Detection of Adenosine Phosphates in Blood by nh-PHIP" has been published in ACS Analytical Chemistry. #NMR #Hyperpolarization #ATP #metabolomics #nhPHIP

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Kerti Ausmees

@kertiausmees.bsky.social

8 months ago

Reile | INNOCHEMBIO | TalTech Affordable but High-Sensitivity NMR SpectroscopyNMR spectroscopy is one of the most versatile analytical methods in the chemical laboratory. Its ability to

📣If you are looking for an interesting #PhD program then we have a position available in our group funded by #MSCA #COFUND Doctoral Programme. Find out more here: taltech.ee/en/innochemb... #NMR #Hyperpolarization #NMRchat #NMRjobs

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Danila Barskiy

@spinbarsky.bsky.social

1 year ago

Affordable robotic arm system for benchtop hyperpolarization-enhanced NMR experiments Optimization of nuclear spin hyperpolarization experiments often require varying one system parameter at a time (or several parameters in a nontrivial manner) as well as multiple repetitions of signal...

Check our new preprint: Affordable robotic arm system for benchtop hyperpolarization-enhanced NMR experiments 🦾🧪🧲 doi.org/10.26434/che... #NMR #hyperpolarization #automation #chemistry

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Ruud

@70ra.bsky.social

1 year ago

Last night, I read through the proof one last time before publication. Coming soon: "Improved 2D hydride detection for NMR-chemosensing via p‐H2 Hyperpolarization"
#Hyperpolarization #homodecoupling #parahydrogen #aminoacids

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