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Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance Kindel et al. show that repeated exercise potentiates the activity of ventromedial hypothalamic SF1-expressing neurons. SF1 neural activity is required for mice to achieve the endurance benefits of ex...

#Exercise -induced activation of ventromedial #hypothalamic steroidogenic factor-1 #neurons mediates improvements in #endurance: Neuron www.cell.com/neuron/fullt...

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Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets www.thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

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IOB
Why not both? A case study in measuring #cortisol and #corticosterone
by S. E. Westrick et al
doi.org/10.1093/iob/...

"A general tenet in stress physiology is that the #hypothalamic- #pituitary-adrenal axis predominantly produces one #glucocorticoid (GC) in response to stressors..."

#frogs

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Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

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Despite the diverse nature of #obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of #brain circuits to this condition www.thelancet.com/journals/lan...
#hypothalamic #obesity

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets www.thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets www.thelancet.com/journals/lan...

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

In addition to being a challenging medical condition, dissection of the basis of #hypothalamic #obesity could help to further elucidate the physiological basis of bodyweight homoeostasis and energy balance www.thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

We provide a synoptic overview of #hypothalamic #obesity, from basic mechanisms to clinical perspectives, with a major focus on current developments and new avenues for the diagnosis & precise treatment of these rare forms of obesity www.thelancet.com/journals/lan... #hyperphagia

#MedSky #EndoSky

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Alexander Wilson-Slomkowski is a #PhD student in the Metabolic Resilience Group at #SHIMR_NTU. At #STAR2025, he presented his research, which utilises a pre-clinical model of divergent #metabolic rate to uncover #hypothalamic targets for #MetabolicHealth. With Nik Morton @rebeccadumbell.bsky.social

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Despite the diverse nature of #obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of #brain circuits to this condition www.thelancet.com/journals/lan...
#hypothalamic #obesity #hyperphagia

#MedSky #EndoSky

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

Despite the diverse nature of #obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of #brain circuits to this condition www.thelancet.com/journals/lan...
#hypothalamic obesity #hyperphagia
#MedSky #EndoSky #NeuroSky

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Although it is classically regarded as an intractable condition, promising perspectives for the surgical and, more recently, pharmacological treatment of #hypothalamic #obesity have emerged www.thelancet.com/journals/lan...
#hyperphagia
#MedSky #EndoSky

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#Hypothalamic #obesity: from basic mechanisms to clinical perspectives thelancet.com/journals/lan...
#hyperphagia
#WorldObesityDay

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The Intricate Relationship Between Circadian Rhythms and Gastrointestinal Peptides in Obesity There are different molecular pathways that regulate appetite, particularly the role of the hypothalamus, circadian rhythms, and gastrointestinal pept…

#Obesity may be linked to #circadian rhythms and gastrointestinal peptide dysregulation.
#GLP-1 and PYY dysregulation may impact #hypothalamic appetite control in obesity.
• CLOCK/BMAL1, REV-ERBα and RORα proteins modulate GLP-1/PYY, offering new obesity treatment avenues.

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Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

In addition to being a challenging medical condition, dissection of the basis of #hypothalamic #obesity could help to further elucidate the physiological basis of bodyweight homoeostasis and energy balance thelancet.com/journals/lan...
#hyperphagia

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Ingrid Camila Possa-Paranhos et al. observed that medial #hypothalamic MC3R signalling regulates energy #rheostasis in adult mice ⚖️ 🔍

📜 Read the #Research here: https://buff.ly/42psqKx

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Kicked off the first day at #WCBR with an amazing plenary from Suzanne Dickson on #ghrelin, #hunger signaling and its effect on #hypothalamic and #midbrain circuits 🧠

Amazing science in an amazing venue! 🤩

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#Sleep and #circadian rhythms modeling: From #hypothalamic regulatory networks to cortical dynamics and behavior
www.sciencedirect.com/science/arti...

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Figure showing the anatomy of the adult and developing tuberal hypothalamus

Figure showing the anatomy of the adult and developing tuberal hypothalamus

From our latest issue: Marysia Placzek, Kavitha Chinnaiya, Dong Won Kim & Seth Blackshaw on the control of tuberal #hypothalamic development and its implications in #metabolic disorders (£) go.nature.com/4gXJyLX

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The #immune- inflammatory responses on #hypothalamic -pituitary- #adrenal axis and the neurovascular unit in perioperative neurocognitive disorder
www.sciencedirect.com/science/arti...

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The microbial metabolite #butyrate can promote #sleep by modulating #orexin neuronal activity in the lateral #hypothalamic area in mice.
www.nature.com/articles/s41...

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Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets
www.thelancet.com/journals/lan...

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#Seasonal food intake and #energy balance

#Seasonal expression of #hypothalamic neurotransmitters in the arcuate nucleus in four different animal models is variable whereas hypothalamic #thyroid hormone control is maintained.
www.sciencedirect.com/science/arti...

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Hypothalamic stem cells control ageing speed partly throu... Ablation of hypothalamic stem/progenitor cells in mice le...

#Hypothalamic stem cells control #ageing speed partly through exosomal #miRNAs http://dx.doi.org/10.1038/nature23282

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