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Posts tagged #immunology

#Science #Nature #Pets #Dog #Vaccine #Health #Medicine #MRNA #chatGTP #AlphaFold #DNA #RNA #Immunology #DesignerDrug #TargettedMedicine #Australia #SmallPharma ( #Cancer #Cure? #Treatment ) #Vet #AI #Innovation #Pioneer #genomics #tumour #mutation #disease #Rosie

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Why cite the Soviet Union and South Africa in this context while ignoring vaccine denialism in the USA? Is that an intellectual blind spot or self-censorship?

#science
#immunology

doi.org/10.1038/s415...

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As a medical school professor, I teach that inflammation from excess visceral fat drives insulin resistan... www.medschool.pitt.edu/news/pitt-research-revea...

#InsulinResistance #Diabetes #MetabolicHealth #Immunology #Longevity

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Types of ELISA Quick Lab Guide from BioResire!
Direct, Indirect, Sandwich, Competitive—master antigen/antibody detection methods.

#ELISA #TypesOfELISA #SandwichELISA #IndirectELISA #DirectELISA #CompetitiveELISA #Immunology #Biotechnology #Biochemistry #LabTechniques #BioResire #Diagnostics

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B cell imprinting in children impairs antibodies to the haemagglutinin stalk - Nature Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

'After consecutive primary heterosubtypic infections, 4–6% of memory B cells in children are cross-group reactive. These imprinted B cells target the central stalk epitope of HA and exhibit major functional differences.'
#Immunology
www.nature.com/articles/s41...

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Current state of CAR-T cell therapies for solid tumors Chimeric antigen receptor (CAR)-T cell therapy is effective in blood cancers but faces obstacles in solid tumors, including antigen heterogeneity and an immunosuppressive tumor microenvironment. This ...

'This review explores the current state of CAR-T cell therapy for solid tumors, highlighting challenges including the pronounced heterogeneity of tumor antigens and the immunosuppressive tumor microenvironment.'
#Immunology #Immunotherapy

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Measles Cases and Outbreaks Find the latest numbers of confirmed U.S. measles cases. CDC updates this page weekly.

CDC's weekly US measles update: 1353 confirmed domestic cases (+9 brought in) in 30 states and NYC.

This is likely an undercount as it is only agency-confirmed cases.

#IDsky #pediatrics #MMR #publichealth #epidemiology #virology #immunology #primarycare

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2026-2027 Flu Vaccine Recommendation Covers Subclade K The agency’s advisors express concern about low vaccine uptake and this season’s mismatched strains.

At yesterday's FDA VRBPAC meeting, advisers voted for changes to all three flu vaccine strains, hoping to cover subclade K, which is still widely circulating.

#IDsky #vaccines #influenza #publichealth #epidemiology #immunology #virology

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Published in BMC #Immunology, the study found the #fungal combination was safe, reduced vaccine side effects, and did not compromise #antibody response, with antibody levels sustained and in some cases increased at six months.

2/3

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CAR T ExPeCT™ Chimeric Antigen Receptor Persistence and Expansion Test CD19-FMC63 - 33285 | Eurofins Viracor ExPeCT anti-CD19 CAR T Test will allow you to personalize patient care by following the expansion and persistence of CAR-T cell therapy. Learn more.

Engraftment & persistence are not just pharmacokinetic metrics, they are important biomarkers of therapeutic success.

Learn about CAR T ExPeCT: www.eurofins-viracor.com/our-testing/...

#ViracorExpect #immunology

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Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness - Nature Immunology Peanut oral immunotherapy reshapes T cell responses, suppressing allergy-associated type 2 helper T cells and boosting cytotoxic type 1 helper T cells, offering clues to long-term tolerance.

"OIT participants achieving sustained unresponsiveness were distinguished by lower baseline TH2-related phenotypes, elevated post-OIT cytotoxicity-related pr effector T cell gene signatures and higher CD39 expression in pr regulatory T cells." #Immunology

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Delighted to share our new bioRxiv preprint:
www.biorxiv.org/content/10.6...

We present a new approach to resolve T cell temporal states at single-cell resolution in cancer immunotherapy.
My thanks to all co-authors and collaborators.

#Immunology #CancerResearch

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𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐀𝐛𝐬𝐭𝐫𝐚𝐜𝐭𝐬 – 𝐈𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐮𝐬 𝐂𝐨𝐧𝐠𝐫𝐞𝐬𝐬 𝟐𝟎𝟐𝟔
Join us at the 2nd International Conference on Infectious Diseases & Immunology
🔗https://lnkd.in/dahRx6mf
📅: August 17–18, 2026
📍: Orlando, Florida, USA

#eminent #infectiousdiseases #immunology

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Transcriptome analysis across nasal, bronchial and alveolar models shows strong compartment-specific antiviral and inflammatory responses linked to viral replication.
Human respiratory models reveal differences not captured in standard cell systems.
#Influenza #Immunology #Organoids

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Here you can see a crystalstructure of shark UrIg2 V-C1-C2-C3 domains (PDB code: 9DMX)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #shart #urlg2 #immunology #domain #xray

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Post-translational modifications of NLRP3: to prime or not to prime? The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of NLRP3 strictly relies on two signals: a ‘priming ...

'Over the past two decades, substantial progress has been made in understanding the regulation of #NLRP3. Priming, initially thought to be simply transcriptional, emerged as a complex interplay between different post-translational modificat'
O. Dufies & @lozanzi.bsky.social
#Immunology

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#ImmunologyNews Zika and dengue viruses are mosquito-borne infections that can cross the placenta and threaten maternal and fetal health...#immunology #research

Read more here: https://ow.ly/B5ke50YqOrn

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Study finds cockroach allergy often driven by shared proteins across arthropods Researchers analyzed molecular sensitization patterns in Polish patients with perennial allergic rhinitis who tested positive for cockroach allergens. They found that most apparent cockroach allergies...

🔬 Are you really allergic to cockroaches, or reacting to proteins shared with dust mites, seafood, and insects? New research shows cross-reactive allergens may hold the answer. 🦐🤧
www.news-medical.net/news/2026031... #CockroachAllergy #Immunology

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Integration of biochemical and physical cues by patrolling CD8+ T cells CD8+ T cell migration is central to host defense, enabling clonal selection, tissue infiltration, and elimination of infected cells. While chemokines guide these cells by activating Rac for F-actin po...

'The demonstration that tissue confinement can drive homeostatic, tissue-specific CD8+ T cell surveillance expands this paradigm beyond extracellular biochemical cues: certain CD8+ T cell subsets integrate physical and chemical inputs to tailor surveillance strategies'
#Immunology

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Innovating Tomorrow's Vaccines. What if future vaccines could be personalized to different immune systems? Meet the research team working to shape that future. Balaji Narasimhan, Jing Wang, and Michael Wannemuehler.

Innovating Tomorrow's Vaccines. What if future vaccines could be personalized to different immune systems? Meet the research team working to shape that future. Balaji Narasimhan, Jing Wang, and Michael Wannemuehler.

New Iowa State PIRS project: designing peptide-based adjuvants from endogenous proteins to power personalized nanovaccines.

Led by Jing Wang with collaborators Balaji Narasimhan & Michael Wannemuehler at the Nanovaccine Institute. Details: go.iastate.edu/ODBYVA

#vaccine #immunology

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Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy - Genes & Immunity Genes & Immunity - Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy

🌅 #Research #Alert
Regulatory #mechanisms of ALKBH5/CIITA axis in the #synergistic modulation of #hepatocellular #carcinoma #radiotherapy and #immunotherapy
#livercancer #liver #cancer #immunology

@springernature.com #Genes & #immunity
www.nature.com/articles/s41...

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Barrier breakdown: insights into the skin–gut axis in psoriatic arthritis Psoriatic arthritis (PsA) is a chronic inflammatory disease that primarily affects the skin, joints, and entheses. Growing evidence implicates alterations at the gut and skin barriers in PsA pathogenesis. These sites play a crucial role in tissue homeostasis, and their disruption can contribute to the translocation of immune cells and bacterial products, resulting in systemic inflammation. Crosstalk between barrier sites and joints can promote or exacerbate disease development, with barriers also being a potential target of disease. This review article provides a barrier-centered perspective across gut, skin, and synovium, with a specific focus on new concepts about intertissue communication involving immune and microbial mediators that can propagate inflammation in PsA.

Barrier breakdown: insights into the skin–gut axis in psoriatic arthritis #immunology

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Sex Differences in Metabolite–Immune Circuits of Neuroinflammation Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post-infectious neurological syndromes, males and females exhibit consistent d...

New review from LJI's Sharma Lab —

"We highlight key knowledge gaps and discuss how targeting metabolite–immune pathways may enable sex-informed biomarkers and therapeutic strategies in neuroinflammatory disease."

onlinelibrary.wiley.com/doi/10.1111/... #health #immunology #ImmuneSystem

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New in @jem.org from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...

#Immunology #Mitochondria #Ak4

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New from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...

#Immunology #Mitochondria #Ak4

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Thrilled to share our latest publication 🎉 5-year data in CRSwNP confirms dupilumab delivers durable disease control with excellent safety. Personalised dosing-interval extension kept efficacy high while cutting treatment burden.
#Immunology #CRS #Biologics
🔗 onlinelibrary.wiley.com/doi/10.1002/...

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New research supports the "united airways" hypothesis: nasal swabs can mirror asthma gene signatures found in the lungs, offering a non-invasive tool to detect asthma endotypes.
#Immunology #asthma #transcriptomics

🔗 ino.to/WPJV6Yf

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Per CDC: Flu hospitalizations for children this season are the 2nd highest since 2010-11.

90 children have died; 85% have been unvaccinated.

#IDsky #pediatrics #vaccines #immunology #epidemiology #publichealth

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The uterus' immune system can regenerate after transplantation The immune system in the uterus can regenerate after both uterus transplantation and bone marrow transplantation. This is shown by a new study from Karolinska Institutet that has been published in the...

The immune system in the #uterus can regenerate after uterus or bone marrow transplantation, finds a KI study published in Science Translational Medicine. The new insights may be significant for the treatment of infertility and pregnancy complications 🧪 #Immunology news.ki.se/the-uterus-i...

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⏰ Reminder: There’s still time to register & submit an abstract for the 21st International Conference on Innate Immunity!
🎓 Travel awards available
📅 May 22–27, 2026 | 📍 Kalimera Kriti Hotel & Conference Center 🇬🇷
#InnateImmunity #Immunology aegeanconferences.org/src/App/conf...

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