This study reveals distinct phenotypes in terms of how human respond to looming threats and how this process is modulated by two neuropeptides (vasopressin, angiotensin II). The image illustrates the threat looming and analytical pipeline - transforming pupillary and behavioral data from threat looming (symbolized by the snake) into specific phenotypes. By applying a computational framework integrating FPCA, clustering, and Markov Chain Analysis, the authors identified unique profiles (e.g., Profile E1) that exhibit different patterns of vigilance and cognitive engagement. These profiles show a distinct modulation by vasopressin, angiotensin II blockade and placebo. Image credit: Mengfan Han.
Neuromodulatory pathways help to process #threat, but what roles do specific neuropeptides play? A study in humans explores the impacts of manipulating two #neuropeptide pathways on responses to #looming stimuli; implications for #trauma #anxiety related disorders @plosbiology.org 🧪 plos.io/4tVHAm4