#mHTT

Latest posts tagged with #mHTT on Bluesky

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Posts tagged #mHTT

Rare Disease Advisor

@rarediseaseadvisor.bsky.social

2 weeks ago

Chimera Crosses Blood-Brain Barrier to Degrade mHTT Aggregates in Huntington Disease A compound with therapeutic potential in Huntington disease (HD) preferentially degrades mHTT aggregates and improves survival in model mice.

As reported in the @jacs.acspublications.org researchers demonstrated that a proteolysis-targeting chimera (#PROTAC) penetrates the brain to preferentially degrade mutant huntingtin (#mHTT) aggregates in #HuntingtonDisease (HD) mice.

Read here: https://bit.ly/4kTKS5d

#RareDisease #MedSky

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Daniele Bertoglio

@danielebertoglio.bsky.social

10 months ago

Can we identify biomarkers responsive to mHTT lowering?

In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.

#openaccess article: 👉 lnkd.in/eqTirauF

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