#oncotwitter

Kate Sears

@katesears.bsky.social

6 months ago

🔬 Conclusion: Perioperative Durvalumab in MIBC = clinically effective + socioeconomically justified

#BladderCancer #GUcancer #OncoTwitter #Immunotherapy #HealthEconomics #Medicalwatch 🚀

www.ejcancer.com/article/S095...

Kate Sears

@katesears.bsky.social

6 months ago

Geriatric Assessment: ASCO Global Guideline | JCO Global Oncology ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO Guidelines Methodology Manual, ASCO Guidelines follow ...

✅ Barriers: resource gaps, training, access in LMICs

➡️ Clinical practice impact: GA should be mandatory in global oncology to optimize outcomes for older adults.

#GeriatricOncology #ASCO #OncoTwitter #Medicalwatch #CancerCare #GlobalOncology
ascopubs.org/doi/10.1200/...

Kate Sears

@katesears.bsky.social

6 months ago

FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling Fibroblast growth factor receptor (FGFR) alterations are established therapeutic targets in cholangiocarcinoma and urothelial carcinoma but remain understudied in colorectal cancer (CRC). This study i...

💡 Clinical Tip: FGFR1 amplification defines a high-risk CRC subset. IRS-based IHC scoring may serve as practical biomarker to identify candidates for novel FGFR1-targeted strategies.

#ColorectalCancer #FGFR1 #Biomarkers #PrecisionOncology #OncoTwitter #Medicalwatch
www.esmoopen.com/article/S205...

Kate Sears

@katesears.bsky.social

6 months ago

✅ 5-yr survival overall: 98%, but only 36–43% in metastatic stage

#MedicalWatchPapers #OncoTwitter #ProstateCancer #CancerStats

💡 Clinical tip: Early detection + equitable access remain key. Discuss PSA screening with men 55–69y, start earlier for Black men & those with strong family history.

Kate Sears

@katesears.bsky.social

6 months ago

Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up† Surgical diagnosis should be limited to cases with small high-risk nodules, including those with negative positron emission tomography (PET)–CT findings and/or inability to obtain tissue by less invas...

✅ Systemic Tx: Peri-op #IO & targeted adjuvant (osimertinib, alectinib) improve DFS/OS
✅ Stage III: CRT ➕ durvalumab (WT) / osimertinib (EGFR+) = new SoC

#GlobalUpdate #MedicalwatchPapers #LungCancer #OncoTwitter #ESMO25
www.annalsofoncology.org/article/S092...

Kate Sears

@katesears.bsky.social

6 months ago

Geriatric Assessment: ASCO Global Guideline | JCO Global Oncology ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO G...

#GeriOncology #ASCOGuideline #GlobalOnc #CancerCare #OncoTwitter #Medicalwatch
ascopubs.org/doi/pdf/10.1...

Kate Sears

@katesears.bsky.social

6 months ago

Inferior control arms in oncology trials in LMICs: contextualised or compromised? In recent years, cancer drug randomised controlled trials (RCTs) have been criticised for employing a control arm treatment that is inferior or suboptimal to the existing standard of care.1 2 Using an...

✅ Highlights the urgent need for equity & global trial harmonization.

❓ Question to think: Should trial standards always reflect the best global care — or adapt to local realities?

#OncoEthics #GlobalOncology #ClinicalTrials #OncoTwitter #Medicalwatch
bmjoncology.bmj.com/content/4/1/...

Kate Sears

@katesears.bsky.social

6 months ago

💡 Clinical Tip: In MBC (esp. HER2+ & TNBC), discuss brain metastasis risk proactively — patient-centered dialogue is key while awaiting trial evidence.
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch

Kate Sears

@katesears.bsky.social

6 months ago

Artificial intelligence across the cancer care continuum This review highlights the expanding role of artificial intelligence across the cancer care continuum, from risk prediction to end-of-life care. It emphasizes both the promise of artificial intellige...

🔮 Future: digital twins, living evidence pipelines & multimodal decision-support at point of care
#AI #Oncology #CancerCare #DigitalHealth #OncoTwitter #MedicalWatch
acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

Medical.watch

@medicalwatch.bsky.social

7 months ago

Outcomes of subsequent treatment regimens after trastuzumab deruxtecan in patients with metastatic breast cancer AbstractBackground. Most patients with metastatic breast cancer (MBC) are eligible for treatment with trastuzumab deruxtecan (T-DXd). No data are available

#BreastCancer #HER2 #T-DXd #SacituzumabGovitecan #OncoTwitter #MedicalWatch #MBC
academic.oup.com/jnci/advance...

Poznan University of Medical Sciences

@pums-poznan.bsky.social

7 months ago

"A new machine learning tool developed by scientists at #PUMS and the University of São Paulo offers a new approach by using protein expression to predict the aggressiveness of tumours"
www.drugtargetreview.com/news/178935/...
#AI #oncology #oncotwitter #diagnostics #PROTsi

Sasanka

@sasankaatapattu.bsky.social

1 year ago

Digital Health Applications in Oncology: An Opportunity to Seize Digital health advances have transformed many clinical areas including psychiatric and cardiovascular care. However, digital health innovation is relatively nascent in cancer care, which represents th...

Remote monitoring + PROs in oncology reduced ED visits & improved symptom management with 80% adherence to weekly/monthly questionnaires. Digital health tools showing real clinical impact. buff.ly/4f6j9us #OncoTwitter #SupportiveCare #DigitalHealth