Latest posts tagged with #patchclamp on Bluesky
Twenty years of experience rarely lead to small changes.
This is just a glimpse of what we’ve been working on, shaped by:
✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology
Full reveal at #BPS2026.
#PatchClamp #20years
We love to hear how our reagents perform in the lab. An electrophysiologist at Stanford University shared great feedback on our ready-made Cesium Gluconate 👨🔬🔬
We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn
#electrophysiology #patchclamp
The Cantu-syndrom H60Y mutation in the SUR2 subunit of ATP-sensitive potassium channels results in gain of function only when paired with Kir6.1. New Dynaflow publication in Journal of Biological Chemistry.
👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels
Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
Post a non-religious photo you think of as holy
#PainResearch #Neurons #PatchClamp
A framed imaging showing two pyramidal neurons filled with biocytin (cyan) embedded in a sea of NeuN signals (magenta).
The last two cells I patched! They are by no means my best fills, but definitely the most memorable. Also a reminder to new patchers that lousy fills do not indicate bad cells- some of my best recordings didn’t have great fills. (Ah I miss patching🥹)
#patchclamp #electrophysiology
One of the most beautiful things in the world❤️ #patchclamp #EIRatio
🔬 The patch-clamp technique enables precise recording of ion channel and neuronal activity—key for studying excitability and synaptic transmission.
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...
#PatchClamp #Neural
Our patch-clamp single-cell proteomics preprint is out! Long story short: we show you how combining patch-clamp with mass spectrometry can reveal ion channels, GPCRs, and other proteins directly linked to neuronal excitability and signaling #patchclamp #electrophysiology #singlecellproteomics
Planning to record LTP or LTD in acute brain slices with whole-cell patch clamp? Give my latest article on Scientifica's NeuroWire a look! www.scientifica.uk.com/learning-zon... #plasticity #patchclamp #electrophysiology #ephys 🔬🪄⚡️
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)
One last chance, course is not fully subscribed yet!
#biophysics #patchclamp #TIRF
patch clamp technique #patchclamp #metinaytekin
How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?
Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.
📍https://ow.ly/PxZY50W72H7
#PatchClamp #Channelopathies #IonChannels
#neuroscience #micromanipulation #electrophysiology #ScanImage #autopatch #patchclamp #LifeSciences #labautomation #neurotech #researchtools
Monosynaptic IPSCs evoked in a pyramidal neuron by stimulating a nearby PV interneuron
Some beautiful IPSCs for your Friday! #patchclamp
In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.
Read more here:
www.nanion.de/news/automat...
All those GABAs from mouse V1 #patchclamp
(Should mention these are recorded with a high Cl internal thus the outward currents)
An exhibition table at the German Neuroscience Society meeting. The table is set up with two different microscope systems. One focused on live cell and confocal imaging, the other on combining imaging and patch clamp recordings. Behind the table are two company representatives. One from Ultimeyes/Cairn GmbH, the other from Teledyne Photometrics.
We are all set at the Göttingen Meeting of the @neurowissg.bsky.social... Drop by booth 62 to see what we have brought along ( #patchclamp and #imaging ), but also to share stories of your biggest experimental victories 🥳 and challenges 😶🌫️!
Such a good feeling to get data again #patchclamp
Working with toxins & ion channels? Testing multiple fractions and screening channels with limited samples is tough. That’s why more scientists are turning to automated patch clamp for faster, reliable results. Curious? Learn more: www.nanion.de/application-... #ionchannels #toxins #patchclamp
In a pioneering study, Achouba et al. successfully integrated photoswitch technology into a complex, disulfide-rich peptide ChTx while retaining high nanomolar potency for ion channels.
Read more here:
www.nanion.de/news/optical...
#ionchannels #optogenetics #patchclamp #APC #venom #toxins
Key point: Optogenetic stimulation of dentate gyrus granule cells leads to strong synaptic activation of mossy cells.
doi.org/10.1111/epi....
#epilepsy #ILAE #channelrhodopsin2 #excitotoxicity #patchclamp #retigabine #temporallobeepilepsy
A recent study provides detailed structural insights into how potassium-selective channelrhodopsins (KCRs) function.
Read here:
www.nanion.de/news/light-g...
#ionchannels #optogenetics #patchclamp #APC
An electrophysiology rig being taken apart for cleaning
When the outside world is crazy, you go find solace by deep-cleaning your slice rig.
By the way, any ground box suggestion?
#patchclamp #electrophysiology #neuroskyence #neuroscience
Controlling the environment inside cells is a major challenge. Olofsson et al. have created a pore formation method for microfluidic single-cell solution exchange that makes it possible to initiate enzymatic reactions and to generate intracellular oscillations and gradients.
#JournalClub #PatchClamp
Getting quite close to the deadline for this fully funded PhD studentship combining AI development (the #ArtificialIntelligence type the Gov is pushing!), #PatchClamp #Ionchannel research and stem cells... did I miss any buzzwords?
Code or Wanna learn???
Deadline 31st January.
