✅The measurement in feces of a panel of biomarkers reflecting inflammatory and epithelial cell activities is important for understanding the underlying pathophysiology of IBS. ✅The absence of signs of involvement of neutrophils and eosinophils in IBS suggests that increased activity of intestinal epithelial cells rather than inflammation is a major determinant of the disease. ✅The negative correlation between the novel biomarker human phospholipase BII-precursor (HPLBII-P) and bloating and the presence of this biomarker in intestinal epithelial cells suggest a physiological role of HPLBII-P in intestinal activities.
🆕🔥Elevated #FecalBiomarkers of colo‐rectal #EpithelialCell activity in #IBS‼️ #NGMJournal
🎯Activity of #GutEpithelialCells rather than #inflammation driven by #neutrophils and/or #eosinophils, is a key #pathogenetic mechanism in #IBS👏
👉onlinelibrary.wiley.com/doi/full/10.1111/nmo.149...
