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Our whitepaper on #ProjectPsyche is online now in @cp-trendsecolevo.bsky.social! Psyche will generate reference genomes for all European butterflies. Just imagine what we’ll be able to learn from them. And if you can’t quite imagine it, have a look at the piece. :)

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Earth BioGenome Project The Earth BioGenome Project is a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth’s eukaryotic biodiversity over a period of 10 years.

(2/5) Why this matters: #ProjectPsyche addresses urgent challenges in the context of global #insectDeclines, like population fragmentation and ecological resilience, by building a standardized genomic resource under the @ergabiodiv.bsky.social l umbrella 🌍!
www.earthbiogenome.org

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Project Psyche: reference genomes for all Lepidoptera in Europe Project Psyche is a transnational initiative to generate and study chromosome-level reference genomes of all ~11 000 species of Lepidoptera (butterflies and moths) found in Europe. Here, we describe t...

(1/5)Thrilled to announce our paper on #ProjectPsyche is out! 🦋We describe how we’ve generated 1000+ high-quality genomes for European Lepidoptera, providing an unprecedented resource for biodiversity, conservation, and evolutionary research.
#Genomics #Biodiversity
www.cell.com/trends/ecolo...

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Project Psyche is featured in a new article out now on @spectrum.ieee.org! Check it out to get an insight into the efforts of @ebpgenome.bsky.social and the milestones achieved during the fieldtrip of #ProjectPsyche and @10klepgenomes.bsky.social to the Italian Alps 🦋

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Celebrating the first 1,000 sequenced genomes on @projectpsyche.bsky.social 😎🧬🦋 #ProjectPsyche #MothStitching

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Project Psyche: Generating and utilising reference genomes for all Lepidoptera in Europe

(6/6)📄 In our new whitepaper (EcoEvoRxiv) we discuss our aims to coordinate this collaborative analysis of Lepidoptera genomes, turning data into impact for science, conservation and society.
Now available at 👉 ecoevorxiv.org/repository/v...

#ProjectPsyche #Genomics

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The potential of Psyche genomes to address evolutionary questions and impact society.
A. Evolution of chromosome structure through fusions, fissions and inversions.
B. 3D genome, chromosome territories.
C. Compartments and topologically associated domains (TADs).
D. Time-calibrated species phylogeny.
E. Diversification rates over time of two lineages.
F. Discordance between phylogenies (e.g. horizontal gene transfer, cobionts, mitochondria, hybridisation).
G. Gene duplication, loss, transfer, and gain of new regulatory elements.
H. Gene evolution/copy number variation in the context of a tree, and correlation with phenotypic traits.
I. Gene expression across different conditions/states and association with phenotypic traits.
J. Population size changes over time in three lineages.
K. Tracking species range expansion or genetic connectivity across space.
L. Correlates of genetic diversity with traits such as range size.
M. Food security. Lepidoptera are an important source of food and protein which has potential for expansion facilitated by genomics. In addition, genomics aids tracking and management of species of Lepidoptera which are major agricultural pests.
N. Discovery of new compounds for biotechnology.
O. Integrating genomics with ecology and taxonomy will feed into knowledge dissemination to the public and influence policy
P. Genetic comparisons between populations, informing conservation units and species re-introductions
Q. Conservation case studies, Large Blue and Apollo butterflies

The potential of Psyche genomes to address evolutionary questions and impact society. A. Evolution of chromosome structure through fusions, fissions and inversions. B. 3D genome, chromosome territories. C. Compartments and topologically associated domains (TADs). D. Time-calibrated species phylogeny. E. Diversification rates over time of two lineages. F. Discordance between phylogenies (e.g. horizontal gene transfer, cobionts, mitochondria, hybridisation). G. Gene duplication, loss, transfer, and gain of new regulatory elements. H. Gene evolution/copy number variation in the context of a tree, and correlation with phenotypic traits. I. Gene expression across different conditions/states and association with phenotypic traits. J. Population size changes over time in three lineages. K. Tracking species range expansion or genetic connectivity across space. L. Correlates of genetic diversity with traits such as range size. M. Food security. Lepidoptera are an important source of food and protein which has potential for expansion facilitated by genomics. In addition, genomics aids tracking and management of species of Lepidoptera which are major agricultural pests. N. Discovery of new compounds for biotechnology. O. Integrating genomics with ecology and taxonomy will feed into knowledge dissemination to the public and influence policy P. Genetic comparisons between populations, informing conservation units and species re-introductions Q. Conservation case studies, Large Blue and Apollo butterflies

(5/6)The #ProjectPsyche community is also forming international teams to jointly use these genomes to:
🧬 Drive discovery with genome data.
🌍 Inform conservation strategies.
📌 Help tackle societal challenges.
Link Psyche: www.projectpsyche.org

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Sequencing the diversity of Lepidoptera found in Europe.
A. Comparison of the status of sequencing for Lepidoptera compared to the other orders within Arthropoda. Showing the ten orders with the highest numbers of chromosome-level genomes. Data derived from GoaT on 05.09.2025.
B. The tree shows family relationships between all families of Lepidoptera which have representatives in Europe. The tree structure is adapted from [54, 117]. The outer ring shows a stacked bar chart of the number of species sequenced (dark pink) out of the total number per family in Europe (light pink).
The figure was generated using iToL (https://itol.embl.de/). Representative species are shown alongside the phylogeny; Micropterix aruncella (Micropterigidae), Triodia sylvina (Hepialidae), Adela croesella (Adelidae), Tinea trinotella (Tineidae), Yponomeuta malinellus (Yponomeutidae), Notocelia
uddmanniana (Tortricidae), Apatura iris (Nymphalidae), Zygaena filipendulae (Zygaenidae),
Recurvaria leucatella (Gelechiidae), Blastobasis adustella (Blastobasidae), Parapoynx stratiotata (Crambidae), Thyatira batis (Drepanidae), Lymantria monacha (Erebidae).
C. Map of locations of sample collection hubs (yellow stars) and sequencing hubs (blue star).
Locations of member organisations that are part of the Project Psyche consortium are represented by red circles.

Sequencing the diversity of Lepidoptera found in Europe. A. Comparison of the status of sequencing for Lepidoptera compared to the other orders within Arthropoda. Showing the ten orders with the highest numbers of chromosome-level genomes. Data derived from GoaT on 05.09.2025. B. The tree shows family relationships between all families of Lepidoptera which have representatives in Europe. The tree structure is adapted from [54, 117]. The outer ring shows a stacked bar chart of the number of species sequenced (dark pink) out of the total number per family in Europe (light pink). The figure was generated using iToL (https://itol.embl.de/). Representative species are shown alongside the phylogeny; Micropterix aruncella (Micropterigidae), Triodia sylvina (Hepialidae), Adela croesella (Adelidae), Tinea trinotella (Tineidae), Yponomeuta malinellus (Yponomeutidae), Notocelia uddmanniana (Tortricidae), Apatura iris (Nymphalidae), Zygaena filipendulae (Zygaenidae), Recurvaria leucatella (Gelechiidae), Blastobasis adustella (Blastobasidae), Parapoynx stratiotata (Crambidae), Thyatira batis (Drepanidae), Lymantria monacha (Erebidae). C. Map of locations of sample collection hubs (yellow stars) and sequencing hubs (blue star). Locations of member organisations that are part of the Project Psyche consortium are represented by red circles.

(4/6)🚀 For #ProjectPsyche, this is just the beginning. This ambitious pan-European project involves:
🔹 184+ researchers
🔹 34 countries
The goal? To sequence all 11,000 European Lepidoptera species!
These chromosome-level genomes are openly available for anyone to use.

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a colorful background with the words stay tuned written on it ALT: a colorful background with the words stay tuned written on it

(7/7) 🚀 Looking ahead: We’re eager to see where the journey takes us next year. With Phase 1 of the
@projectpsyche.bsky.social approaching, we’re on track to reach 1,000 Lepidopterans genomes soon—stay tuned for big news! 🌟🦋

#ProjectPsyche #ReferenceGenomes

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Project Psyche ~ The Adventure Begins!
Project Psyche ~ The Adventure Begins! YouTube video by The GMologist

Dee playtests Project Psyche with the GMologists!
youtu.be/HcrAOPew2KM
#ttrpg #kismetgames #projectpsyche #yze

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10KLeps - 10kLepGenomes Cost Action CA23122

(3/5) Access to powerful resources:
#LepEU consortium field samples
#ProjectPsyche reference genomes
#10kLepGenomes COST Action network
• Functional validation tools like CRISPR/Cas9 available for gene editing

10klepgenomes.eu

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La Facultad de Biología de la Universidad de Oviedo alberga una colección zoológica con más de medio millón de ejemplares - Universidad de Oviedo - uniovi.es Conoce toda la actualidad sobre la Universidad de Oviedo

(5/5) International collaboration between research institutions and natural history collections is key to decode and preserve the diversity of European #Lepidoptera 🦋🧬
Learn more about the partnership between @universidadoviedo.bsky.social and #ProjectPsyche here:
www.uniovi.es/en/actualida...

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Utilizing 10,000 genomes of European Lepidoptera The 10kLepGenomes COST Action aims to take advantage of the massive amount of data being produced by genome initiatives, in order to understand pressing issues of biodiversity loss, pest control, and ...

(4/5) The @sangerinstitute.bsky.social , a lead partner of @ebpgenome.bsky.social , drives this genomic revolution. #ProjectPsyche is part of it, supported also by @10klepgenomes.bsky.social , which funds meetings, exchanges, courses & fieldwork.
www.cost.eu/actions/CA23...

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Project Psyche Project Psyche - Lepidopteran genomes for Europe

(3/5) #ProjectPsyche aims to sequence ~11,000 European butterflies and moths 🦋
Taxonomic expertise from partner institutions like Oviedo supports the effort, and scientific collections alike may contribute preserved specimens for future museomic approaches.
www.projectpsyche.org

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Entomology Collection_BOS Entomology Lab (University of Oviedo)

(2/5) Their work connects #ProjectPsyche -led by the @sangerinstitute.bsky.social -and the @universidadoviedo.bsky.social insect collection, home to over 500,000 entomological specimens.
It’s a local archive fueling international science.

entomocollectionbos.wordpress.com

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Laura (left) and Mónica (right) at the Psyche Project meeting held at Lund University in March 2025.

Laura (left) and Mónica (right) at the Psyche Project meeting held at Lund University in March 2025.

(1/5) The @universidadoviedo.bsky.social is contributing directly to the future of biodiversity genomics through its entomological collection and experts.
@erebiologa.bsky.social and @entomoprofessor.bsky.social, taxonomists based at Oviedo, are active members of #ProjectPsyche

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Aethes smeathmanniana - LepiWiki

🧬 New genome drop!
The @sangerinstitute.bsky.social just completed the #Aethes_smeathmanniana genome assembly — ilAetSmea3.1 is here!
Built with PacBio + Hi-C, the assembly includes two curated haplotypes.
#GenomeOfTheWeek #Genomics #ProjectPsyche #Genomics
lepiforum.org/wiki/page/Ae...

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Acontia lucida - LepiWiki

🧬 New genome drop!
The Sanger team just completed the #Acontia_lucida genome assembly — ilAcoLuci2.1 is here!
Built with PacBio + Hi-C, the assembly includes two curated haplotypes.

#GenomeOfTheWeek #Acontialucida #Genomics #ProjectPsyche #GenomeAssembly

lepiforum.org/wiki/page/Ac...

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Portrait of Bulah next to the Hi-C map of the genome of Diacrisia sannio, a species sampled by Kay Lucek at the University of Neuchâtel.

Portrait of Bulah next to the Hi-C map of the genome of Diacrisia sannio, a species sampled by Kay Lucek at the University of Neuchâtel.

🎉 Congrats to our #CuratorOfTheMonth — Bulah!
Thanks for your great work! 👏

#ProjectPsyche #GenomeCuration #Lepidoptera

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Valéria and Loukia presenting the different hubs involved in the Psyche Project, with a slide showing a map of Europe and the hubs highlighted with red dots.

Valéria and Loukia presenting the different hubs involved in the Psyche Project, with a slide showing a map of Europe and the hubs highlighted with red dots.

(3/3) They also shared insights on the network of regional hubs—collaborative nodes around the globe coordinating sampling, sequencing, and training.
Together, we’re building a truly global initiative 🦋🌍
#10kLepGenomes #ProjectPsyche #sciencecollaboration

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Valéria and Loukia with a slide presenting phase 1 of the project to the meeting attendees

Valéria and Loukia with a slide presenting phase 1 of the project to the meeting attendees

(2/3)They introduced Phase 1 of #ProjectPsyche: Over the next 2 years, the Tree of Life programme at the Wellcome Sanger Institute will sequence and assemble to chromosomal completeness the genomes of 2,000 Lepidoptera species. A bold first step toward a comprehensive genomic atlas! 🧬🌍

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Logo of the Institute of Evolutionary Biology of the CSIC

Logo of the Institute of Evolutionary Biology of the CSIC

(1/3) Our collaborators
@anguisvaleris.bsky.social and Loukia presented the #ProjectPsyche and the COST Action #10kLepGenomes at the @ibe-barcelona.bsky.social (IBE-CSIC-UPF)! 🧬🦋
Grateful for the chance to share our vision and spark new connections!

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Collage of Lepidoptera-inspired tattoos featuring Actias isabellae, Erebia palarica, Acherontia atropos, Heliconius hermathena vereatta, Urbanus esmeraldus, Erebia euryale, Danaus plexippus and other Lepidoptera-related designs.

Collage of Lepidoptera-inspired tattoos featuring Actias isabellae, Erebia palarica, Acherontia atropos, Heliconius hermathena vereatta, Urbanus esmeraldus, Erebia euryale, Danaus plexippus and other Lepidoptera-related designs.

#Moths and #butterflies hold a special place in the hearts of #ProjectPsyche members, and some have chosen to carry them on their skin forever! 🦋
Check out this collage of Lepidoptera-inspired tattoos from our community, featuring real species and artistic interpretations alike 🎨

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(5/5) One of the goals for the upcoming phases of #ProjectPsyche is to keep strengthening the community by increasing both the number of sampling and sequencing hubs. Learn more about the collection hubs here: www.projectpsyche.org/theorganisat...

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Institutional logos of the decentralized hubs of Project Psyche

Institutional logos of the decentralized hubs of Project Psyche

(3/5) Decentralised collection hubs are currently located at institutional partners in Spain, Switzerland, Sweden, Finland, Italy, Czech Republic and Romania #ProjectPsyche

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Photo of a sign showing the information of the 10KLepGenomes Workshop in Lund with a black arrow pointing to the left

Photo of a sign showing the information of the 10KLepGenomes Workshop in Lund with a black arrow pointing to the left

(1/5) It’s been a month since the Spring Meeting—let’s look back at some milestones from #ProjectPsyche Phase 1!

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Psyche Hubs

(5/5) One of the goals for the upcoming phases of #ProjectPsyche is to keep strengthening the community by increasing both the number of sampling and sequencing hubs. Learn more about the collection hubs here: www.projectpsyche.org/theorganisat...

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(3/5) Decentralised collection hubs are currently located at institutional partners in Spain, Switzerland, Sweden, Finland, Italy, Czech Republic and Romania #ProjectPsyche

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Darwin Tree of Life – Reading the genomes of all life: a new platform for understanding our biodiversity

(3/3) The DToL project is sequencing the flora and fauna of UK and Ireland, and it established the systems and protocols that are now helping the progress of #ProjectPsyche 🍃🕷️
www.darwintreeoflife.org

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Project Psyche Project Psyche is a multinational effort to sequence the genomes of all 11,000 species of Lepidoptera - moths and butterflies - in Europe. Building on the Tree of Life Programme's expertise on similar...

(2/2) So far, genome sequencing for #ProjectPsyche has been performed at the Wellcome Sanger Institute, home of other projects such as the Darwin Tree of Life (DToL) 🧬
www.sanger.ac.uk/collaboratio...

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