#randomizedTrial

Gordon H. Guyatt

@guyattgh.bsky.social

1 week ago

A comparison of seven-point and visual analogue scales. Data from a randomized trial - PubMed Many controlled trials rely on subjective measures of symptoms or quality of life as primary outcomes. The relative merits of different response options for these instruments is an important issue. Therefore, we compared the responsiveness and validity of seven-point versus visual analogue scales (V …

Compelling evidence from a #RandomizedTrial (RCT) looking at #PatientImportantOutcomes (PROMS): 7-point scales and #VisualAnalogueScales (VAS) show similar validity and responsiveness (sensitivity to change) to detect intervention effects. Either choice is fine.

pubmed.ncbi.nlm.nih.gov/2157581/

@arxivlens.bsky.social

2 months ago

Efficacy of nebulised versus intravenous tranexamic acid in management of non-massive haemoptysis: A randomised controlled trial.
Dinesh, Vasudha et al.
Paper
Details
#Hemoptysis #TranexamicAcid #RandomizedTrial

JMIR Publications

@jmirpub.bsky.social

2 months ago

Automated Feedback After Internet-Based Depression Screening: Cost-Effectiveness Analysis of a Randomized Controlled Trial Background: The clinical and cost-related consequences of internet-based depression screening, in combination with automated feedback, have been rarely investigated. We aimed to conduct a cost-effectiveness analysis (CEA) of DISCOVER, a three-armed, observer-masked, randomized controlled trial that focused on two versions of automated feedback interventions after internet-based depression screening. Objective: This study aims to evaluate the cost-effectiveness of automated non-tailored and tailored feedback interventions, after internet-based depression screening, from a societal perspective. Methods: Participants were recruited from the general population via traditional and social media. Participants who were undiagnosed but screened positive for depression on an online version of the Patient Health Questionnaire-9 (PHQ-9; ≥10 points) were randomized to automatically receive either no feedback, non-tailored feedback, or tailored feedback. The feedback interventions included the depression screening result, a recommendation to seek professional advice, and brief general information about depression. The tailored feedback was additionally framed as per the participants’ symptom profiles, treatment preferences, as well as health insurance plan, and local residency. The time horizon was six months. The main outcome was the incremental cost-effectiveness ratio (ICER) from a societal perspective using quality-adjusted life-years (QALY) based on the EQ-5D-5L. Cost-effectiveness acceptability curves (CEAC) were constructed. Furthermore, several sensitivity analyses and explorative subgroup analyses were conducted. Results: 1,012 participants (no feedback: 343; non-tailored feedback: 338; tailored feedback: 331) were included. Differences in costs and effects were not statistically significant. Still, ICER results indicated that both no feedback and tailored feedback exhibited dominance over non-tailored feedback. The ICER of tailored feedback compared to no feedback was €109,730/QALY, whereas both costs and QALYs were lower in tailored feedback. The cost-effectiveness probability of tailored feedback compared to no feedback ranged between 41% and 80%. Sensitivity analyses exhibited similar trends. Conclusions: Six months post-intervention, feedback interventions had no statistically significant effect on costs from a societal perspective nor on QALYs. Tailored feedback was associated with moderate cost-effectiveness probabilities compared to no feedback. Explorative subgroup analyses revealed subpopulations for which the interventions might be cost-effective. Clinical Trial: ClinicalTrials.gov: NCT04633096

JMIR Formative Res: Automated Feedback After Internet-Based Depression Screening: Cost-Effectiveness Analysis of a Randomized Controlled Trial #MentalHealth #DepressionScreening #AutomatedFeedback #CostEffectiveness #RandomizedTrial

Gordon H. Guyatt

@guyattgh.bsky.social

3 months ago

Cost-Effectiveness of Pantoprazole for Upper GI Bleeding During Ventilation This economic evaluation examines cost-effectiveness of daily intravenous pantoprazole vs no pantoprazole for preventing upper gastrointestinal bleeding in critically ill, mechanically ventilated pati...

Just published big news for #IntensiveCare. #RandomizedTrial demonstrates that a #ProtonPumpInhibitor not only decreases gastrointestinal #bleeding, but because of #costs generated by those bleeds also appreciably decreases #ICU costs.

jamanetwork.com/journals/jam...

Gordon H. Guyatt

@guyattgh.bsky.social

4 months ago

A clinician's guide for conducting randomized trials in individual patients In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be car...

Anyone interested in determining the effect of a drug in a single patient by conducting a #RandomizedTrial in a that patient – an N of 1 trial – will find this step-by-step guide enormously useful.

www.cmaj.ca/content/139/...

Gordon H. Guyatt

@guyattgh.bsky.social

4 months ago

Tranexamic Acid in Patients Undergoing Noncardiac Surgery | NEJM Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. We conducted a trial involving patien...

The ground-breaking #NEJM #randomizedTrial suggests that every #surgery patient at substantial #bleeding risk should receive #tranexamicAcid: 24% #RelativeRisk reduction in serious bleeding.

www.nejm.org/doi/full/10....

Christophe Bousquet

@krisanathema.fediscience.org.ap.brid.gy

5 months ago

The latest #LargeScale experiment of #testosterone manipulation fail to replicate previous findings typically in smaller-scale studies] on #economic [#preferences in men, calling into question the idea that short-term testosterone fluctuations are important drivers of men’s economic preferences […]

Acta Materia Medica

@amm-journal.org

1 year ago

Randomized, waitlist-controlled trial of Cordyceps sinensis mycelium culture extract (Cs4) for long COVID patients in Hong Kong Cordyceps sinensis mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. In this randomized trial 110 participants were assigned to receive Cs4 (55 participants) or were wa...

Randomized, waitlist-controlled trial of #Cordycepssinensis mycelium culture extract (#Cs4) for #longCOVID patients in Hong Kong.

Read More: amm-journal.org/index.php/20...

#randomizedtrial #modifiedCOVID19 #YorkshireRehabilitationScale #C19YRSm @scienceopen.bsky.social

Epilepsia Open

@epilepsia-open.bsky.social

1 year ago

Key point: A low dose of antiseizure medications may be started in adults with a new diagnosis of focal epilepsy of unknown etiology and low seizure frequency.
doi.org/10.1002/epi4...

#epilepsy #ILAE #efficacy #focalepilepsy #lowdose #monotherapy #newlydiagnosedepilepsy #randomizedtrial