Synapse type density in the mouse brain. PSD95 and SAP102, two postsynaptic scaffolding proteins expressed at excitatory synapses, were fluorescently imaged at single-punctum resolution across the whole mouse brain. Top row: Axial, coronal, and sagittal view of the 137-region parcellation used for analyses involving tract-tracing data (left) and the 88-region parcellation used for analyses involving fMRI data (right). Regions are coloured and labeled according to ontological structure. Other roaws show axial, coronal, and sagittal views of mean long-lifetime PSD95 synapse density, mean short-lifetime PSD95 synapse density, and mean SAP102 synapse density, mapped to both 137- and 88-region parcellations.
How do diverse synapses relate spatially to whole-brain dynamics? @misicbata.bsky.social &co map ~1 billion synaptic puncta from a single mouse brain onto #hemodynamic features, revealing links between #synapse features, #brain networks & synaptic engagement @plosbiology.org 🧪 plos.io/4rmeef6