Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.
Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo