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Join us at Neuro Winter Summit 2026 in Hokkaido, Japan, March 24–28 at Rusutsu Resort.

Visit Booth #2 to meet Benjamin Compans & Michel Biocco and discuss how #superresolution imaging can advance #neuroscience research, from #synapses to subcellular dynamics.

#Microscopy

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Secure Your Seat! Only a few weeks to go until the #SYNAPSES Conference on Sustainability Citizenship for teachers and school leaders in Greece 🇬🇷
👉 Be part of a growing community shaping the future of sustainable education: conference.synapses-academies.eu #schoolleaders #schoolheads

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Join our Memory Decoding Journal Club: “Engram cell connectivity as a mechanism for information encoding and memory function” (Ortega-de San Luis et al.) w/ Ariel Zeleznikow-Johnston — Tue, Mar 3, 3pm PT. meet.google.com/udr-jcdc-vkp
#memory #engram #neuroscience #synapses

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Join our Memory Decoding Journal Club: “Engram cell connectivity as a mechanism for information encoding and memory function” (Ortega-de San Luis et al.) w/ Ariel Zeleznikow-Johnston — Tue, Mar 3, 3pm PT. meet.google.com/udr-jcdc-vkp
#memory #engram #neuroscience #synapses

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What do ER-peroxisomes contacts do? These are a key hub for ether lipid and plasmalogen biosynthesis. Plasmalogens stabilize curved membrane surfaces and are highly enriched at #synapses and in synaptic vesicles. 9/13

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New research maps the slow cascade from brief tau toxicity to lasting synaptic dysfunction, offering a more dynamic view of neurodegeneration.

longevity.technology/news/tau-exp...

#longevity #neuroscience #alzheimersresearch #braindegeneration #synapses #agingbrain

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repost @adrianisaac.art on IG
#Synapses Sound design 🔊😎 by the radical @rzn_music #generativeart #curves #3dart #mathart #digitalart #blender3d #abstract #codeart

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Scientists May Finally Know Why You Can’t Remember Being a Baby and The Answer Is Tiny Immune Cells Acting as Memory Janitors Microglia cells act as memory managers, scrubbing early archives to make room for the new.
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Roles of circular RNAs targeted to #synapses: Narrative review of potential mechanisms and biomarkers
Li et al. review the roles of #CircularRNAs in synaptic function and their potential as #biomarkers for #neurodegenerativediseases.
www.sciencedirect.com/science/arti...

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By leveraging in situ cryo-ET, Tian et al. obtained high-resolution, #3D views of the native #ultrastructure of intact hippocampal #synapses. See here: doi.org/10.1007/s122...

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A new #fluorescent sensor, iGluSnFR3, reveals #glutamate release at #synapses in real time 🧠✨

Developed by teams from the Allen Institute, HHMI, and UC San Diego, it makes the brain’s fastest signals visible, enabling deeper insight into how #neurons communicate across networks.

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‎Gemini - direct access to Google AI Created with Gemini

#Gemini3

"What made me think that #ErikaKirk is a Zionists' golem?"

From the let's explore the world to-get-her through #LLM #tokens, artificial #synapses #department.

Go on, #observe.

gemini.google.com/share/050346...

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Scientists Find How To Dial Brain Signals Up or Down To Treat Mental and Neurological Disorders Scientists say their new insights into how a key brain protein works could help resolve a long-standing question in molecular neuroscience. Researchers supported by the National Institutes of Health at Johns Hopkins Medicine report that they have uncovered a promising drug target that could help regulate the activity of key brain proteins. By adjusting how [...]
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 Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

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 Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

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 Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

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Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...

A breathtaking glimpse into the #brain at work: NeuroCure researchers & colleagues @janakroll.bsky.social captured #synapses in action - revealing how #neurotransmitters are released in milliseconds 🧠 Published in NatureCommunications @Charite @mdc-berlin.bsky.social
www.nature.com/articles/s41...

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Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf

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Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf

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Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Expression of RIN1 in spinal cord SOM+ interneurons. Immunohistochemistry for RIN1 (red) and PSD-95 (green) in SOM+ interneurons (blue) labelled by intraspinal injection of AAV2/9-DIO-EGFP in SOM-Cre mice. Arrows indicate colocalization. Scale bar, 10 µm.

Modulating #NMDAR subunit composition is important for synaptic function, but how is this controlled? This study shows that RIN1 differentially regulates localization of GluN2B & GluN2A subunits at spinal #synapses, with insights into development & neuropathic pain @plosbiology.org 🧪 plos.io/447TTRf

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📅 5–9 Jan 2026
⏰ Deadline: 19 Dec 2025

🔗 Program: lnkd.in/duQcc9sq
🔗 Register: lnkd.in/d6ptmtFM

@ucoimbra.bsky.social

#Neuroscience #Synapses #PDBEB #idpIN

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🧪🔍 New insight into #cell communication: Researchers discovered a ring-shaped “cap” that controls electrical #synapses. This tiny structure may help explain how cells fine-tune their signals. 🔗 aktuelles.uni-frankfurt.de/english/new-....

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In 🐁, some #pericyte #PrimaryCilia penetrate #astrocytic #endfeet and reach the #neuropil - sometimes near #synapses! Could these #cilia act as sensory “antennae” 📡for #NeurovascularCoupling?
🧪🧵5/8

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L’intelligence peut-elle être expliquée par la génétique et l’épigénétique ? Quelle est la part de l’environnement, en particulier social, de l’épigénétique et de la génétique dans les manifestations de l’intelligence (ou des intelligences) chez l’enfant et chez l’adulte ?

En tant que phénotype et sans surprise, l' #intelligence est influencée par près de 200 gènes qui jouent entre autres sur la #neurogénèse, la production de myéline et des #synapses. Mais cette capacité mentale est aussi environnementale.
via @theconversation.com
theconversation.com/lintelligenc...

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Spine Dynamics: Are They All the Same? Dendritic spines are often viewed as proxies for glutamatergic synapses, and their addition or elimination as indicative of changes in circuit structure. In this review, Berry and Nedivi examine synap...

For a meme this is OK...

But spines reach out and retract dynamically. It seems unlikely that these are associated with a presynaptic terminal. Some fraction have no postsynaptic elements (checked in vivo). Also some #synapses are onto the dendritic shaft.

www.cell.com/neuron/fullt...

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On Sunday, don't miss the Presidential Special Lecture by the one and only @tspiresjones.bsky.social ! #SfN25 #SfN2025 #Alzheimer's #synapses #glia

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In this opening #Editorial, Samuel M. Young Jr. and Lu-Yang Wang introduce "The giant impact of #synapses on brain function and disease" special issue 📖 📜

🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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#Research by Cristina Román-Vendrell of mblscience.bsky.social et al. observed that acute introduction of monomeric or multimeric α-synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant #synapses 🧠 🧪

📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Flyer for SYNAPSES Symposium (Thursday October 23rd at Room 116 at 100 College Street) with talks by Ann Rose Bright, PhD at 9:00am, Peter Hasenhuetl, PhD at 10:00am, Minhyeok Chang, PhD at 11:15am, and Zhenggang Zhu, PhD at 12:15pm. Registration QR code at top right.

Flyer for SYNAPSES Symposium (Thursday October 23rd at Room 116 at 100 College Street) with talks by Ann Rose Bright, PhD at 9:00am, Peter Hasenhuetl, PhD at 10:00am, Minhyeok Chang, PhD at 11:15am, and Zhenggang Zhu, PhD at 12:15pm. Registration QR code at top right.

"TOMORROW @yaleneuro.bsky.social @kavliatyale.bsky.social Yale present #SYNAPSES, our senior postdoc symposium! 🙌

Hear from four incredible researchers 👩‍🔬🥼 as they share their latest discoveries and insights! 🗣️

You won't want to miss it! 🗓️"

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How Synapses Grow Up - Neuroscience News A new study reveals how young synapses gradually mature to send chemical signals correctly — a process that can take days and depends on neural activity.

Synapses don’t start fully functional, they learn to communicate over days, guided by neural activity.

New MIT research shows how disrupted signaling may underlie disorders like autism and epilepsy.

#Synapses #neural #MIT #autism #epilepsy

neurosciencenews.com/synapse-matu...

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