#tbscience

4 days ago

🔬 TBScience brings together researchers advancing the science of tuberculosis.

We invite abstracts exploring new insights into TB infection, transmission and treatment.
🔗 https://worldlunghealth.org/tbscience/

#UnionConf2026 #TBScience

1 1 1 0

Global TB Program

@globaltb.bsky.social

3 months ago

🔬 Day 2 at #UnionConf2025!
Today’s sessions highlight cutting-edge TB science—from implementation to economic tools. Your engagement helps bring attention to the innovations driving impact!
#TBScience #Innovation #EndTB #TBSky

0 0 0 0

Samuel G. Schumacher

@sgschumacher.bsky.social

9 months ago

Funding acknowledgement:
This work is made possible through catalytic support from the Gates Foundation—thank you for championing better, faster TB diagnostics. #Tuberculosis #Diagnostics #GlobalHealth #EvidenceGeneration #WHO #TBScience #Policy #Research

0 0 0 0

@tbrigden.bsky.social

9 months ago

TBScience – The Union World Conference on Lung Health 2025

#TBScience has now launched it's call for abstracts. The themes this year are:
- New frontiers in TB treatment development and monitoring
- Artificial Intelligence advancing the TB field
- TB vaccines and other prevention strategies
- Microscopic frontiers in TB pathology
shorturl.at/m7oh9

0 0 0 0

Shicheng Guo

@shihcheng.bsky.social

1 year ago

Structural basis of siderophore export and drug efflux by Mycobacterium tuberculosis | Nature Communications To replicate and cause disease, Mycobacterium tuberculosis secretes siderophores called mycobactins to scavenge iron from the human host. Two closely related transporters, MmpL4 and MmpL5, are required for mycobactin secretion and drug efflux. In clinical strains, overproduction of MmpL5 confers resistance towards bedaquiline and clofazimine, key drugs to combat multidrug resistant tuberculosis. Here, we present cryogenic-electron microscopy structures of MmpL4 and identify a mycobactin binding site, which is accessible from the cytosol and also required for bedaquiline efflux. An unusual coiled-coil domain predicted to extend 130 Å into the periplasm is essential for mycobactin and bedaquiline efflux by MmpL4 and MmpL5. The mycobacterial acyl carrier protein MbtL forms a complex with MmpL4, indicating that mycobactin synthesis and export are coupled. Thus, MmpL4 and MmpL5 constitute the core components of a unique multi-subunit machinery required for iron acquisition and drug efflux b

Cryo-EM reveals MmpL4 structure in TB, crucial for mycobactin secretion and drug resistance. Overproduction of MmpL5 boosts resistance to bedaquiline & clofazimine! #TBScience PMID:39994240, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56888-6 #Medsky #Pharmsky #RNAsky 🧪

18 2 0 0

Olivier Neyrolles

@oneyrolles.bsky.social

1 year ago

Terrific @embl.org #EMBO meeting on #Tuberculosis in Hyderabad, India! Fantastic to reconnect with friends & colleagues, dive into top-notch science (gut feeling included 😉), and be inspired by brilliant students & postdocs. Great talks, great food, what a blast! 🔥👏 #TBScience #MicroSky

16 2 1 1