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City University Research Sheds Light on 'Asian Flush' Mechanism for Heart Attack Treatments CityUHK researchers reveal the genetic basis of 'Asian Flush', linking it to severe heart damage and pioneering new treatment avenues for heart attacks.

City University Research Sheds Light on 'Asian Flush' Mechanism for Heart Attack Treatments #Hong_Kong #HEART_ATTACK #Asian_Flush #ALDH2

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This study highlights #ALDH2 inhibition as a potent synthetic lethal strategy for APC-deficient #ColorectalCancer, inducing tumor cell death through the ROS-dependent activation of the ASK1/JNK apoptotic pathway.

#OpenAccess: doi.org/10.1016/j.ge...

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New publication alert πŸ“’

This new review explores how alcohol, genetics, aging, immunity, and the gut microbiome converge to shape disease risk across the lifespan.

Read the research: πŸ”— zurl.co/AIrI4

#AlcoholResearch #GutMicrobiome #BrainHealth #IntegrativeHealth #ALDH2 #PublicHealth

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Unlike alcohol which is metabolized to acetaldehyde within the body, you can also inhale aldehydes. One source of inhaled aldehydes is e-cigarettes and tobacco cigarettes. #aldehydes #ALDH2 #ecigarettes

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If you #flush when drinking alcohol, you may have the #ALDH2 variant.

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This #TopicalReview by Katia S. G. Andrade et al. examines targeting #ALDH2 to promote skeletal muscle health as a novel strategy against #mitochondrial dysfunction πŸ’‰ πŸ”Ž

πŸ”— Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Because not much is known about endometriosis, we tested the hypothesis that reactive aldehydes and reactive aldehyde accumulation underlies the painful condition of endometriosis.

#Pain #Endometriosis #ALDH2
@ericgross.bsky.social

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Despite affecting ~176 million women worldwide, endometriosis screening, detection, and treatment has made little progress.

Many available treatments cause unwanted side effects and are at times ineffective.
#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social

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1 in 10 women are affected by endometriosis in their life.
This week, we’re talking about Gross lab research endometriosis and endometriosis-associated pain.

#Endometriosis #StanfordAnesthesia #ALDH2
@ericgross.bsky.social

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Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.

▢️ onlinelibrary.wiley.com/doi/10.1111/...

@uob-ieu.bsky.social @bristoluni.bsky.social

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www.popsci.com/science/is-a...

Genetics is important! Carriers of a variant in the alcohol metabolism pathway known as ALDH2*2 causes an accumulation of acetaldehyde which is a known carcinogen. Risk of cancer is higher for carriers of this variant. #dryjanuary #alcohol #Aldh2

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As part of #dryjanuary ,
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2

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Redirecting

research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
doi.org/10.1016/j.bb...

#ALDH2 #TRPV1 #TRPchannels #mitochondria #ToRead

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The Aldehyde Hypothesis
The Aldehyde Hypothesis Heran Darwin is a Professor of Microbiology at NYU School of Medicine, where she has been since 2004. Her research contributions include the characterization...

The Aldehyde Hypothesis | Heran Darwin
youtu.be/zLkq6a_W1nE?...
uploaded today

#ALDH2 #NitricOxide #Immunology #malondialdehyde #methylgyoxal #metabolism #WarburgEffect #Immunometabolism

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