#ARG1

Cosmic Meta IO

@cosmicmeta.io

5 months ago

Trump Wades Into Bailout Politics in Offering a Lifeline to Argentina A $20 billion loan to support Argentina’s president, Javier Milei, could come with economic and political risks.. @cosmicmeta.ai #Arg1

https://u2m.io/HrveFWTj

Rene Sugar

@renesugar.bsky.social

8 months ago

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients #ARG1 #MECFS #LongCovid

bsky.app/profile/rene...

Rene Sugar

@renesugar.bsky.social

8 months ago

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients - PubMed Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-...

pubmed.ncbi.nlm.nih.gov/23454751/

"Finally, rescue of arginase-I activity after STAT3 blockade restored MDSC’s suppressive function." #ARG1

Rene Sugar

@renesugar.bsky.social

8 months ago

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients - PubMed Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-...

pubmed.ncbi.nlm.nih.gov/23454751/

"Inhibition of STAT3 signaling also resulted in decreased arginase-I activity." #ARG1

Rene Sugar

@renesugar.bsky.social

8 months ago

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients - PubMed Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-...

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients #ARG1 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/23454751/

Rene Sugar

@renesugar.bsky.social

1 year ago

L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes - PubMed Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction. T...

L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes #citrulline #ARG1 #ARG2 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/33414716/

Rene Sugar

@renesugar.bsky.social

1 year ago

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? #ARG1 #ARG2 #MECFS #LongCovid

bsky.app/profile/rene...

Rene Sugar

@renesugar.bsky.social

1 year ago

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart Key points Exposure to environmental hypoxia, at high altitude or in a chamber, impairs cardiac energetics and alters mitochondrial function. Inorganic nitrate, a ubiquitous dietary constituent, im.....

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart #ARG1 #ARG2 #MECFS #LongCovid

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Rene Sugar

@renesugar.bsky.social

1 year ago

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? #ARG1 #ARG2 #MECFS #LongCovid

academic.oup.com/cardiovascre...

Rene Sugar

@renesugar.bsky.social

1 year ago

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."

"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."

Rene Sugar

@renesugar.bsky.social

1 year ago

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...