#CD39

Molecular Biomedicine

@mol-biomed.bsky.social

4 months ago

CD39 and CD73: biological functions, diseases and therapy - Molecular Biomedicine Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosph...

#Review
#CD39 and #CD73: biological functions, diseases and therapy doi.org/10.1186/s435...

#Adenosine #Function #Disease #Therapy

Second Ave. Sagas

@2avesag.as

9 months ago

This is #cd39. I can’t edit this typo.

bsky.app/profile/2ave...

JMCC Plus

@jmccplus.bsky.social

11 months ago

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model.

Read more: www.sciencedirect.com/science/arti...

Edelblum Lab

@edelblumlab.bsky.social

11 months ago

📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social

Edelblum Lab

@edelblumlab.bsky.social

11 months ago

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

Check out our new #preprint to learn how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype 🤩

Edelblum Lab

@edelblumlab.bsky.social

11 months ago

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

Prof John Gordon

@profcelentyx.bsky.social

1 year ago

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39 This research shows that Th1 cells convert into T-bet+ pTreg cells in response to TGF-β signaling in the TME. Tan et al. demonstrate that T-bet is essentia

@jem.org breaking study!

Major #Tregs #TME #CD39 insights offer new approaches to #Immunotherapy targeting #Cancers