#gdTcells

γδ T cell Forum

@forum-gd.bsky.social

1 day ago

Dual faces of γδ T cells in trypanosomatid infections In this review, we tell the story of how two related parasites that belong to the same genus, Trypanosoma brucei and Trypanosoma cruzi, cause very dis…

Dual faces of γδ T cells in trypanosomatid infections

#gdTcells @cp-trendsparasitol.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 week ago

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 week ago

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model

#gdTcells @coffeltlab.bsky.social

Payal Yokota

@payalyokota.bsky.social

2 weeks ago

So great to see this out in print! Congratulations to Yue and @drshrutinaik.bsky.social team on this fantastic story! 🎉 #GDTcells

γδ T cell Forum

@forum-gd.bsky.social

2 weeks ago

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and ...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight

#gdTcells @bsilvasantos.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

2 weeks ago

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection TCRγδ+ intraepithelial lymphocytes (γδIELs) are crucial for maintaining intestinal homeostasis, yet their functional regulation remains incompletely u…

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

#gdTcells @cp-immunity.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

2 weeks ago

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

#gdTcells @nature.com

David Davies-Payne

@d2p.bsky.social

2 weeks ago

Frontiers | Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Lon... IntroductionThe cellular mechanisms underlying Long COVID (LC) associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain poorly unde...

"… revealing widespread transcriptional remodeling across both innate and adaptive immune compartments."

"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."

#MECFS #LongCovid #GDTcells

www.frontiersin.org/journals/imm...

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases The immune microenvironment of the male genitourinary tract is orchestrated by immune cells including unconventional T cells, which mainly consist of γδ T cells, natural killer T (NKT) cells, and muc...

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases

#gdTcells

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function The human TCRγδ constant region modulates T cell activation and corresponds with T cell clonal expansion and function.

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function

#gdTcells @sciimmunology.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Structural biology of γδ T cell receptors T cell receptor (TCR) diversity underpins cellular immunity. While αβ TCRs have been extensively studied in the context of major histocompatibility co…

Structural biology of γδ T cell receptors

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γδ T cell Forum

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1 month ago

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy In this opinion article, Silva-Santos et al. discuss the potential of Vδ1+ γδ T cells for cancer immunotherapy, focusing on DOT cells. These in vitro–expan

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

#gdTcells @jem.org

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

#gdTcells @natcomms.nature.com

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Ex vivo expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal

#gdTcells @insight.jci.org

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response.

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis

#gdTcells @sciimmunology.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells Author summary Malaria remains one of the deadliest infectious diseases, disproportionately affecting young children in sub-Saharan Africa who succumb to sequelae of Plasmodium falciparum infection. H...

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells

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γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Happy Sunday!

ICYMI #GDTcells

www.frontiersin.org/journals/imm...

www.sciencedirect.com/science/chap...

link.springer.com/article/10.1...

onlinelibrary.wiley.com/doi/10.1111/...

www.sciencedirect.com/science/chap...

www.sciencedirect.com/science/chap...

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

γδ T cell-derived IL-4 initiates CD8+ T cell immunity

#gdTcells @natimmunol.nature.com

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia Key Points. The vast majority of TCRγδ+ T-ALLs express homeodomain-containing (HD+) oncogenes and display features of pre-αβ cortical thymocytes.Overexpres

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia

#gdTcells @bloodjournals.hematology.org

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in... While regulatory T cells (Tregs) control autoimmune diseases (AID), the role of evolutionarily older Foxp3+ γδTregs is much less understood. We noted that both lesional and non-lesional skin of patien...

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo

#gdTcells

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity Commensals shape host physiology through molecular crosstalk with host receptors. Identifying specific microbial factors that causally influence host …

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity

#gdTcells @cp-immunity.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

1 month ago

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma Background Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various can...

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma

#gdTcells @sitcancer.bsky.social

γδ T cell Forum

@forum-gd.bsky.social

2 months ago

Never underestimate the power and the wits of minor immune cell populations.

Come and join us in Wroclaw for next year's #gdTcells #gd2027 conference.

Edelblum Lab

@edelblumlab.bsky.social

2 months ago

#gd2027 is in Wrocław, Poland. Is this a gd17 🦌vs gdIFN 🦏 matchup? #gdTcells @forum-gd.bsky.social

@lydialynch.bsky.social @neilemccarthy.bsky.social @payalyokota.bsky.social @coffeltlab.bsky.social @ph-papotto.bsky.social @gold-efisch.bsky.social

Payal Yokota

@payalyokota.bsky.social

2 months ago

awesome new review from @edelblumlab.bsky.social about #GDTcells in IBD. Like Karen said, we hope to see many more of you in Wrocław for the #GDT2027 / Poland.

👇

Edelblum Lab

@edelblumlab.bsky.social

2 months ago

Moral of the story: If your data take you to the magical land of #gdTcells and you're not an expert, reach out to a #gdTcell afficionado. We're a pretty friendly bunch with a great monthly #gdTcellclub webinar + biannual meeting (Poland 2027!). Find us here: @forum-gd.bsky.social

/✌️2025

Edelblum Lab

@edelblumlab.bsky.social

2 months ago

While there remains a lot to be learned about the respective roles for #gd17 and #gdIFN LPLs in intestinal inflammation, we explain why it's important not to lump all #gdTcells together. There's a learning curve to working with #unconventionalTcells, but the tools and knowledge exist 4/n

Edelblum Lab

@edelblumlab.bsky.social

2 months ago

This is particularly important to consider when investigating the role of the microbiota in #IBD. Historically, a gdTcell-deficient mice have been used in experimental colitis models to show that commensals have an effect on #gdTcells and vice versa. 2/n

γδ T cell Forum

@forum-gd.bsky.social

2 months ago

Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD

#gdTcells @edelblumlab.bsky.social