#CD47

MedComm

@medcomm.bsky.social

2 months ago

Efferocytosis in Health and Disease Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints bal...

#Review in #MedComm
Efferocytosis in Health and Disease doi.org/10.1002/mco2...

#ApoptoticCellClearance #CD47 #TAMreceptor #efferocytosis #ImmunometabolicRewiring

Molecular Biomedicine

@mol-biomed.bsky.social

2 months ago

Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera - Molecular Biomedicine Tumor-infiltrating regulatory T (Treg) cells contribute to immune evasion and are associated with poor prognosis in solid tumors. While CD47 blockade has demonstrated efficacy in hematologic malignanc...

#Research
Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera doi.org/10.1186/s435...

#RegulatoryTcells #CD47 #PD_L1 #Immunotherapy #TME #AptamersiRNAchimera

@healthdivine.bsky.social

8 months ago

🛡️ Don’t eat me! CD47 therapies are unlocking a new era in cancer immunotherapy. 🧠🧫
#CD47 #CancerTreatment #Immunotherapy #TargetedTherapy #Oncology 🧬

www.marketresearchfuture.com/reports/cd47...

@newswise.bsky.social

11 months ago

Neuroscientists Unveil Digital 'Translator' for Brain Studies | Newswise UCLA Health researchers have helped to develop a new digital toolbox to create a “common language” for brain network studies, potentially accelerating new discoveries and treatments for neurological a...

Neuroscientists Unveil Digital 'Translator' for Brain Studies
www.newswise.com/articles/neu...
#CD47 #mesenchymal #fracturerepair #bonefracture #inflammation #translator #studies

TranSpread

@transpread.bsky.social

11 months ago

Published on March 3, 2025, in Bone Research, a study found that mice lacking CD47 exhibited delayed callus formation and significantly lower bone volume compared to their wild-type counterparts.
#CD47 #fracturerepair
Details: doi.org/10.1038/s41413-025-00409-0

Rene Sugar

@renesugar.bsky.social

1 year ago

CD47-targeted immunotherapy unleashes antitumour immunity in Epstein-Barr virus-associated gastric cancer The aims of this study were to enhance the antitumour immunity in Epstein-Barr virus-associated gastric cancer (EBVaGC). We performed RNA-seq analysis…

CD47-targeted immunotherapy unleashes antitumour immunity in Epstein-Barr virus-associated gastric cancer #EBV #CD47 #SIRPα

www.sciencedirect.com/science/arti...

Rene Sugar

@renesugar.bsky.social

1 year ago

www.cell.com/cell-reports...

"There is also evidence that #CD47 - #SIRPα interactions are important contributors to the maintenance of peripheral tolerance via STAT3 activation (Toledano et al., 2013)."

Rene Sugar

@renesugar.bsky.social

1 year ago

Metformin mediates induction of miR‐708 to inhibit self‐renewal and chemoresistance of breast cancer stem cells through targeting CD47 Breast cancer stem cells (BCSCs) have been considered responsible for cancer progression, recurrence, metastasis and drug resistance. However, the mechanisms by which cells acquire self‐renewal and ch...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"The main mechanism of #CD47 ‐mediated immune escape is that it can interact with signal regulatory protein‐alpha ( #SIRPα ) on the surface of macrophages to ultimately blocking phagocytosis."

David Finlay

@davidfinlaytcd.bsky.social

1 year ago

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma

#GBM #Lactate #CD47 #HistoneLactylation

JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

Vigeo Therapeutics

@vigeotx.bsky.social

2 years ago

So proud of the @vigeotx.bsky.social Team on the publication of our First in Human Phase 1 study with VT1021 in #NatureCommunicationsMedicine This paper is a great achievement showing the power of VT1021 treating solid tumors #CD36 #CD47 #VT1021 #NaturePortfolio
rdcu.be/dvUw8