#MedComm

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1 month ago

Something Went Wrong Anthropic joins OpenAI's push into health care with new Claude tools

Anthropic and OpenAI are pushing into healthcare. Google just pulled AI Overviews for some medical queries after accuracy concerns. The opportunity is real, but so is the risk.

www.nbcnews.com/tech/tech-ne...

#AIinHealthcare #Claude #MedComm

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MedComm

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1 month ago

LungSurg: A Generative AI System for Segmentation and Phase Classification in Thoracoscopic Lobectomy The study introduces LungSurg, an AI system designed to assist in video-assisted thoracoscopic (VATS) lobectomy for lung cancer by accurately identifying anatomical structures and surgical phases. Th...

#Article in #MedComm
#LungSurg: A Generative #AI System for Segmentation and Phase #Classification in #ThoracoscopicLobectomy
doi.org/10.1002/mco2...

#DeepLearning #lobectomy #ThoracicSurgery #SurgicalEducation

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MedComm

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1 month ago

The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression Healthy dietary patterns are associated with gut microbial genera linked to lower depressive symptoms. In 644 older adults from the PREDIMED-Plus cohort, 16S rRNA sequencing and dietary scoring revea....

#Article in #MedComm
Prof. Jordi Salas-Salvadó @JordiSalasSalva and his group revealed The #GutMicrobiota as a Mediator in the Relationship Between #Dietary Patterns and #Depression doi.org/10.1002/mco2...

#MediterraneanDiet #MicrobiomeMediation #MentalHealth #sequencing

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MedComm

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1 month ago

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome-targeted intervention strategies can improve ....

#Review in #MedComm
Tumor Immunotherapy and Microbiome: From Bench-to-Bedside Applications doi.org/10.1002/mco2...

#Review #ICIs #Immunotherapy #microbiome #TumorMicroenvironment #TME #FMT

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MedComm

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1 month ago

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreti...

#Review in #MedComm
Peripheral Nerves in #Cancer: Regulatory Roles and #Therapeutic Strategies doi.org/10.1002/mco2...

The review provides comprehensive insight into the interaction between #nerves and cancer cells, paving way for neuron-signaling-based anticancer therapies.

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MedComm

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1 month ago

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL-6-pSTAT3Tyr705-stemness axis. VEM is a potential candidate drug fo...

#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway

doi.org/10.1002/mco2...

#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3

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MedComm

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1 month ago

Noninvasive Early Detection and Recurrence Monitoring for Non‐Muscle‐Invasive Bladder Cancer via Urine Tumor DNA: A Prospective Clinical Study In NMIBC surveillance, positive postoperative utLIFE-UC results before initial follow-up cystoscopy were significantly associated with increased relapse risk. Longitudinal analysis showed that positi...

#Article in #MedComm
#Noninvasive Early Detection and Recurrence Monitoring for Non-Muscle-Invasive Bladder Cancer (#NMIBC) via Urine Tumor DNA: A #Prospective #Clinical Study doi.org/10.1002/mco2...

#EarlyDetection #UrineTumorDNA #RecurrenceMonitoring

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MedComm

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1 month ago

Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia Treadmill training protects against white matter injury and reduces cerebral infarction. Muscle-derived mitochondrial transfer via platelets is promoted by treadmill training. Platelet transfusion em...

#Article in #MedComm
#Mitochondrial Intercellular Transfer via #Platelets After Physical Training Exerts Neuro-Glial Protection Against Cerebral Ischemia doi.org/10.1002/mco2...

Studied by a team from Juntendo University
#CerebralInfarction #PlateletTherapy #stroke

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MedComm

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1 month ago

#Article in #MedComm
Low Dose of #IL_2 Application for Graft-Versus-Host Disease (#GVHD) Prophylaxis Following Haploidentical Stem Cell Transplantation doi.org/10.1002/mco2...

#Tregs #interleukin_2 #NKcell

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MedComm

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1 month ago

Regulation and Mechanism of Deleted in Breast Cancer‐1 on Dendritic Cell Function in Systemic Lupus Erythematosus LPS-stimulated DC activation upregulated DBC1. DBC1-deficient DC ameliorated murine SLE symptoms. DBC1 deficiency suppressed immune responses in DC. DBC1 deficiency lowered STAT5 expression and subse...

#Article in #MedComm
Regulation and Mechanism of Deleted in Breast Cancer-1 (#DBC1) on Dendritic Cell Function in Systemic Lupus Erythematosus (#SLE)
doi.org/10.1002/mco2...

#AutoimmuneDisease #DendriticCell #STAT5 #Tfh

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MedComm

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1 month ago

#Review in #MedComm
#Wnt Signaling #Pathway: Biological Function, Diseases, and #Therapeutic Interventions doi.org/10.1002/mco2...

The review outlines its components, functions, regulators, and preclinical models, highlighting #SFRPs as context-dependent, biphasic modulators.

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MedComm

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1 month ago

N6‐Methyladenosine Modification of circIST1 Promotes Hypoxia‐Inducible Factor α–mediated Glycolysis and Progression in Hepatocellular Carcinoma We identified first time a critical m6A modification of circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into...

#Article in #MedComm
This article identified first time a critical #m6A modification of #circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the #HCC progression and #tumor #glycolysis. doi.org/10.1002/mco2...

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MedComm

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1 month ago

Landscape of Somatic and Age‐Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long‐Read Sequencing This study leveraged long-read sequencing (LRS) to provide a comprehensive analysis of structural variations (SVs) in the human hepatocellular carcinoma (HCC) genome. Somatic SVs were found to be mor...

#Article in #MedComm
Landscape of #Somatic and #Age-Related Pathogenic Structural Variations in Hepatocellular Carcinoma (#HCC) Revealed by Long-Read #Sequencing doi.org/10.1002/mco2...

#HBV #HepatocellularCarcinoma #C1orf #DPRX

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MedComm

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1 month ago

#Article in #MedComm
#Obestatin Treatment Counteracts #Muscle Wasting by Reactivation of #Autophagy in Duchenne Muscular Dystrophy (#DMD), studied by a research team from Complejo Hospitalario Universitario De Santiag
doi.org/10.1002/mco2...

#mTORC1 #AMPK #ULK1 #NEDD4 #VPS34

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MedComm

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1 month ago

Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation This study demonstrates that emestrin-type ETPs suppress GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis....

#Article in #MedComm
Emestrin-Type Epidithiodiketopiperazines (#ETPs) Inhibited Gasdermin D-Mediated #Pyroptosis via #Caspase-3/7 Activation doi.org/10.1002/mco2...

#gasderminD #GSDMD #sepsis

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MedComm

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1 month ago

#Article in #MedComm
Characterization of #Korean Colorectal Cancer (#CRC) Reveals Novel Driver Gene and Clinically #Relevant #Mutations
doi.org/10.1002/mco2...

#ColorectalCancer #microsatellite #instability #mutational #hotspot #tumor #mutational #sequencing

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MedComm

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2 months ago

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell‐Derived Extracellular Vesicles in Rheumatoid Arthritis CCR2 orchestrates preferential homing of GMSC-derived extracellularvesicles to inflamed joints in rheumatoid arthritis.

#Article in #MedComm
#CCR2 Orchestrates Preferential #Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell-Derived Extracellular #Vesicles in Rheumatoid Arthritis doi.org/10.1002/mco2...

#chemotaxis #RheumatoidArthritis #RA #GMSCs #inflammation

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MedComm

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2 months ago

#Review in #MedComm
#Organoids in #Cancer Research and #Regenerative Medicine: Current Status, Challenges, and Future Prospects doi.org/10.1002/mco2...

#DiseaseModeling #DrugScreening

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MedComm

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2 months ago

#Review in #MedComm
Mastering #Organoid Growth: A Complete #Guide to Overcoming Methodological Challenges doi.org/10.1002/mco2...

#cholangiocyte #methodology #organoid #Applications

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MedComm

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2 months ago

#Article in #MedComm
Longitudinal Analysis of Male Fertility Using an Acr-Luc Knock-In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing doi.org/10.1002/mco2...

#BioluminescenceImaging #MaleFertility #RReproductiveToxicity #Spermatogenesis

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MedComm

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2 months ago

#Review in #MedComm
#Melanoma: Pathogenesis and Targeted Therapy doi.org/10.1002/mco2...

This review summarizes the molecular classification of melanoma, synthesizes current therapeutic approaches, and highlights persistent clinical challenges.
#NRAS #BRAF #immunotherapy

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MedComm

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2 months ago

Sepsis Endotypes Defined by Lymphocyte Thresholds and Inflammation Inform Precision Immunomodulation Sepsis outcomes are shaped by immune–inflammatory imbalance. Integrative profiling identified critical lymphocyte thresholds and defined endotypes linking immune depletion with inflammation. Patients...

#Article in #MedComm
Sepsis Endotypes Defined by #Lymphocyte Thresholds and #Inflammation Inform #Precision Immunomodulation doi.org/10.1002/mco2...

Patients with low inflammation but lymphocyte loss benefited from corticosteroids, while hyperinflammatory endotypes did not.

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MedComm

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2 months ago

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Furthe...

#Article in #MedComm
#Spatial Transcriptional #Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury doi.org/10.1002/mco2...

#MIR #Piezo1 #SingleCell #RNA #sequencing

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MedComm

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2 months ago

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutic...

#Review in #MedComm
#Monkeypox #Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics doi.org/10.1002/mco2...

#diagnosis #epidemiology #therapeutics #virology #vaccine

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MedComm

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2 months ago

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. I...

#Article in #MedComm

Ramalin Ameliorates #Alzheimer's Disease Pathology by Targeting #BACE1, #HDAC6, and #MAPK Pathways doi.org/10.1002/mco2...

#Ramalin restores synaptic function impaired by #Aβ toxicity and improves cognitive performance in #AD mouse models.

#NLRP3

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MedComm

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2 months ago

#Highlight in #MedComm
DNA Circuits That Learn: Biochemical Signal Processing for Personalized #Diagnosis and #Treatment doi.org/10.1002/mco2...

The highlighted article in @nature.com : doi.org/10.1038/s415...

#DNAcomputing #SyntheticBiology

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MedComm

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2 months ago

Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through Multi‐Omics and Mendelian Randomization Analysis We performed UPLC-MS/MS lipidomics and DIA proteomics on plasma from healthy controls, active TB patients, and cured patients, and used Mendelian randomization to prioritize diagnostic and cure bioma...

#Article in #MedComm
Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through #Multi_Omics and Mendelian Randomization Analysis doi.org/10.1002/mco2...

This article proposed #haptoglobin (HP) as a promising #biomarker and potential #TherapeuticTarget.

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MedComm

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2 months ago

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the T...

#Review in #MedComm
The Role of #Macrophages in #Cancer: From Basic Research to Clinical Applications doi.org/10.1002/mco2...

This review highlights the translational potential of #TAM-targeted therapies and the value in reshaping the immunosuppressive #TME.

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Fiberopticgal

@fiberopticgal.bsky.social

2 months ago

Public health data should be as available as the weather forecast “Public health data should be just as available and intuitive as a weather app,” Deborah Birx writes.

Public health data should be as available as the weather forecast
Practical, local, community-specific insights can help people make smart decisions

www.statnews.com/2026/01/05/p...

#publichealth #infectiousdisease
#medcomm