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Posts tagged #CD8TCells

Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection.
Dorrestein, Pieter C et al.
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#Metabolomics #CD8TCells #ChronicInfection

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Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy.
Chen, Xu et al.
Paper
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#Immunotherapy #CD8Tcells #ExerciseScience

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🔬 First head-to-head comparison of nuclear imaging for tumour CD8⁺ T cells shows [⁸⁹Zr]Zr-anti-CD8-IgG2a(silent) & [⁸⁹Zr]Zr-OT-I track T-cell infiltration & migration, aiding immunotherapy strategies.

👉 https://bit.ly/4ncWCzv

#Immunotherapy #CD8Tcells #CancerResearch

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This is an interesting study looking at different nuclear imaging methods to determine which best reflects T cell infiltration

@imtadvances.bsky.social
#immunotherspy #CD8TCells

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Tracking CD8+ T cells in tumours is key for immunotherapy research. Our new study compares nuclear imaging methods to see which best reflects T cell infiltration.

🔗 Open access: https://bit.ly/4ncWCzv

#Immunotherapy #CD8TCells #CancerResearch

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Synapse: Your Connection to our MSK Authors
Meet: Anna Mary Varghese @AnnaVarghese4

Research Focus: Medicine; Associate Attending

synapse.mskcc.org/synapse/work...

#PancreaticCancer #Immunotherapy #CancerVaccine #Neoantigen #RNAVaccine #CD8TCells #CancerResearch #BreakthroughScience

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Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...

New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8⁺ T cell apoptosis via calcium overload—offering a novel strategy to treat type IV hypersensitivity
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...

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Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype AbstractImmune checkpoint blockade (ICB) has revolutionized cancer treatment. Unfortunately, the inability of lymphocytes to infiltrate the tumor nest, a phenomenon known as immune exclusion, drastica...

🆕 Our back-to-back papers reveal a surprising villain in ICB resistance: NK cells.

🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.

#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells

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5/16
Age primarily affected #Tcells in #CSF and blood, which became activated with age. Interestingly, #CD8Tcells increased in #CSF with age but decreased in blood, suggesting that age-related changes are partially compartment-specific.

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Cancer as a city with different neighbourhoods: #spatial profiling helps us identify the cells as apartments, and look inside for their activities -Great talk by @bottomleymatt.bsky.social from @uniofoxford.bsky.social
#BSIWinterSchool24
@britsocimm.bsky.social
#CD8Tcells #senescence #ImmunoSky

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New pre-print out from
Rusty Jones’ team:
Dietary restriction enhances CD8+T cell metabolic fitness via increased ketolysis ->boosts mitochondrial membrane potential ->fuels TCA cycle-dependent pathways —>more effective CD8 effectors in TME
#immunosky #immunometabolism #CD8Tcells
#cancermetabolism

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People infected with #SarsCoV2 🦠 that cleared the virus more quickly if they had high levels of #cd8tcells and mucosal IgA. This suggests that #COVID19vaccines that optimally induce these responses may help reduce transmission.

www.science.org/doi/pdf/10.1...

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Celebrating great success of #AcademiaICRC student!! @klara_mensikova won🥈with talk on #CD8Tcells & #immunosenescence in the Theoretical and preclinical research section at 66th Student Scientific Conference @Science_MEDMUNI ! Project led by @LaznickovaPetra @FricLab @FNUSA_ICRC

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