Weisman, Caroline M., Andrew W. Murray, and Sean R. Eddy. “Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes.” Current Biology 0, no. 0 (May 18, 2022). https://doi.org/10.1016/j.cub.2022.04.085.
Weisman, Caroline M., Andrew W. Murray, and Sean R. Eddy. “Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes.” Current Biology 0, no. 0 (May 18, 2022). https://doi.org/10.1016/j.cub.2022.04.085.
False positive rates in studies of gene birth/death dynamics are documented to be exceptionally high. If you just pull primary transcripts for 100 species & chuck it into CAFE pipeline, you're likely grossly overestimating lineage specific dyanmics #genomics #comparativegenomics #evolution