#GenomeScience

IMPRS for Genome Science

@imprsgs.bsky.social

2 months ago

🚨 Last call - deadline extended to Jan. 15! PhD positions at the Max Planck Institute & University of Göttingen! #IMPRSGS #GönomiX
➡️ www.uni-goettingen.de/de/applicati...
#PhD #GenomeScience #Bioinformatics #ComputationalBiology #Germany @mpi-nat.bsky.social @uni-goettingen.de

IMPRS for Genome Science

@imprsgs.bsky.social

3 months ago

Doctoral hat surrounded by icons representing genome science fields: math, bioimaging, genomics, bioinformatics & more. Logos for Uni Göttingen, GönomiX & IMPRS-GS.

Want to shape the future of genome science? 🧬 PhD positions available at Max Planck Institute & Uni Göttingen (IMPRS-GS/GönomiX)! Join a vibrant, interdisciplinary research community. Apply by Jan 14, 2026: www.uni-goettingen.de/de/applicati... #GenomeScience #Research

Anita Scoones

@anitascoones.bsky.social

8 months ago

Arrived at #GenomeScience! Looking forward to catching up with colleagues, meeting new faces, and discussing all things genomics 🙌. Day 2 (12.05pm, G26) presenting our work using #longreads for #scRNAseq - on biorxiv this week📑- otherwise find me @ poster 3/ @earlhaminst.bsky.social stand 🧬 #gsuk25

Earlham Institute

@earlhaminst.bsky.social

8 months ago

Tom Brabbs using the Tecan Automated Liquid Handling platform in the EI labs. Tom wears a white lab coat and orange safety gloves.

Anita, postdoctoral researcher, sits with PhD student Fran and Group Leader Iain at a desk with open laptops.

Group Leader Chris Quince chatting and smiling with two of his group members at a recent conference.

At #GenomeScience this week? Catch up with the Earlham Institute team presenting talks on:
🦠 #Metagenomics, #microbiomes, and #longread sequencing
🌾 Wheat pan genomics
🧬 Benchmarking long-read #scRNA-Seq Approaches
📚 A new short-read #RNAlibrary preparation kit

www.genomescience.org.uk/speakers/

Anita Scoones

@anitascoones.bsky.social

8 months ago

Looking forward to presenting at #GenomeScience this week! ✨- I'll be discussing our work benchmarking #singlecell #longread approaches, freshly on biorxiv as of this morning! 🧬📄

Earlham Institute

@earlhaminst.bsky.social

8 months ago

Social graphic promoting Earlham Institute attending Genome Science event in Newcastle. Profile photos of 9 people from EI displayed in a grid with their names down the side.

Looking forward to #GenomeScience in Newcastle next week! 🖥️ 🧬

Catch up with the Earlham Institute team who will be presenting talks and posters on topics including:
🦠 #Metagenome-assembled genomes from complex #microbiomes
🌾 Wheat pan genomics
🧬 Benchmarking Long-Read scRNA-Seq Approaches

Earlham Institute

@earlhaminst.bsky.social

8 months ago

We're looking forward to #GenomeScience next month in Newcastle - but be quick, registration closes tomorrow! 🏃‍♀️

Earth BioGenome Project 🌍

@ebpgenome.bsky.social

9 months ago

(2/3) 🌍 By sequencing the genomes of over 240 mammalian species, scientists can identify conserved genes — the ancient, unchanging parts of DNA that reveal what’s truly essential for life. 🧬

#ZoonomiaProject #ComparativeGenomics #Evolution #GenomeScience #Biodiversity #HumanHealth #Conservation

Earlham Institute

@earlhaminst.bsky.social

9 months ago

Research Assistant Daniella Shipley using the Tecan automated liquid handling platform in the EI sequencing labs

We're looking forward to joining #GenomeScience next month at Newcastle University. Scientists from Earlham Institute will be discussing their research in sessions focused on animal, plant, and microbial genomics!

Registration closes 26 June ➡️ buff.ly/rhzuKR4

‪@whatchamacaulay.bsky.social‬

Shicheng Guo

@shihcheng.bsky.social

11 months ago

Structural insights into RNA cleavage by PIWI Argonaute | Nature Argonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression1. By contrast, PIWI-clade proteins predominantly function during gametogenesis to suppress transposons and ensure fertility1,2. Both clades use nucleic acid guides for target recognition by means of base pairing, crucial for initiating target silencing, often through direct cleavage. AGO-clade proteins use a narrow channel to secure a tight guide–target interaction3. By contrast, PIWI proteins feature a wider channel that potentially allows mismatches during pairing, broadening target silencing capability4,5. However, the mechanism of PIWI-mediated target cleavage remains unclear. Here we demonstrate that after target binding, PIWI proteins undergo a conformational change from an ‘open’ state to a ‘locked’ state, facilitating base pairing and enhancing target cleavage efficiency. This transi

"Peek inside PIWI Argonaute's RNA cutting action! 🌟😮 AGOs regulate genes broadly, while PIWIs ensure fertility during gametogenesis. #GenomeScience" PMID:39814893, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08438-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪