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A Tiny Enzyme Flaw May Explain How Dementia Begins Scientists have identified a small flaw in the enzyme GPX4 that prevents neurons from defending themselves. This mutation, found in children with a rare form of early dementia, disrupts a tiny loop the...

A Tiny Enzyme Flaw May Explain How Dementia Begins #Science #HealthandMedicine #Neurology #DementiaResearch #Neuroscience #EnzymeFunction

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Enzymes, geometry, and big data in Liverpool!

@rhackett.bsky.social presented his project at #ISMBECCB2025, showcasing matching of catalytic motifs for enzyme function prediction.

#StructuralBioinformatics #EnzymeFunction #CatalyticMotifs
#ProteinStructure #EMBL #LUMC

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In humans, different isoforms are scattered across the body:
•CA II in red blood cells
•CA IV on kidney membranes
•CA IX/XII in tumors
•CA VA/VB in mitochondria
Each one fine-tuned for specific roles.
#HumanBiology #EnzymeFunction

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