#ProteinStructure

@kill-bait.bsky.social

2 days ago

Structural Changes in Blood Proteins Could Enable Early Detection of Alzheimer’s Disease Researchers at Scripps Research Institute have developed a novel blood test that may detect Alzheimer’s disease earlier than current methods by analyzing subtle structural changes in proteins rather than their levels. The study, involving over 500 participants, found that three proteins in the blood—C1QA, clusterin, and apolipoprotein B—showed structural changes that strongly correlate with Alzheimer’s progression. Using mass spectrometry and machine learning, the team was able to differentiate cognitively normal individuals from those with mild cognitive impairment or Alzheimer’s with high accuracy, exceeding 93% in some comparisons. These findings suggest that monitoring protein folding disruptions in the blood could serve as a predictive biomarker, complementing traditional amyloid beta and tau tests. Repeat tests confirmed the reliability of this protein structural score over time and its correlation with cognitive performance and, to a lesser degree, brain shrinkage seen on MRI scans. While the research is promising, larger studies with longer follow-up periods are necessary before clinical application. The approach could eventually help diagnose Alzheimer’s at an earlier stage, track disease progression, and evaluate treatment effectiveness. Researchers are also exploring whether similar structural profiling could apply to other diseases such as Parkinson’s and cancer.

Structural Changes in Blood Proteins Could Enable Early Detection of Alzheimer’s Disease

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#alzheimers #bloodtest #proteinstructure

View full AI summary:

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Conny WH Yu

@connyyu.bsky.social

6 days ago

GitHub - connyyu/pymol_sifts: Automatic protein labelling in PyMOL Automatic protein labelling in PyMOL. Contribute to connyyu/pymol_sifts development by creating an account on GitHub.

𝗚𝗶𝘁𝗛𝘂𝗯 𝗹𝗶𝗻𝗸: github.com/connyyu/pymo...
𝗠𝗼𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝗦𝗜𝗙𝗧𝗦: www.ebi.ac.uk/pdbe/docs/si...

#ProteinStructure #StructuralBiology #PyMOL #Bioinformatics #ComputationalBiology

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Tanzeel

@tanzeel-a.bsky.social

3 weeks ago

Weekending using shaders from @blenderkit.bsky.social
Concept inspired by @bradyajohnston.bsky.social
Dynein arms — the ATP-powered engines behind ciliary motion.
#Dynein #Cilia #Axoneme #MolecularBiology #StructuralBiology #CryoEM #ProteinStructure #Biophysics #Blender3D #SciArt #BioArt

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Journal of General Physiology

@jgp.org

3 weeks ago

#MolecularDynamics analyses of CLDN15 pore size and charge selectivity. New study from Sarah McGuinness, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber and colleagues (University of Chicago): rupress.org/jgp/article/...

#MembraneTransport #Biophysics #ProteinStructure #ProteinDynamics

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CRISTOFER SANTIAGO

@echoexplorers91.bsky.social

3 weeks ago

Wgu C785 Final Exam Study Guide Amino Acids Protein Structure 2024 2025 Edition
#Wgu #C785 #WguC785 #AminoAcids #nursing #ProteinStructure #wgu2026 #wguquestionsandanswers #hackedexams

www.hackedexams.com/item/62419/w...

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@science-lane.bsky.social

2 months ago

Happy New Year 2026! 🎆
Peace, Joy & Discovery in 2026! 🌿🔬

#happynewyear2026 #newyear2026 #ramachandranplot #proteinstructure #biophysicss #ComputationalChemistry #structuralbiology #scienceart #scicomm #sciencelane

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Genes & Development

@genesdev.bsky.social

2 months ago

⏪ G&D RECAP ⏪

🗓️ October 2025
RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup & HMGN nucleosome-binding motif
By Alegrio-Louro et al. and Andres Leschziner
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full

#proteininteractions #proteinstructure #cryoEM

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Journal of General Physiology

@jgp.org

2 months ago

A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...

#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels

3 2 0 0

Journal of General Physiology

@jgp.org

2 months ago

Exploring voltage-gated sodium channel conformations and protein-protein interactions using #AlphaFold2. New study from Diego Lopez-Mateos, Kush Narang, & Vladimir Yarov-Yarovoy (@vyy-sf.bsky.social) @ucd-physiology.bsky.social: rupress.org/jgp/article/...

#ProteinStructure #Biophysics #IonChannels

4 1 0 0

Pure Science

@purescience.news

2 months ago

AlphaFold Changed Science. After 5 Years, It’s Still Evolving WIRED spoke with DeepMind’s Pushmeet Kohli about the recent past—and promising future—of the Nobel Prize-winning research project that changed biology and chemistry forever.

AlphaFold Changed Science. After 5 Years, It’s Still Evolving #Science #Biology #MolecularBiology #AlphaFold #ProteinStructure #Biotechnology

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@techlife-blog.bsky.social

2 months ago

AI Transforms Scientific Discovery: How AlphaFold and AI Co-Scientist Are Reshaping Research From solving the 50-year protein folding problem to generating research hypotheses in hours, AI tools like AlphaFold and Google's AI Co-Scientist are compressing discovery timelines from years to days

AI Transforms Scientific Discovery: How AlphaFold and AI Co-Scientist Are Reshaping Research

techlife.blog/posts/ai-tra...

#AlphaFold #Google #DeepMind #ScientificDiscovery #ProteinStructure #Gemini #NobelPrize #AIResearch #AlphaEvolve #BioNeMo #AI

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CAMEO-3D

@cameo3d.org

2 months ago

🚀 New paper in @natmethods.nature.com!
We present OpenStructure's powerful scoring capabilities, used to assess predictionsin CAMEO and CASP.
Read the full study here:
🔗 doi.org/10.1038/s415...
#StructuralBiology #Bioinformatics #OpenStructure #CASP #CAMEO #ProteinStructure

5 4 1 0

Journal of General Physiology

@jgp.org

2 months ago

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC. New study from Hridya Valia Madapally, Himanshu Khandelia @khandeliagroup.bsky.social and colleagues @sdu.dk: rupress.org/jgp/article/...

#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics

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Journal of General Physiology

@jgp.org

3 months ago

Novel binding mode for negative allosteric #NMDA receptor modulators, from James Lotti, Rasmus Clausen @ucph.bsky.social, Kasper Hansen and colleagues @umontana.bsky.social: rupress.org/jgp/article/...

#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics

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Exciting Instruments

@ei-science.bsky.social

3 months ago

⏰ What if your experimental workflow went from weeks to minutes? @shenk0128.bsky.social shares how solution-based measurements complement TIRF:

✓ Faster results
✓ Fewer artefacts
✓ No tethering needed
✓ Proteins stay in their native, comfortable state

#singlemolecule #TIRF #proteinstructure

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Bioinformatics Advances

@bioinfoadv.bsky.social

3 months ago

ProCaliper is an open-source #Python library for integrating #proteinstructure data from UniProt and AlphaFold, computing residue-level properties like charge, solvent accessibility, and pKa, and constructing functional and structural distance networks.

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Pablo G. Camara

@camarapg.bsky.social

4 months ago

Exploring the Structural Lexicon of the Proteome via Metric Geometry The three-dimensional structure of proteins is intimately linked to their function, yet establishing comprehensive frameworks for systematically comparing and organizing protein structures across the ...

New preprint from our lab: We investigate how Gromov-Wasserstein couplings can be applied to protein structure alignment and analysis, with fascinating results. Fantatisc work by Elijah Gunther! www.biorxiv.org/content/10.1... #ProteinStructure #MetricGeometry

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Protein Data Bank in Europe (PDBe)

@pdbeurope.bsky.social

4 months ago

PDBe adopts the new DSSP for protein secondary structure annotation | Protein Data Bank in Europe Advanced Search

The new DSSP version 4 uses mmCIF as its primary format and extends secondary structure detection to include left-handed polyproline II (κ) helices, common motifs that contribute to protein folding and stability.

Full announcement: www.ebi.ac.uk/pdbe/news/pd...

#PDBe #DSSP #ProteinStructure

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Pure Science

@purescience.news

5 months ago

The protein structure problem: solving life’s origami The artificial intelligence program AlphaFold is proving to be a gamechanger for biological research, Imma Perfetto reports. This article was originally published in the Cosmos Print Magazine, September...

The protein structure problem: solving life’s origami #Science #Biology #MolecularBiology #ProteinStructure #LifeScience

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UGSF-Glycobiology

@ugsf-lille.bsky.social

5 months ago

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID-related Rounds), which have witnessed the transition to AI-driven predict...

🧬 New paper out from our Computational Molecular Systems Biology team at @UGSF-lille !
Proud to have contributed to the CAPRI 8 challenge

🔗 Read it here: onlinelibrary.wiley.com/doi/10.1002/...

#CAPRI8 #AlphaFold #ProteinStructure #StructuralBiology #AIinBiology #Bioinformatics #UGSF

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QbitPhased

@qbitphased.com

5 months ago

"What if we could unlock the secrets of complex proteins? A hybrid quantum-classical approach predicts 3D structures of large proteins, paving the way for breakthroughs in drug development. How will this change medicine's future? Share your thoughts! #ProteinStructure #QuantumComputing #Heal... LINK

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michael

@proseandpassion.mastodon.social.ap.brid.gy

5 months ago

Original post on mastodon.social

16-Sep-2025
Better understanding of #bitter #taste receptors: An AlphaFold3-based structure study
Researchers use an advanced AI-based prediction model, #AlphaFold 3, to predict the structure of human bitter taste #receptors
https://www.eurekalert.org/news-releases/1098406

#science #humans […]

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Trends in Biochemical Sciences

@cp-trendsbiochem.bsky.social

6 months ago

📝 Online now - the Review "Decoding protein structures with residue interaction networks" from Silvio Tosatto et al.

#RIN #ProteinStructure #ResidueCentrality #Allosterism #ArtificialIntelligence

Read it here: authors.elsevier.com/sd/article/S...

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Journal of General Physiology

@jgp.org

6 months ago

NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...

#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels

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RichardJR

@electricbluesfan.bsky.social

6 months ago

6/12 Critical difference: The same mutations (N236K/Q238L) in wild-type H5N1 don't switch receptor specificity.

Only in B3.13 strain do these mutations enable human receptor binding. The conformational context matters enormously.
#ProteinStructure

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Dimitris Kontopoulos

@dgkontopoulos.ecoevo.social.ap.brid.gy

7 months ago

I am excited to introduce our new @EvolLetters paper that has just come out:

academic.oup.com/evlett/advance-article/d...

🧵1/7

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@arxivlens.bsky.social

7 months ago

Allosteric and Energetic Remodeling by Protein Domain Extensions
Faure, A., Hidalgo-Carcedo, C. et al.
Paper
Details
#ProteinStructure #AllostericRegulation #BiochemistryResearch

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EMBO

@embo.org

7 months ago

AI for protein design In the last 5 years, the scientific community has witnessed the development of several AI-based tools for groundbreaking advances in protein science. These tools have enabled scientists to predict pr…

Learn about #AI tools in #protein #science, including design and engineering, at the EMBO Practical Course "AI for protein design" in Puerto Varas, Chile, 3–9 November 2025

Deadline: 1 August

meetings.embo.org/event/25-ai-...
#EMBOaiProteinDesign #research #training #ProteinStructure #EMBOevents 🧪

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@zellerlab.bsky.social

7 months ago

Enzymes, geometry, and big data in Liverpool!

@rhackett.bsky.social presented his project at #ISMBECCB2025, showcasing matching of catalytic motifs for enzyme function prediction.

#StructuralBioinformatics #EnzymeFunction #CatalyticMotifs
#ProteinStructure #EMBL #LUMC

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Posts tagged #ProteinStructure