Opportunity for beamline scientist (XChem) at Diamond Light Source (Harwell Oxfordshire UK) ref: 11716 | closing: 09-Nov-2025 #MX #StructBiol #FBD #FBLD #FBDD #chemsky 🧪
vacancies.diamond.ac.uk/vacancy/prin...
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#FBLD
Latest posts tagged with #FBLD on Bluesky
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Posts tagged #FBLD
Klose et al (2025) #Electrophilic #fragment screening using native mass spectrometry to identify covalent probes for surface cysteines. Aust J Chem 78 CH25081 #FBD #FBLD #FBDD #MS #ChemBiol #MedChem #cheminformatics #OpenAccess #chemsky 🧪
doi.org/10.1071/CH25...
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Interested in #FBLD or #FBDD for #RNA targets? Then read our newest paper on the discovery of RNA-binding fragments using biolayer interferometry (BLI). doi.org/10.1039/D5MD... #MedChem
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The ring system presents an unusual pharmacophore and this is a most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #FBDD #FBLD #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...
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Practical Fragments post on Erlanson et al (2025 #OpenAccess) Where and how to house big data on small fragments. Nat Commun 16:4179 DOI: 10.1038/s41467-025-59233-z #FBD #FBDD #FBLD #StructBiol #MedChem #cheminformatics #DataScience #chemsky 🧪
practicalfragments.blogspot.com/2025/07/how-...
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Opportunity in fragment-based computational design at Lilly (Bracknell UK) ref: R-86733 #FBD #FBLD #FBDD #cheminformatics #CompChem #UKChemJobs #ChemJobs #chemsky 🧪
careers.lilly.com/us/en/job/R-...
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Identifying ligand-binding pockets in #RNA, computationally and experimentally #FBLD #FBDD #CompChem #cheminformatics #chemsky 🧪
practicalfragments.blogspot.com/2025/06/iden...
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Opportunity in fragment-based design at Lilly (job available in 4 locations | UK: Bracknell | USA: Boston MA, Louisville CO, San Francisco CA) ref: R-86733 #FBD #FBDD #FBLD #CADD #CompChem #cheminformatics #ChemJobs #UKChemJobs #chemsky 🧪
careers.lilly.com/us/en/job/R-...
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The Nature of #LigandEfficiency article on which my talk was based was originally submitted to J Med Chem and I reviewed the reviewers of the initial submission pour encourager les autres #LE #FBD #FBDD #FBLD #DrugDiscovery #DrugDesign #metric #chemsky 🧪
fbdd-lit.blogspot.com/2019/01/revi...
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The Nature of Ligand Efficiency was originally submitted to JMC but the study proved a bit too spicy for two of the reviewers and, for the benefit of the journal’s editors, I reviewed the reviewers #LE #metric #MedChem #cheminformatics #FBDD #FBLD #chemsky 🧪
fbdd-lit.blogspot.com/2019/01/revi...
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Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...
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While widely used in #DrugDiscovery #LE can’t accurately be described as a #metric because perception of efficiency varies with the arbitrary unit used to express affinity or potency (there is no ‘right’ unit) #cheminformatics #MedChem #DrugDesign #FBDD #FBLD #chemsky 🧪
doi.org/10.1186/s133...
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PEARLScreen (Perfect Echo for Advanced Relaxation-based Ligand Screen): A new ligand-detected #NMR method for detecting #fragment hits #FBDD #FBLD #DrugDiscovery #DrugDesign #MedChem #AnalChem #cheminformatics #chemsky 🧪
practicalfragments.blogspot.com/2025/03/fish...
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My friend Jeff Albert recently passed away and this is a good way to remember him #FBDD #FBLD #MedChem #cheminformatics
An Integrated Approach to Fragment-Based Lead Generation:Philosophy, Strategy and Case Studies from AstraZeneca's Drug Discovery Programmes #chemsky 🧪
doi.org/10.2174/1568...
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Some thoughts on hydrogen bond donors in selection of fragments for screening #FBDD #FBLD #DrugDesign #DrugDiscovery #MedChem #cheminformatics #chemsky 🧪
fbdd-lit.blogspot.com/2022/07/hb-d...
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A most excellent molecule with which to conclude the week (great for #SynChem and I'd also include this #oxetane in a fragment library) #MedChem #DrugDiscovery #DrugDesign #FBDD #FBLD #chemsky 🧪
new.enaminestore.com/catalog/EN30...
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Fearon et al (2024) Accelerating #DrugDiscovery With High-Throughput #Crystallographic #Fragment Screening and Structural Enablement. Appl Res e202400192 #FBLD #FBDD #DrugDesign #MedChem #StructBiol #OpenAccess #chemsky 🧪
doi.org/10.1002/appl...
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Opportunity in protein & structural chemistry at MSD (London UK) ref: R312134 | closing: 06-Oct-2024 #StructBiol #biophys #FBDD #FBLD #UKChemJobs #ChemJobs #ScienceJobs #chemsky 🧪
jobs.msd.com/gb/en/job/R3...
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I’m new to Bluesky but keen to catch up with any LibDem or like minded folks.
How about LibDem follow back #FBLD ?
If you can repost that would be great 😊🔶
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Beier et al (2024) Probing Protein–Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. J Med Chem ASAP #NMR #MedChem #FBDD #FBLD #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1021/acs....
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Design, quality and validation of the EU-OPENSCREEN #fragment library poised to a high-throughput screening collection #FBLD #FBDD #MedChem #cheminformatics #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1039/D3MD...
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