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Unlocking the hidden pocket on a billion‑dollar drug target For years, a protein inside our cells has quietly powered billions of dollars' worth of cancer drugs. Now a team of researchers have discovered that this workhorse protein, called cereblon, in additio...

Unlocking the hidden pocket on a billion dollar drug target | #DrugDiscovery #chemsky #TPD #CRBN

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Join us at the 6th TPD & Induced Proximity Summit Europe and Induced Proximity Summit in London, 10 to 12 March 2026, which brings together experts to explore the latest advancements in targeted protein degradation.

We look forward to seeing you there!

#PROTAC #TPD #DrugDiscovery

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Amazing @led3hub.bsky.social Lecture by @thewoolab.bsky.social! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3)
www.nature.com/articles/s41...

#TPD #DrugDiscovery #ChemBio #ChemSky #Degron

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We are very happy that Christina Woo (@thewoolab.bsky.social) visited us for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
#TPD #ChemBio #ChemSky

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TPD officer convicted in connection with Walmart theft fired following internal investigation
TPD officer convicted in connection with Walmart theft fired following internal investigation YouTube video by WTVG 13abc Action News | Toledo, OH

#TPD #officer convicted in connection with #Walmart theft fired following internal investigation

A #Toledo #Policeofficer convicted in connection with Walmart #theft in 2025 has been fired following an internal investigation.

digg.com/toledo/922Ts...
www.youtube.com/watch?v=5Zbj...

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⁉️How can policymakers support #education in #Sudan?

✅Develop long-term strategic plans
✅Coordinate with international, national & local initiatives
✅Recognize displaced communities as active partners
✅Invest in continuous #TPD
✅Adopt flexible policies for #EiE

➡️ inee.org/crisis-spotlight/sudan

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Of course, here great gals and guys from Lund University do most of the "real" work, and my mates from Captor Therapeutics made and characterized this beautiful compounds to work as MGs. My input was to provide proteomic analysis, still I'm quite contet with this one ;)

Enjoy! #proteomics #TPD

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#TargetedProteinDegradation #InducedProximity #MolecularGlue #TPD #eTPD #PROTAC #LYTAC #MoDEA #KineTAC #PROTAB #AbTAC #EpiTAC #REULR #GlueTAC #TICTAC #AUTAC #ATTEC #AUTOTAC #TrogoTAC #RIPR #RIPTAC #AgnoTAC #FragTAC #SHEDTAC

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Back from the #INGM retreat with strong science, stimulating discussions, and inspiring talks. Glad to present our technologies to target and degrade protein clusters. To the next year… #TPD #biomolecularcondensates

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#Thornton Town Hall Tonight (no public comment). Show up in person if you are able. Live stream here if you can't come in person: www.youtube.com/c/ThorntonCO...

#Flock #Palantir #LPR #TPD

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Very much looking forward to the @led3hub.bsky.social Lecture by Christina Woo (@thewoolab.bsky.social)! I am sure it will be a great one.

If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.

#ChemSky #ChemBio #DrugDiscovery #degrader

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We are looking forward to the LED3 Lecture of Christina Woo (@thewoolab.bsky.social) on February 26th. She will talk about "Rewriting Protein Modifications".

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #ChemicalProteomics #TPD

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A sweet little curly haired dog smiles for the camera.

A sweet little curly haired dog smiles for the camera.

A little curly furred dog wire a sign that said -
Pet Dogs
Read Books
Fight Facism 
January 26, 2026

A little curly furred dog wire a sign that said - Pet Dogs Read Books Fight Facism January 26, 2026

We didn't take signs. We had candles prepared but they weren't needed.
We arrived about 1615.
Found a nice group who were friendly & respectful. To include #TPD. Lotsa positive honking & a few sweet #dogs like Bugsy here. He & his Human have the right idea.
#PetDogs
#ReadBooks
#FightFascism

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We were there a little late. It was a nice sized group, friendly, respectful. We didn't get any "bad" vibe from #TPD.

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I have been so happy that #TPD has been with us, to protect and serve, as we have rallied and marched this past month.

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At each protest that we've attended, #TPD has been with us to "protect and serve". And, I thank them for that. 💙

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we hope you enjoyed this paper as much as we do! 😉😘

if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD

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It was very peaceful!
And #TPD was again making sure we were safe! Thanks, men and women in blue!

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🔥#meTPD–Driven Cancer #Vaccine
#iVAC degrades #PDL1, drives tumor antigen presentation, and reprograms cells into APC-like messengers. Awakens bystander memory #Tcells, turning cold tumors hot—robust CD8⁺ activation & superior tumor control in humanized mice & organoids.
#TPD

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Share to help!
Have you seen . . .
**Rickeyonn Talley** Temple, TX
www.missingkids.org/poster/NCMC/...
See something, say something . . .
24-Hour Hotline: 1-800-843-5678
Temple Police Department (TX) (254) 298-5500

#NCMEC #MissingKids #TPD #BobbyVForTheMissing

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ANALYSIS: Europe’s Nicotine Rulemaking – The Path Ahead Summary: The EU Commission has announced that it will propose changes to the EU’s laws on safer nicotine products next year, a year earlier than previously expected. There’s a good chance that the…

EU alert 🚨 The Commission will propose new rules on safer nicotine products in 2026, a year earlier than planned. Expect a push for flavour bans, pouch bans, online sales bans. This is the moment to pay attention. #TPD #HarmReduction clearingtheair.eu/post/analysi...

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#TPD

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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

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PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...

Last paper post of the year!

Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.

www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD

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POV: You have iron defficiency 🥲 (Yes, unfortunately, I am the one falling xD) /w @j0hnn0o.bsky.social and @thepitdwellers.bsky.social

#twitch #clip #tpd #thepitdwellers #peak

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Happy to share that my review "Clues for glues: from serendipity to nature's blueprints in degrader discovery" is now out: doi.org/10.1042/EBC2...

The field is moving fast, and there’s no shortage of open questions - what a great time to be thinking about where #molecularglues and #TPD go next!

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Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11 Proteolysis targeting chimeras (PROTACs) are an emerging therapeutic modality that induces protein degradation by recruiting E3 ligases. Most reported PROTACs recruit ubiquitously expressed E3 ligases, such as cereblon and the von Hippel-Lindau tumor suppressor. Of the additional 600+ E3 ligases, recruiting those with tissue-restricted expression is attractive for increasing the specificity of PROTACs. To this end, tissue-specific E3 ligases or E3 ligase-associated proteins that can be recruited for targeted protein degradation need to be identified. This work describes the first reported PROTAC that recruits the tissue-specific E3 ligase scaffolding protein MAGEA11. As an initial demonstration, a library of bromodomain and extra-terminal domain (BET)-targeting PROTACs that recruit MAGEA11 was synthesized. The library was screened in osteosarcoma U2OS cells, identifying lead compound 105B. 105B potently degrades BET proteins in U2OS osteosarcoma cell lines (BRD4 DC50 = 0.130 nM, Dmax = 78%) and KYSE180 esophageal squamous cell carcinoma cell lines (DC50 = 40 nM, Dmax = 70%), but shows no degradation in non-cancerous, MAGEA11-deficient HEK293T cells. Mechanistic studies confirmed 105B’s dependence on the ubiquitin-proteasome system and engagement of both MAGEA11 and BRD4. 105B decreased levels of BET-regulated gene products c-Myc, RUNX2, and KRT14; however, improvements are still necessary to affect selective cytotoxicity. This work reports the first example of a PROTAC recruiting a tissue-specific E3 ligase for cancer-restricted degradation of BET proteins and highlights the need for further development of MAGEA11-recruiting degraders. ### Competing Interest Statement The authors have declared no competing interest. * BCL-xL : B-cell lymphoma extra-large BET : Bromodomain and extra-terminal domain BD1, BD2 : Bromodomain 1, bromodomain 2 BRD2, BRD3, BRD4, BRDT : Bromodomain-containing proteins 2, 3, 4, and testis-specific (T) c-Myc : Myc proto-oncogene protein DC50 : Half-maximal degradation concentration DHFR : Dihydrofolate reductase Dmax : Maximum degradation achieved DMSO : Dimethyl sulfoxide E2F1 : E2F transcription factor 1 ESCC : Esophageal squamous cell carcinoma HER2 : Human epidermal growth factor receptor 2 HUWE1 : HECT, UBA, and WWE domain-containing E3 ubiquitin-protein ligase 1 IAP : Inhibitor of apoptosis protein Ki : Inhibition constant KRT14 : Keratin 14 MAGE : Melanoma antigen gene family MAGEA11 : Melanoma antigen family member A11 PEG : Polyethylene glycol PHOTAC : Photo-controllable proteolysis-targeting chimera PCF11 : Cleavage and polyadenylation factor 11 POI : Protein of interest PROTAC : Proteolysis-targeting chimera RUNX2 : Runt-related transcription factor 2 VHL : von Hippel–Lindau tumor suppressor protein National Institutes of Health, https://ror.org/01cwqze88, R35 GM140837-01, 5T32GM132029-06, T32GM008347

Exciting @biorxivpreprint.bsky.social by the group of Gunda Georg. They developed a tissue-specific PROTAC that recruits the E3 ligase scaffolding protein MAGEA11 that is highly expressed in many cancers and otherwise only in sperm and placenta. www.biorxiv.org/cont...
#TPD #ChemSky #ChemBio

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E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular ...

#Article in #MedComm

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy doi.org/10.1002/mco2...

#cancer #E3_UbiquitinLigase #AD #PD #PROTAC #TPD

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Super funds accused of delaying insurance claims The regulator has found that while some superannuation funds have improved insurance claims response times, others are still falling short, with long delays in relation to mental health claims. 

Super funds accused of delaying insurance claims #insurance #tpd #totalandpermanentdisability

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Does anybody else see #taylorswift ‘s FLORIDA! from #tpd as a nice companion piece to No Body No Crime from #evermore ? This makes all the sense to me.

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