Top: Schematic of Bayesian decoding from a simulated network of tonotopically organized neurons whose tuning parameters are derived from the population data recorded from the auditory cortex (ACx) or inferior colliculus (IC) of either WT or Fmr1 KO rats. Bottom: Schematic summarizing results. Cortical gain enhancement in FXS may act to preserve signal-to-noise ratios and signal detection threshold at the expense of sound sensitivity and fine feature discrimination.
Atypical #sensory processing is a common symptom in #AutismSpectrumDisorders. This study reveals impaired frequency discrimination in a rat model of #FragileXsyndrome that is associated with #auditory cortical hyperexcitability & degraded tuning quality #FraX @plosbiology.org 🧪 plos.io/4kl46Pk