Work pursuing #GPC3 #radiotheranostics using PDX models could validate these findings and offer a much needed therapeutic option for this rare, difficult to treat cancer.
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#GPC3
Latest posts tagged with #GPC3 on Bluesky
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Posts tagged #GPC3
For this story, we asked whether we could explore expression in patient samples (PDXs, PDOs, cell lines, IHC of tumors) more sytematically and whether we could use #GPC3 as a #radiopharmaceutical target for #NEPC.
Turns out that GPC3 is highly enriched in patients with AR-/NE+ prostate cancers!
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So, it's perhaps no surprise that when we came across the work by out of Duke showing that #GPC3 was also expressed in neuroendocrine prostate cancer #nepc, it piqued our interest!
doi.org/10.1002/path...
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As some of you might know, our group has long been interested in using #GPC3 as an #HCC-selective target to develop #radiopharmaceuticals.
Example: jnm.snmjournals.org/content/64/7...
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