Latest posts tagged with #HCC on Bluesky
Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predicts Cachexia and Prognosis in Hepatocellular Carcinoma Patients
This research evaluated the predictive role of FLIS in #HCC patients with #Cachexia, suggesting that FLIS may facilitate early identification and #Prognostic assessment, and offering new perspectives for improving patient care. #medsky
To read: doi.org/10.1007/s115...
Retrospective Analysis of Radiofrequency Ablation in Patients with Small Solitary Hepatocellular Carcinoma: Survival Outcomes and Development of a Machine Learning Prognostic Model
Using the #SEERDatabase, this study demonstrates promising #SurvivalOutcomes for patients with solitary #HCC lesions ≤5 cm treated with #RFA, validated by stratified analyses & #AIDriven models, promising a novel #therapeutic strategy. #medsky
Read: doi.org/10.1007/s115...
SWISS LEAGUE | HC La Chaux-de-Fonds signs Santiago Näf from EHC Chur #HCC #EHCChur swisshockeynews.ch/en/shn/men/swiss-hockey/...
This study shows that single-cell profiling of #HCC under anti-PD-1 therapy reveals #Tcell exhaustion trajectories linked to tumor–immune crosstalk, highlighting exhaustion as a key target to improve #immunotherapy outcomes. #SingleCellRNASequencing
#OpenAccess: doi.org/10.1016/j.ge...
MEDICAL REPORT | HCC's Noam Micheletti done for the season #HCC swisshockeynews.ch/en/medical-feed/nl-med/h...
DISCIPLINARY | Four-game suspension for HCC's Loïc In-Albon #HCC swisshockeynews.ch/en/shn/disciplinary/four...
Researchers used machine learning to identify subgroups of patients with unresectable #HepatocellularCarcinoma treated with #atezolizumab and #bevacizumab with different patterns of progression and prognostic trajectories.
#HCC #hepatology #oncology
SheBelieves Cup Matchday 2 of 3 starts today, but we’re already working up an appetite for the FINAL. 😋
Don't forget to support local this weekend! 💜
#HCC #KenameSport #SheBelievesCup #Newark #Ironbound
#HCC: 3 enfoques terapéuticos que están cambiando el panorama clínico
🔹 PD-1
🔹 Anti-VEGF
🔹 TKI
📎 Más información: dengyuepharma.com
📧 info@dengyuemed.com
#CarcinomaHepatocelular #InmunoOncología #AntiVEGF #TKI #PD1 #TerapiaSistémica #DengYueMedicinasEnHongKong
#ICE and #LEO presence was reported at/on #HCC Houston City College - Eastside Campus at 6815 Rustic St. near Bldg D. early A.M. Eastside is also a polling location. Be vigilant.
Check www.harrisvotes.com/Vote-Centers for nearby options & wait times. Get out and #vote #Houston! #HarrisCo #TX #Texas
Adición de camrelizumab y rivoceranib a la quimioembolización transarterial mejora la supervivencia libre de progresión en pacientes con carcinoma hepatocelular irresecable #HCC #TACE ascopubs.org/doi/full/10....
DISCIPLINARY | Loïc In-Albon has been provisionally suspended #HCC swisshockeynews.ch/en/shn/disciplinary/loic...
Illustration of TFAP4-mediated reactivation of TERT in non-HBV-associated hepatocellular carcinoma. Alcohol exposure increases CTCF expression, which promotes transcription of TFAP4. TFAP4 binds the TERT promoter (at approximately −111 nt), enhancing TERT gene transcription. Elevated TERT expression increases telomerase activity, stabilizes telomeres, and supports hepatocellular carcinoma progression and metastasis. The pathway is depicted within the nucleus of an HCC cell, leading to tumor growth in non-viral-associated liver cancer.
📎 Commentary Spotlight
Eversole & Chakraborty discuss how TFAP4 “unleashes” TERT activity in non-viral liver cancers and highlight therapeutic implications of targeting the TFAP4–TERT interaction.
🔗 doi.org/10.47248/chp...
#HCC #CancerBiology
Schematic model of telomerase reactivation in non-HBV-associated hepatocellular carcinoma. CTCF binds to the TFAP4 promoter and increases TFAP4 expression. TFAP4 then binds directly to the TERT promoter, enhancing TERT mRNA transcription. Increased TERT expression leads to elevated telomerase activity and stabilization of telomeres. Ethanol exposure further upregulates TFAP4 and TERT in non-HBV HCC cells, while this regulatory pathway appears limited in HBV-associated HCC.
📘 CHP Archive Spotlight #08
Original Research (2024) | Lim et al.
TFAP4 directly reactivates TERT in non-HBV HCC — independent of promoter mutation.
CTCF → TFAP4 → TERT axis drives telomerase activation, especially in alcohol-related tumors.
🔗 doi.org/10.47248/chp...
#HCC #TERT #Telomerase
Illustration of TFAP4-mediated reactivation of TERT in non-HBV-associated hepatocellular carcinoma. Alcohol exposure increases CTCF expression, which promotes transcription of TFAP4. TFAP4 binds the TERT promoter (at approximately −111 nt), enhancing TERT gene transcription. Elevated TERT expression increases telomerase activity, stabilizes telomeres, and supports hepatocellular carcinoma progression and metastasis. The pathway is depicted within the nucleus of an HCC cell, leading to tumor growth in non-viral-associated liver cancer.
📎 Commentary Spotlight
Eversole & Chakraborty discuss how TFAP4 “unleashes” TERT activity in non-viral liver cancers and highlight therapeutic implications of targeting the TFAP4–TERT interaction.
🔗 doi.org/10.47248/chp...
#HCC #CancerBiology
#Review
#Insulin resistance: #mechanisms and therapeutic interventions doi.org/10.1186/s435...
#DrugResistance #Metabolic #dysregulation #HepatocellularCarcinoma #HCC
Clinical Snapshot: Mindfulness in #HCC 📊
• Data: IMBI significantly improved resilience & mindfulness (P < .001).
• Finding: Reduced anxiety & depression post-intervention.
Read: https://bit.ly/4rycCPn
#Oncology #MentalHealth #HepatocellularCarcinoma
• 80.6% of #HCC patients using 5% #lidocaine patches required zero opioids post-RFA.
• Median MME: 0.0 mg (lidocaine) vs 5.6 mg (control).
• Pain scores remained consistent across cohorts.
Read the review: https://bit.ly/46Z8PlX
#Oncology #CancerPain #HepatocellularCarcinoma
Don't miss on latest issue!
Including CME on #Diabetes and articles on Salmonella enteritidis #meningitis, #metabolicsyndrome, hepatocellular carcinoma #HCC and more! ⬇️
Big news from ABK Biomedical🎉 We’ve completed enrollment in ROUTE90, our pivotal FDA study evaluating Eye90 microspheres for primary liver cancer (HCC).
120 patients. International sites. The largest prospective FDA IDE trial ever run for Y90 radioembolization.
#livercancer #HCC #Oncology
Dr. Jewett's review examines NK cell immunotherapies for hepatocellular carcinoma, exploring ADCC, pyroptosis & cGAS-STING pathways in preclinical/clinical studies.
Free until March 15: dl.begellhouse.com/journals/2ff...
#HCC #NKCellTherapy
This review describes the role of the transcription factor SOX4 in #LiverDisease & #HCC progression, highlighting it as a promising #TherapeuticTarget to modulate #Fibrogenesis and overcome #DrugResistance.
#OpenAccess: doi.org/10.1016/j.ge...
Can natural dimers fight liver cancer? 🧪
Research in CJNM identifies Atramacronins A–P, novel sesquiterpenoids from Atractylodes macrocephala with potent anti-tumor activity against Hep3B, HepG2, and Huh7 cells.
🔗 Read more on ScienceDirect
#HCC #Oncology #NaturalProducts #CJNM
#CancerAssociatedFibroblasts -derived fibronectin EDA drives #Sorafenib resistance in #HCC via SHMT1 activation, highlighting a novel fibroblast-tumor interaction that governs therapeutic response in #LiverCancer.
#OpenAccess: doi.org/10.1016/j.ge...
SWISS LEAGUE | HC La Chaux-de-Fonds adds three new players to their roster #HCC swisshockeynews.ch/en/shn/men/swiss-hockey/...
Upregulated STIM1 enhances SOCE in #sorafenib-resistant #HCC, activating CaN-NFAT to drive #SLC7A11 transcription, boost GSH, and suppress #ferroptosis; blocking this axis with SKF96365 restores sorafenib sensitivity.
#OpenAccess: doi.org/10.1016/j.ge...
At Curitics Health, we focus on embedding risk adjustment intelligence directly into care workflows supporting clinicians without adding administrative burden.
#RiskAdjustment #HCC #CodingAccuracy #MedicareAdvantage #ValueBasedCare #HealthcareOperations
Surgical resection was associated with superior long-term oncologic outcomes compared with radiofrequency ablation for patients with very early stage hepatocellular carcinoma (#HCC) with single tumors sized 2 cm or smaller.
Read here: https://bit.ly/3ZHQiqv
#RareDisease #Oncology
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma
AKR1B1-driven #MetabolicReprogramming sustains #DrugResistance in #HCC, while #epalrestat restores sensitivity—positioning AKR1B1 as both #biomarker and therapeutic target to overcome systemic resistance. @tsinghuauniversity.bsky.social
#STTT: doi.org/10.1038/s413...
