#GenomicInstability

@narjournal.bsky.social

1 month ago

⭐ Explore the NARCAN 5th Anniversary Symposium Collection!
🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more!
Read here: lnkd.in/ezznFh2f
#NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

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Rami I. Aqeilan

@ramiaqeilan.bsky.social

1 month ago

Our findings also point to transcriptional addiction as a cancer-specific vulnerability.

Huge congratulations to Osama for his perseverance and outstanding work, and to all co-authors for this collective achievement.

#ScienceAdvances #CancerResearch #GenomicInstability #DNARepair #SuperEnhancers

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Arrosan Rajalingam

@arrosan.bsky.social

5 months ago

Protecting double Holliday junctions ensures crossing over during meiosis - Nature Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

I remember presenting this paper from @hunterlab.bsky.social in our journal club a year ago, when it was still on bioRxiv. I’m delighted to see it now published in Nature!

www.nature.com/articles/s41...

#Cohesion #Development #Genomicinstability #Meiosis

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OncoDaily

@oncodaily.bsky.social

9 months ago

Aneuploidy in Cancer: Mechanisms, Consequences, and Therapeutic Implications - OncoDaily Aneuploidy in cancer fuels genomic instability, tumor evolution, immune evasion, and therapy resistance. Learn its mechanisms, consequences, and clinical relevance.

Aneuploidy in Cancer: Mechanisms, Consequences, and Therapeutic Implications

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Aneuploidy #TumorGenetics #GenomicInstability #CancerBiology

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Oliver Mortusewicz

@mortusewicz.bsky.social

9 months ago

Redirecting

🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"

👉 doi.org/10.1016/j.mo...

#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil