#ReplicationStress

Molecular Systems Biology

@molsystbiol.org

8 months ago

@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....

Kavli Institute for Nanoscience Discovery, University of Oxford

@kavlioxford.bsky.social

8 months ago

#DNAReplication
#GenomeStability
#MolecularBiology
#Biophysics
#SingleMolecule
#FluorescenceMicroscopy
#ForceSpectroscopy
#Replisome
#CancerResearch
#CellBiology
#MolecularMachines
#LiveScience
#ReplicationStress

Nucleic Acids Research

@narjournal.bsky.social

9 months ago

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in

New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social

Oliver Mortusewicz

@mortusewicz.bsky.social

9 months ago

🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"

👉 doi.org/10.1016/j.mo...

#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil

@eliamoarbess.bsky.social

1 year ago

Just as the heart is essential for life, TopBP1 is crucial for cell survival.

Cells need nuclear actin to relocate harmful DNA damage to safe areas.

IGH - MPL France

#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch

TRAstonDrs

@castltrastondrs.bsky.social

2 years ago

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...

as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K