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HIV and AIDS research for the 21st Century. Genetic, proteomic, immunological, environmental, and experimental differences ensure that experiments on animals can never fully capture the complexity of HIV or AIDS. Chimpanzees—once considered the gold standard for HIV research—were spared further use after the NIH’s 2015 moratorium. More recently, the CDC’s decision to close its monkey laboratories underscores the same truth: we don’t need these animals to do good science. The future of HIV and AIDS research lies in advanced, human-relevant methods: multi-omics, bioinformatics, in silico modeling, analysis of “HIV controller” cells, and better use of patient tissues and other clinical samples.

HIV and AIDS research for the 21st Century. Genetic, proteomic, immunological, environmental, and experimental differences ensure that experiments on animals can never fully capture the complexity of HIV or AIDS. Chimpanzees—once considered the gold standard for HIV research—were spared further use after the NIH’s 2015 moratorium. More recently, the CDC’s decision to close its monkey laboratories underscores the same truth: we don’t need these animals to do good science. The future of HIV and AIDS research lies in advanced, human-relevant methods: multi-omics, bioinformatics, in silico modeling, analysis of “HIV controller” cells, and better use of patient tissues and other clinical samples.

We owe it to those who fought—and to those still waiting for answers—to move beyond the past and embrace science that reflects the "human" in human immunodeficiency virus.

#HIVInnovation #HIVScience #StopHIVTogether

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Colourful i-Base graphic. The main text reads: BHIVA interim update. Important changes to adult UK HIV guidelines. At the top is i-Base’s website address: I hyphen base dot info. At the bottom it says, subscribe by email. A smaller, tilted square graphic on the right, reads: HTB news. 2025. HIV treatment, prevention, access, and more. The colours used in the image are two shades of dark azure, faded indigo, lilac, light blue, dark magenta, grey-green, light turquoise, maroon, pastel pink, orange, dark blue, mustard, red, and white.

Colourful i-Base graphic. The main text reads: BHIVA interim update. Important changes to adult UK HIV guidelines. At the top is i-Base’s website address: I hyphen base dot info. At the bottom it says, subscribe by email. A smaller, tilted square graphic on the right, reads: HTB news. 2025. HIV treatment, prevention, access, and more. The colours used in the image are two shades of dark azure, faded indigo, lilac, light blue, dark magenta, grey-green, light turquoise, maroon, pastel pink, orange, dark blue, mustard, red, and white.

#BHIVA issues update to #HIV guidelines for adults. We explain the main changes here:

i-base.info/htb/52587

#HIVsky #HIVguidelines #HIVtreatment #HIVpositive #PLWH #HIVscience #Undetectable #UequalsU #InjectableART #LongActingART #abacavir #cabotegravir @bhiva.bsky.social @bashhuk.bsky.social

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🏨 Planning for EACS 2025 in Paris 🇫🇷?

✅ Register: https://loom.ly/larUmWc
✅ Book accommodation: https://loom.ly/rYDgyZg
✈️ Check travel & discounts: https://loom.ly/5j37ABk

#EACS2025 #HIVScience #Paris

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1 month to go! ⏳
Paris hosts the 20th European #AIDS Conference – EACS 2025, 15–18 Oct 2025 🇫🇷
📽️ Watch the invitation from the #EACS2025 Conference Co-Chairs: https://loom.ly/KL-Uwos
Theme: From Science to Implementation
#EACS2025 #HIVScience

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How HIV enters the genome – Researchers identify previously unknown mechanism | German Center for Infection Research Researchers at the German Center for Infection Research (DZIF) at Heidelberg University Hospital have decoded a previously unknown mechanism by which

www.dzif.de/en/how-hiv-e...
@dzif.bsky.social @dfg.de @natmicrobiol.nature.com #HIV #HIVScience #HIVCure #Nucleus #Nucleararchitecture #Splicing #R-loops #Genomeorganization

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What's the link between HIV Research and Heart Health? #hivresearch #AIDSResearch #HIVScience #HeartHealth #HeartDisease

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“My goal was to fight stigma and make people feel strong, loved, and safe.” – Dolice Niyomukiza. Her design for #HIVUnwrapped, created with @edwinjbernard.bsky.social for @hivjustice.net, premiered today at #IAS2025 in Kigali.
#HIVJustice #HIVScience Learn more: www.hivjustice.net/news/hiv-unw...

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We must fill the void in global #HIV #AIDS care without
#PEPFAR - with renewed focus on our collective goal to bring HIV/AIDS under control by 2030, write ‪
@linda-gailb.bsky.social et al @bmj.com @iasociety.bsky.social
#HIVScience #IAS2025 bmj.com/content/390/...

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⏰Just three more days to go until the start of #IAS2025!

Register for the conference here:
www.iasociety.org/conferences/...

#HIVScience #GlobalHealth

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i-Base rectangular graphic in red, white, black and grey. Main text reads, IAS 2025. Kigali, Rwanda, and online. To the left of this is a spiral based on patterns described below and the red AIDS ribbon. The i-Base website address, i hyphen base dot info, is in the top left corner. In the bottom right corner, text reads, HTB news. Subscribe by email. There are horizontal strips of the IAS 2025 signature graphics at the top and bottom of the image. They are made up of squares, each containing its own unique pattern based on traditional Rwandan art.

i-Base rectangular graphic in red, white, black and grey. Main text reads, IAS 2025. Kigali, Rwanda, and online. To the left of this is a spiral based on patterns described below and the red AIDS ribbon. The i-Base website address, i hyphen base dot info, is in the top left corner. In the bottom right corner, text reads, HTB news. Subscribe by email. There are horizontal strips of the IAS 2025 signature graphics at the top and bottom of the image. They are made up of squares, each containing its own unique pattern based on traditional Rwandan art.

i-Base reports from #IAS2025. Check back at this link for daily reports from the conference, follow updates here or subscribe by email:

i-base.info/htb/51480

#HIV #HIVsky #ResearchSky #HIVscience #HIVresearch #HIVtreatment #HIVprevention #ResearchMatters #Kigali #Rwanda @iasociety.bsky.social

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i-Base graphic for IAS 2025. The main text reads: Scientists and advocates call to action. Keep politics out of public health to end the HIV pandemic. At the top is i-Base’s website address: I hyphen base dot info. In the bottom left it says: HIV treatment bulletin. In the bottom is a white box, containing the words: IAS 2025. 13th to 17th July. Above this is a spiral next to the red AIDS ribbon. There are horizontal strips of the IAS 2025 signature graphics at the top and bottom of the image. They are made up of squares, each containing its own unique pattern based on traditional Rwandan art. The colours used in the image are red, black, white and grey.

i-Base graphic for IAS 2025. The main text reads: Scientists and advocates call to action. Keep politics out of public health to end the HIV pandemic. At the top is i-Base’s website address: I hyphen base dot info. In the bottom left it says: HIV treatment bulletin. In the bottom is a white box, containing the words: IAS 2025. 13th to 17th July. Above this is a spiral next to the red AIDS ribbon. There are horizontal strips of the IAS 2025 signature graphics at the top and bottom of the image. They are made up of squares, each containing its own unique pattern based on traditional Rwandan art. The colours used in the image are red, black, white and grey.

Kigali Call to Action: sign the petition.

Scientists urge world leaders to recommit to global #HIV response ahead of #IAS2025 conference:

i-base.info/htb/51418

Demands include supporting global research & separating politics from science.

#HIVsky #ResearchSky #HIVscience @iasociety.bsky.social

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How is HIV science around the world navigating US funding cuts? Follow us as we bring you exclusive coverage from the 13th IAS Conference on HIV science in Kigali, Rwanda. #IAS2025 #HIVScience

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an elderly man is standing next to a robot that says the bots are taking over ! ALT: an elderly man is standing next to a robot that says the bots are taking over !

Automation is great—but not perfect. 🤖❌

In HIV behavioral trials, fully automated systems should yield clean data… if only humans were **infallible, reliable, and predictable.** 🙃

Join us to learn why redundancy matters in research!
#ClinicalResearch #HIVScience

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🎤 Championing change in HIV advocacy

Honoured to have had Daniel Driffin join us at #IASPCC Advocacy Academy to share the power of community-driven HIV advocacy.

🌐 Organized by the IAS in partnership with Southern AIDS Coalition, Community Education Group & Gilead Sciences.
#HIVScience #HIVEquity

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youtu.be/vuAj-Ivn0Hk - VIDEO. - Automation is great—but not perfect. 🤖❌

In behavioral trials, fully automated systems should yield clean data… if only humans were infallible, reliable, and predictable. 🙃

Join us to learn why redundancy matters in research!
#ClinicalResearch #HIVScience

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Tracking HIV persistence across T cell lineages during early ART-treated HIV-1-infection using a reservoir-marking humanized mouse model | Nature Communications Human immunodeficiency virus (HIV) infection depletes CD4 T-cells, and long-term persistence of latent virus prevents full clearance of HIV even in the presence of effective antiretroviral therapy (ART), Here we present the HIV-1-induced lineage tracing (HILT) system, a model that irreversibly marks infected cells within a humanized mouse model, which detects rare latently infected cells. Immunodeficient mice transplanted with genetically modified hematopoietic stem cells develop a human immune system, in which CD4 T-cells contain a genetic switch that permanently labels cells infected by HIV-1 expressing cre-recombinase. Through single-cell RNA sequencing of HILT-marked cells during acute infection and post-ART treatment, we identify distinct CD4+ T-cell transcriptional lineages enriched in either active or latent infections. Comparative gene expression analysis highlights common pathways modulated in both states, including EIF2, Sirtuin, and protein ubiquitination. Critical regulator

Revealed: HIV persistence across T cell lineages in early ART-treated infection. Using a novel model, track rare latent cells in a humanized mouse system. #HIVScience PMID:40044684, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57368-7 #Medsky #Pharmsky #RNAsky 🧪

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Home - Positive Women Victoria Positive Women Victoria provides peer support, information and advocacy for women who are living with HIV.For over 30 years, Positive Women Victoria has responded to the changing needs of women living...

Positive Women Victoria (in Australia) is now on Blue Sky.

Our posts aim to support women living with HIV everywhere. But also all people living with HIV to live their best lives ever. #HIV #HIVwomen #HIVscience #HIVcure.

Learn, watch, read, listen to personal stories at:
www.positivewomen.org.au

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