#IONS

StockTitan

@stocktitan.net

2 weeks ago

Olezarsen sNDA accepted by the FDA for Priority Review for the treatment of severe hypertriglyceridemia (sHTG) Ionis (Nasdaq: IONS) announced the FDA has accepted the sNDA for olezarsen in severe hypertriglyceridemia (sHTG) and granted Priority Review, with a PDUFA target action date of June 30, 2026. The filing is supported by Phase 3 CORE and CORE2 results.In those studies, olezarsen showed up to a 72% placebo-adjusted triglyceride reduction, an 85% reduction in acute pancreatitis events, and nearly 90% of treated patients reached triglycerides <500 mg/dL; safety and tolerability were described as favorable.

#IONS Olezarsen sNDA accepted by the FDA for Priority Review for the treatment of severe hypertriglyceridemia (sHTG)

www.stocktitan.net/news/IONS/olezarsen-s-nd...

Dr Peter Sherrell

@nanoin3d.bsky.social

2 weeks ago

#Ions - They make beautiful colours in the sky ✨, but what do they do when we get them 'stuck' in a plastic film ⁉️

with @andrissutka.bsky.social in @apsphysics.bsky.social #PRL we show the film transforms into an electrically responsive⚡surface!

link.aps.org/doi/10.1103/...

#physics 🧪 #chemsky

Razhiel @ Starlight Within

@starlightwithin.bsky.social

1 month ago

Grief to Gratitude: Embracing the Inner Pathway to Healing and Peace – ConnectIONS Live Explore consciousness as a pathway through grief. Join Steven Ferrara for meditation and reflective writing drawn from his 20-year journey from loss to peace.

This free webinar sounds useful for anyone dealing with grief and loss:
noetic.org/event/grief-...
(organized by the Institute of Noetic Sciences)

#IONS #InstituteOfNoeticSciences #grief #loss

Moss May 🏴‍☠️🏳️‍🌈🦘🌏

@lozwood.bsky.social

2 months ago

The sound of clouds and the conversation that follows #clouds #sound #thunder #rain #shade #cool #fancystuff #ions #birds #video #sky #observations

CompBioPhys

@compbiophys.bsky.social

2 months ago

👉 Together, these findings will enable better integration of CCS measurements into protein identification and quantification pipelines, improving the performance of ion mobility-based proteomics.

#CollisionalCrossSection #ML #Peptide #Conformation #IonMobilitySpectrometry #ions

Rob McConnell

@robmcconnell.bsky.social

2 months ago

Rob McConnell Interviews - DR. DEAN RADIN - The Institute of Noetic Sciences Dr. Dean Radin is a pioneering scientist and the Chief Scientist at the Institute of Noetic Sciences (IONS), internationally recognized for his groundbreaking research into consciousness, psi phenomena, and the limits of human potential. With a background in electrical engineering and psychology, and having worked at institutions such as Bell Labs, Princeton, and SRI International, Dr. Radin applies rigorous scientific methodology to subjects often considered controversial, including telepathy, precognition, intention, and mind–matter interactions. Through his work at IONS, he seeks to bridge science and spirituality, challenging conventional assumptions about reality while advancing a data-driven understanding of consciousness and human experience.

📣 New Podcast! "Rob McConnell Interviews - DR. DEAN RADIN - The Institute of Noetic Sciences" on @Spreaker #awareness #consciousness #evidence #exploration #intention #intuition #ions #mindmatter #neuroscience #noetic #parapsychology #perception #phenomena #precognition #psi #quantum #reality

Wendy's Coffeehouse Curious

@lite4one.bsky.social

3 months ago

Tom Matte unlocks ‘upsight vision,’ a new way to tap untapped human potential YouTube video by America's Small Business Network

A mental health crisis over a decade ago evolved into “Upsight Vision,” a capacity to perceive and engage with external #holographic images. He claims he can help individuals unlock creative blocks, analyze subconscious patterns, and access a level of intelligence beyond AI. #PSI #Noetic #IONS

Rob McConnell

@robmcconnell.bsky.social

3 months ago

Rob McConnell Interviews - KIM DANDURAND - Would You Stick Your Head in a Microwave Aulterrs is an Idaho company, is a pioneer in the research and development of products that protect consumers from the potentially negative effects of electromagnetic fields (EMFs) emitted by cell phones, computers, microwave ovens, cordless phones, televisions, video games, and other electronic devices. The Neutralizer™ , a small holographic disc, is Aulterra's flagship product. It is the only product on the market today which has been scientifically proven to be significantly effective in reducing/neutralizing the harmful effects of electromagnetic waves. Electromagnetic fields are all around us. In their natural form they are harmless. When manmade they disrupt the energy patterns of the human body. The Neutralizer and other Aulterra products contain a proprietary blend of natural materials (powdered rocks) which neutralize harmful emissions. The power of this material was first discovered when it was used to neutralize and remove lead and zinc from a landfill during an environmental cleanup project. The company is currently developing a new product line called Aulterra Components. These products will be used to reduce the amount of electromagnetic emissions emitted from an electronic device. Compliance with emissions directives of international regulatory bodies such as the FCC and CE is required for certification before products can be sold in the open market.

📣 New Podcast! "Rob McConnell Interviews - KIM DANDURAND - Would You Stick Your Head in a Microwave" on @Spreaker #balance #bioenergetics #biophysics #detoxification #emf #energy #frequency #harmonics #healing #innovation #integrative #inventor #ions #neutralization #protection #purification

Opto-Electronic Advances

@optoelectronadv.bsky.social

3 months ago

#OEA_highlight Halide perovskite volatile unipolar nanomemristor doi.org/10.29026/oea... by Prof. #Sergey_Makarov #Aleksandra_Furasova @xyl85615557 @itmo_uni #perovskite #nanocrystals #nanomemristor #volatile #memory #switching #ions #migration

Display Me Not Display Me Do

@scotsbme.bsky.social

3 months ago

-

Static life

#Static #Vinyl #Zerostat #Piezoelectric #PhilipEdwardSecker #Secker #Milty #anti-static #ions #audiophile #Dust #Zerostat3 #Gun #AntiGunLaw #Snap #Crackle #Pop #LP #7"Single #Album #VinylRecord #Turntable #TechnicsSL-1200

StockTitan

@stocktitan.net

3 months ago

Ionis receives U.S. FDA Breakthrough Therapy designation for zilganersen for Alexander disease (AxD) Ionis (Nasdaq: IONS) announced that the U.S. FDA granted Breakthrough Therapy designation to zilganersen for Alexander disease (AxD), a rare, progressive neurological disorder with no approved disease-modifying treatments.The FDA decision is supported by pivotal study topline results: zilganersen 50 mg improved 10-Meter Walk Test gait speed by 33.3% versus control (p=0.0412) at week 61, with favorable safety and consistent secondary endpoint benefits. Ionis plans an NDA submission in Q1 2026 and is working to start a U.S. Expanded Access Program.Ionis said this designation may expedite review and follows a recent Breakthrough Therapy designation for another program, underscoring the company’s late-stage pipeline focus.

#IONS Ionis receives U.S. FDA Breakthrough Therapy designation for zilganersen for Alexander disease (AxD)

www.stocktitan.net/news/IONS/ionis-receives...

StockTitan

@stocktitan.net

3 months ago

#IONS Ionis receives U.S. FDA Breakthrough Therapy designation for olezarsen for severe hypertriglyceridemia (sHTG)

www.stocktitan.net/news/IONS/ionis-receives...

StockTitan

@stocktitan.net

4 months ago

DAWNZERA™ (donidalorsen) receives positive opinion from CHMP, recommended for approval in EU for hereditary angioedema (HAE) Ionis Pharmaceuticals (Nasdaq: IONS) and Otsuka announced the CHMP has adopted a positive opinion for DAWNZERA (donidalorsen) for routine prevention of hereditary angioedema (HAE) in adults and adolescents aged 12 and older.The opinion is now with the European Commission, with a decision expected in Q1 2026. CHMP based its recommendation on Phase 3 OASIS-HAE and OASISplus results showing a significant, sustained reduction in mean monthly HAE attack rate, including with autoinjector self-administration. DAWNZERA received FDA approval in August 2025.

#IONS DAWNZERA™ (donidalorsen) receives positive opinion from CHMP, recommended for approval in EU for hereditary angioedema (HAE)

www.stocktitan.net/news/IONS/dawnzeratm-don...

StockTitan

@stocktitan.net

4 months ago

Ionis Prices Convertible Notes Offering to Refinance 2026 Convertible Notes Ionis (NASDAQ: IONS) priced $700.0 million aggregate principal of 0.00% convertible senior notes due 2030, with an underwriter option for an additional $70.0 million. The offering is expected to close on November 17, 2025, with estimated net proceeds of approximately $682.8 million (or $751.2 million if the option is exercised).Ionis expects to use about $267.6 million of net proceeds to repurchase $200.0 million aggregate principal of its 0% convertible notes due 2026 via concurrent repurchase transactions and the remainder for additional repurchases, repayment at maturity, and general corporate purposes. Initial conversion rate is 10.1932 shares per $1,000 (approx. $98.10 per share), a ~35.0% premium to the Nov 12, 2025 share price. Notes mature Dec 1, 2030 and are non‑interest bearing.

#IONS Ionis Prices Convertible Notes Offering to Refinance 2026 Convertible Notes

www.stocktitan.net/news/IONS/ionis-prices-c...

Paula Rossi

@elementalmusings.bsky.social

4 months ago

Cornucopia Nature serves up a bounty of ions. Let us give thanks...

Only two electrons separate elemental calcium from its typical ion – But this makes all the difference to the animals that depend on it.
#chemsky #chemistry #physiology #ions

StockTitan

@stocktitan.net

4 months ago

Ionis Announces Proposed Convertible Offering to Refinance 2026 Convertible Notes Ionis (NASDAQ: IONS) announced on November 11, 2025 a proposed private placement of $700.0 million aggregate principal amount of Convertible Senior Notes due 2030, with an initial purchaser option for up to an additional $70.0 million. The notes will be unsecured, pay interest semiannually, and on conversion may be settled in cash, shares, or a combination at Ionis’ election. The offering is to qualified institutional buyers under Rule 144A.Use of proceeds: Ionis expects net proceeds to be used to repurchase or repay its 0% Convertible Senior Notes due 2026, including possible concurrent negotiated repurchases, with any remainder for general corporate purposes. Pricing, interest rate, and conversion rate will be determined at pricing.

#IONS Ionis Announces Proposed Convertible Offering to Refinance 2026 Convertible Notes

www.stocktitan.net/news/IONS/ionis-announce...

Mark Anthony, JD Psychic Explorer

@markanthonyjd.bsky.social

4 months ago

A FEW SPOTS STILL AVAILABLE. The Friday Light Circle sold out, but there are a few spots still available for this Saturday. For info and tickets: www.eventbrite.com/e/mark-antho... #grief #healingfromgrief #mediumship #afterlife #edgarcayce #iands #ions #foreverfamiy #markanthonypsychiclawyer

StockTitan

@stocktitan.net

4 months ago

Groundbreaking pivotal study results of olezarsen for severe hypertriglyceridemia (sHTG) presented as a late breaker at AHA Scientific Sessions Ionis (Nasdaq: IONS) reported positive pivotal Phase 3 CORE and CORE2 results for olezarsen in severe hypertriglyceridemia (sHTG) on November 8, 2025. In nearly 1,100 patients, olezarsen achieved up to a 72% placebo-adjusted mean reduction in fasting triglycerides at six months with sustained reductions to 12 months.Key outcomes: 86% of treated patients reached TGs <500 mg/dL; adjudicated acute pancreatitis events fell by 85% (p<0.001); NNT=20 overall, NNT=4 in highest-risk subgroup. Data were presented at AHA and published in NEJM. Ionis plans an FDA supplemental NDA submission by year-end and will host a webcast Nov 8 at 3:00 p.m. ET.

#IONS Groundbreaking pivotal study results of olezarsen for severe hypertriglyceridemia (sHTG) presented as a late breaker at AHA Scientific Sessions

www.stocktitan.net/news/IONS/groundbreaking...

Pure Science

@purescience.news

4 months ago

New quantum computing hardware sorts ions for computation Quantum computers based on ions or atoms have one major advantage: the hardware itself isn’t manufactured, so there’s no device-to-device variability. Every atom is the same and should perform similarly...

New quantum computing hardware sorts ions for computation #Science #Physics #QuantumPhysics #QuantumComputing #Ions #Innovation

Paula Rossi

@elementalmusings.bsky.social

4 months ago

A Horse of a Different Color Neutral atoms are pretty chill. But an atom that has lost or gained electrons is another matter.

What does a tribe of ancient Greeks have in common with atoms that have lost or gained electrons? To find out, read this post… #chemistry #introchem #chemsky #ions

RichardJR

@electricbluesfan.bsky.social

5 months ago

3/9
For about five days each month, as the Moon passes behind the Earth, it is shielded from the #SolarWind and instead gets bathed in this #EarthWind.

This stream of particles, including #high-energy #oxygen #ions, pelts the #lunar surface and triggers chemical reactions.

#Geology

Phyclops Project - We Listen To Plants

@phyclopsproject.bsky.social

6 months ago

At what speed(s) do #ions and electrical signals travel through a #plant stem, in this case #avocado?
I measured this with the device pictured in the previous post. Here I show a histogram (4 days of data). Horizontal axis mm/sec, (-) down, (+) up direction. Notice that speeds cluster! Nice.

Solar-Flare

@solar-flare.activitypub.awakari.com.ap.brid.gy

6 months ago

Solar Mystery Cracked as Scientists Say Flares May Superheat Ions to 60 Million Degrees Scientists knew our Sun produced incredible temperatures, but new data says some solar flare particles are 6....

#Breaking #News #Physics #Science #Space #ions #solar […]

[Original post on thedebrief.org]

Oninvest

@oninvest.bsky.social

6 months ago

1/ 🧬 #IONS jumped 35% to a 4-year high after its drug Tryngolza (olezarsen) hit Phase III success — lowering triglycerides by ~70% and cutting pancreatitis attacks 85%.

StockTitan

@stocktitan.net

6 months ago

85% Reduction in Life-Threatening Pancreatitis: Ionis' Olezarsen Shows Historic Results in 1,100-Patient Trial Ionis' olezarsen achieves 72% triglyceride reduction and 85% fewer pancreatitis events in Phase 3 CORE studies. First-ever pancreatitis reduction in sHTG treatment, with 1,100 patients enrolled.

#IONS Olezarsen significantly reduces triglycerides and acute pancreatitis events in landmark pivotal studies for people with severe hypertriglyceridemia (sHTG)

www.stocktitan.net/news/IONS/olezarsen-sign...

StockTitan

@stocktitan.net

6 months ago

DAWNZERA™ (donidalorsen) approved in the U.S. as first and only RNA-targeted prophylactic treatment for hereditary angioedema Ionis Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration has approved DAWNZERA™ for prophylaxis to prevent attacks of hereditary angioedema in adult and pediatric patients 12 years of age and older. DAWNZERA is the first and only RNA-targeted medicine approved for HAE, designed to target plasma prekallikrein, a key protein that...

#IONS DAWNZERA™ (donidalorsen) approved in the U.S. as first and only RNA-targeted prophylactic treatment for hereditary angioedema

www.stocktitan.net/news/IONS/dawnzeratm-don...

Paul Arnheim-Projekt

@paula-projekt.bsky.social

7 months ago

My screenshot reads: "Water is a polar solvent. This means that polar substances, such as polar bears or most salts, dissolve in it. Water is a molecule consisting of two hydrogen atoms (H) and one oxygen atom (O). Because the two lone pairs of electrons in O take up a lot of space, the water molecule looks like a boomerang with O in the middle and is non-linear. O has a greater appetite for electrons than H. Therefore, it partially steals electrons from Hs, which causes the negative and positive charge centers to no longer align. Whenever this happens, a dipole is formed. There is a strong attraction between the opposite charges of the dipoles: opposite charges attract each other. The water dipoles do this too. Salts consist of positive and negative ions (wanderers in an electric field). When thrown into water, the oxygens of the water molecules cling to the positive cations, while the hydrogens are attracted to the negative anions."

Most Polar Bears are not polar: An Explanation
I used #ALText that makes text audible: #inclusion is fairness. And you kann use up to 8.3k characters in a single post!
#sharingisthenewlearning: fascinating #physics
#polarsolvent
#positive and #negative #ions: #kation and #anion
#charge #chargecenter

Faktaliya Media

@faktaliya.bsky.social

7 months ago

Quantum Control: Atoms Caught! 🧲 #quantum #ions #lasers 🎥 https://faktaliya.com/en.mp4