#Integrin

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins positione

1 month ago

Did you know @addgene.bsky.social now offers antibodies?

You can find 200+ #antibodies in their catalog — including IPI recombinants targeting #Netrin, #PUNC, #DCC, #Neurexin, #Neuroligin, #Glypican, #Integrin and more.

Browse here:

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STEMCELL Science News

@stemcellsciencenews.com

2 months ago

#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders.

A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.

https://go.nature.com/4aiBN2P

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3 months ago

Regulation of cell dynamics by rapid #integrin transport through the biosynthetic pathway. New study from Martina Lerche, Mathilde Mathieu, Johanna Ivaska @johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social and colleagues: rupress.org/jcb/article/...

#Adhesion #Cancer

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@huveneerslab.bsky.social

3 months ago

Xingchen Li, Christoph Ballestrem, et al. @mcrcellmatrix.bsky.social show that multidomain interactions between talin and tensin3 regulate #integrin activity, fibrillar #adhesion formation, #fibronectin assembly, and mechanosensitive tensin3 phase separation. rupress.org/jcb/article/...

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@genomerx.bsky.social

5 months ago

Novus Biologicals CD41/CD61 Antibody (PAC-1) Alexa Fluor 594 | Platelet Activation | GenomiRX YouTube video by Genomi Rx

www.youtube.com/watch?v=uJO6... Novus Biologicals CD41/CD61 Antibody (PAC-1) Alexa Fluor 594 | Platelet Activation | GenomiRX @NovusBio.bsky.social #CD41 #CD61 #PAC1 #NBP262201AF594 #AlexaFluor594 @genomirx.bsky.social #PlateletActivation #Integrin #GPiibIIIa #ThrombosisResearch

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@genomerx.bsky.social

5 months ago

Novus Biologicals CD41/CD61 Antibody (PAC-1) Alexa Fluor 594 | Platelet Activation | GenomiRX YouTube video by Genomi Rx

www.youtube.com/watch?v=uJO6...
@Novusbiologicals.bsky.social @genomirx.bsky.social #CD41 #CD61 #PAC1 #NBP262201AF594 #AlexaFluor594 #GenomiRX #PlateletActivation #Integrin #GPiibIIIa #ThrombosisResearch #Hemostasis #CardiovascularBiology #FlowCytometry #Immunofluorescence #BiomedicalResearch

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Stephan Huveneers

5 months ago

The integrin odyssey – a journey full of fundamental discoveries Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.

The integrin odyssey – a journey full of fundamental discoveries url: journals.biologists.com/jcs/article/...

Great to start the day while reading this #integrin odyssey.

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Fundamental and Clinical Pharmacology Journal (SFPT)

@fcp-sfpt.bsky.social

5 months ago

Fundamental & Clinical Pharmacology: Vol 39, No 5 Click on the title to browse this issue

FCP October issue now available!

#SFPT #pharmacology #fundamental #clinical #drug #rat #statin #cholesterol #heart #repurposing #pharmacokinetic #antibiotic #cancer #anxiety #brain #therapeutic #neural #cisplatin #genitourinary #integrin #cell

onlinelibrary.wiley.com/toc/14728206...

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Glypican antibody collection Glypicans are a family of highly conserved proteoglycans crucial for regulating cell signaling during development. Researchers rely on glypican antibodies to st

7 months ago

Looking for #glypican, #integrin or #epitopetag antibodies? Browse our #antibody catalog and order today ➡️➡️
proteininnovation.org/glypican-ant...

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@immunoeditor.bsky.social

7 months ago

Nice article from @xinruw.bsky.social & David Baker @uwproteindesign.bsky.social w/IPI cofounder Timothy Springer and others. They engineered a de novo #miniprotein, #NeoNectin, that could enhance cell attachment & spreading through binding with #integrin α5β1 ➡️

pubmed.ncbi.nlm.nih.gov/40489013/

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Seth Thomas Scanlon

8 months ago

PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance PSGL-1 acts as a phagocytosis checkpoint to promote tumor immune escape through impeding LFA-1 activation in macrophages.

New in #Science #Immunology: Researchers at Sun Yat-Sen University in Guangzhou report that #BloodCancers expressing PSGL-1 can prevent the #integrin signaling #macrophages need for #phagocytosis. Targeting PSGL-1 improved survival in mouse models of #leukemia, #lymphoma, & #MultipleMyeloma!

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Nature Cell Biology

@natcellbio.nature.com

9 months ago

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

☕Conway et al. show that #integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadopodia formation and invasion of #BreastCancer cells.
bit.ly/4n4v3JS

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Protein tools IPI is proud to provide high-quality, well-validated recombinant antibodies and other protein tools to the biological research community. We prioritize difficul

9 months ago

Working with #integrin or #glypican antibodies? Need a reliable plasmid or #antibody build to target #epitopetags? View our catalog and order IPI antibodies through @addgene today! proteininnovation.org/protein-reso...

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FEBS Letters

@febsletters.bsky.social

10 months ago

How does the #cytoskeleton control #BCR and #integrin signaling? Pethe & Hartmann give insights into healthy #Bcells and #CLL 🧫

➡️ doi.org/10.1002/1873-3468.70045

#signaling #bcellbiology #biomechanics

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10 months ago

Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. rupress.org/jcb/article/...

📕 In Immune Cell Biology 2025: rupress.org/jcb/collecti...
#AAI2025

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Protein tools IPI is proud to provide high-quality, well-validated recombinant antibodies and other protein tools to the biological research community. We prioritize difficul

10 months ago

Did you know IPI has #antibodies and #proteintools available? Take a look at our catalog, now including #glypican, #integrin and #epitopetag antibodies! proteininnovation.org/protein-reso...

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Isaac Li

@isaacli.bsky.social

10 months ago

Quantitative Super‐Resolution Imaging of Molecular Tension Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super-resolution by exploiting force-dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tensi....

Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion

doi.org/10.1002/advs...

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Gregor lab

@gregorlab.bsky.social

11 months ago

Excited to share our new @elife.bsky.social in collaboration with @Schiller lab.: Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis doi.org/10.7554/eLif...

#ECMatrix #chaperone #Clusterin #ECMresearch #Collagen #Integrin #AFM #Proteomics

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Isaac Li

@isaacli.bsky.social

1 year ago

We just published a review of the very recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd....
#mechanobiology #integrin #tensionprobes

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@mikhajlov-oleg.bsky.social

1 year ago

Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://buff.ly/4jU4e9C

In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Oleg Mikhajlov

1 year ago

11/11
These findings have broad implications for understanding cell–cell interactions, such as those between immune cells and target cells.
#CellAdhesion #Mechanotransduction #Microtubules #Dynein #Integrin #IntegrinAffinity #FluidSubstrates #CellSpreading

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