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Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells Panzer et al. show that paracrine signals from beta and delta cells inhibit glucagon secretion from alpha cells by opening G protein-gated inwardly rectifying potassium channels. Loss of this inhibiti...

The human alpha cell's competence to secrete glucagon depends on paracrine inhibitory input from beta (serotonin [5-HT], γ-aminobutyric acid [GABA]) and delta (somatostatin [SST]) cells #islets www.cell.com/cell-reports...

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Check out this great feature of DREAM investigator Dr. Lucy Marzban and her incredible research on amyloid formation in diabetes 👏🔬 @chrimanitoba.bsky.social @uofmpharmacy.bsky.social #diabetes #research #islets

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TALK-2, a K+ channel associated with diabetes, controls human beta cell ER Ca2+ handling, promoting basal insulin release and limiting glucose-stimulated insulin secretion #BetaCells #Islets #DiabetesResearch

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Islets on Steam Take to the sky and reunite a fragmented world in this surprisingly wholesome metroidvania! Help Iko adventure across beautiful hand-painted islands, receive letters from a quirky cast of characters, ...

If you like games like #Silksong, but lack the time or the agility to get as far as you'd like, you are gonna LOVE this game #Islets! Super cute, super fun, not too long, and if you're lucky/good, you can one-shot a boss on a 1st try!!! (yes, I play on easy)

#videogames #metroidvania #gaming

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The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion - Diabetolo... Aims/hypothesis The two-pore domain K+ channel TWIK1-related alkalinisation-activated K+ channel 2 (TALK-2) is encoded by KCNK17, which is one of the most abundant beta cell K+ channel transcripts tha...

The diabetes-associated K+ channel TALK-2 controls human beta cell endoplasmic reticulum Ca2+ handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1... 🔓

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The emerging role of pancreatic exocrine fibrosis as a common aetiological driver of islet dysfunction and diabetes: opportunities for novel disease-modifying interventions - Diabetologia Three diseases primarily affecting the exocrine pancreas—chronic pancreatitis, cystic fibrosis and pancreatic ductal adenocarcinoma—are all associated with a high incidence of diabetes. Together, they...

A spotlight on pancreatic exocrine fibrosis and #T2D @diabetologiajnl.bsky.social
link.springer.com/article/10.1... #islets

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Dowdy Lake, Colorado.

#photography #photo #nature #cloudscape #sky #skygazing #lake #water #hail #clouds #islets

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New findings on the link between ER stress and beta cell proliferation #BetaCells #Islets #DiabetesResearch

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In ZFDM rats, only males develop type 2 diabetes. This study shows that estradiol suppresses diabetes onset and shifts pancreatic islet gene expression toward a non-diabetic state.
Yokoi et al. 2026 DOI: 10.1538/expanim.25-0122
#Type2Diabetes #SexDifferences #Islets

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Islets does not have a fishing minigame, but it does have *bone fish*!!

#islets #indiegame #gaming #videogames #fishing #fishingminigame

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We'll be continuing #Islets tonight!! We're about 50% of the way through but we might not finish it tonight!!
www.twitch.tv/toothlessmoo...

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🤔 Ever wondered how tiny miRNAs shape #βCell #insulin release in #Type2Diabetes? New iScience research maps miRNA-mRNA networks in human #islets & spots key players like miR-101-3p linked to secretion pathways 🚀

🧾 www.cell.com/action/showP...

#miRNA #DiabetesGenomics #Endocrinology #CellBiology

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Starting a new metroidvania today called #Islets!! Made by the same people that made #CryptCustodian!! Let's see what this game is all about, shall we?!
www.twitch.tv/toothlessmoo...

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Acute and resolving inflammation differentially regulates beta cell function in mice via interactions between peritoneal and islet-associated macrophages - Diabetologia Aims/hypothesis Islet-associated macrophages regulate beta cell function during inflammation and tissue repair, but evidence for their role during metabolic adaptation and its failure is more limited....

Macrophages within islets and the peritoneum interact to regulate beta cell function during peritonitis and type 2 diabetes #T2D #DiabetesResearch #BetaCells #Islets link.springer.com/article/10.1...

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Studies in mice and human #islets identify JNK3 as a regulator of β cell function and survival and suggest that targeting this pathway may enhance incretin-based therapies www.jci.org/articles/vie...

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A detailed high resolution analysis looking at the cellular effects of biased GLP-1R agonism #islets @imperialcollegeldn.bsky.social www.sciencedirect.com/science/arti...

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Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells - Nature Communications Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacem...

PPARα-dependent mitochondrial programming promotes the differentiation of SC-β cells and may be a promising target to improve β cell replacement efforts for #T1D #stemcells #islets
www.nature.com/articles/s41... 🧪

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3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes - Nature Communications LSFM imaging revealed 3D islet maps: GADA+ cases mirrored controls, while short-duration T1D showed loss of small INS + GCG– islets but preserved larger mixed INS + GCG+ ones, highlighting islet size-...

High definition imaging suggests that the size and cellular composition of pancreatic #islets may, therefore, represent influential factors that impact β-cell loss during #T1D disease progression. www.nature.com/articles/s41...

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GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function - Nature Communications Following its internalisation, active endosomal GLP-1R engages with VAPB and SPHKAP at ER membrane contact sites to assemble a local cAMP/PKA condensate for the control of MICOS complex phosphorylatio...

New from The Tomas Lab Key pathways linking GLP-1R signaling to regulate β-cell mitochondrial remodelling and function #islets #diabetes www.nature.com/articles/s41... @tomaslab-imperial.bsky.social

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Protein Kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions Insulin secretion from pancreatic β-cells is essential for maintaining glucose homeostasis and preventing type 2 diabetes, a condition closely associa…

Studies in mice highlight the importance of PKD in preserving β-cell function under aging and metabolic stress conditions #islets #diabetes www.sciencedirect.com/science/arti...

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Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...

How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓

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The Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves #betacell function in stem cell-derived #islets under metabolic stress. #T1D #SC-islets #CellTherapy

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The peptide hormone spexin restores beta cell function by targetting the islet beta cell sodium–potassium pump in a mouse model of #diabetes #DiabetesResearch #Islets #BetaCells

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Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium–potassium pump - Diabetologia Aims/hypothesis Clinical studies revealed that serum spexin level is positively associated with beta cell function. However, the role of spexin in beta cells remains unclear. We hypothesise that spexi...

Spexin targets islet beta cell sodium–potassium pump to increase insulin secretion and beta cell mass, leading to a decrease in glucose levels in diabetes mouse model. #DiabetesResearch #Islets #BetaCells link.springer.com/article/10.1... 🔓

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GLP-1 blood sugar regulation in islet transplants • @1MEMO 20251114 Poster 13th Workshop of the AIDSPIT Study Group , Igls (Austria) January 23–25, 1994• Digitally remastered by author, publisher, M.P.M. van der Burg • Miracles•Media • 20251114 • TakeNode 810cc881-…

GLP-1 blood sugar regulation in islet transplants • @1MEMO 20251114 • Poster 13th Workshop of the AIDSPIT Study Group , Igls (Austria) January 23–25, 1994 #GLP1 #diabetes #islets #transplant michelvanderburg.com/2025/11/14/g...

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kiki_strider - Twitch Hiya everyone!I'm a wife, mom and lover of gaming (especially JRPGs, RPGs and MMOs *coughs* so much Final Fantasy). When I'm not juggling family life, you'll find me online probably getting super emot...

Happy Friday!
We're gonna start with a couple hours of our FFXIV Fresh Character, Full Clear Day 6! Wanna get our Limsa classes to 15 and maybe to Ul'dah. Thennnn...first time playthrough of Islets? O.O
Starting in 1 hr: from 10am-2pm MST!
#FFXIV #islets #English #Vtuber
www.twitch.tv/kiki_strider

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ISLETS - PROBAMOS LA DEMO!! ¿MERECE LA PENA?
ISLETS - PROBAMOS LA DEMO!! ¿MERECE LA PENA? YouTube video by XKondorianoX

Regresamos con un nuevo primeras impresiones por el canal, hoy probamos la demo de #Islets un Indie/Metroidvania super divertido. Espero que os guste 🤟

#playstation #gameplay #youtube

www.youtube.com/watch?v=-1V9...

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Adaptive mechanisms in pancreatic islets involve remodelling of defective cardiolipin, counteracting mitochondrial dysfunction in #BarthSyndrome #Islets #BetaCells #DiabetesResearch

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Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice - Diabetologia Aims/hypothesis Fetal programming of metabolic health is influenced by the in utero environment. The placental nutrient sensor mechanistic target of rapamycin (mTOR) is implicated in regulating fetal ...

A novel in vivo model of direct placental mTOR-driven fetal growth restriction provides evidence linking placental dysfunction and amino acid transport to early-life beta cell programming #T2D #Islets #DiabetesResearch link.springer.com/article/10.1... 🔓

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Congratulations Mariana J García, MBE on a successful thesis proposal defense! Now officially a PhD candidate! Excited to see your final thesis work #T1D #islets #stemcells #IMM UTHealth Houston Rice University

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