#KidneyInt

BioMassSpec

@realbiomassspec.bsky.social

4 months ago

Metabolic heavyweight: thick ascending limb or proximal tubule? Next round In this issue of Kidney International, investigators define the thick ascending limb as the most metabolically active cell in the kidney using a combination of single-cell techniques and mass spectrom...

Metabolic heavyweight: thick ascending limb or proximal tubule? Next round #KidneyInt #MassSpec www.kidney-international.org/article/S008...

Hao Yin

@haoyin.bsky.social

7 months ago

Non-hepatic #PCSK9

PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells

Megalin mediates PCSK9 uptake in renal epithelium

PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria

#KidneyInt 2023
www.sciencedirect.com/science/arti...

BioMassSpec

@realbiomassspec.bsky.social

9 months ago

Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biops... Membranous Nephropathy (MN) is characterized by subepithelial deposition of immune complexes along the glomerular basement membrane. The muscle-type phospholipase A2 receptor (PLA2R) has been identifi...

Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biopsy #KidneyInt #MassSpec www.kidney-international.org/article/S008...

Jen Li

@drjenkidney.bsky.social

1 year ago

www.kidney-international.org/article/S008...

#KidneyInt #BK

BioMassSpec

@realbiomassspec.bsky.social

1 year ago

In Situ molecular profiles of glomerular cells by integrated imaging mass spectrometry and multiplexed immunofluorescence microscopy #KidneyInt www.kidney-international.org/article/S008...

Hao Yin

@haoyin.bsky.social

1 year ago

Fibrillar collagen probe CNA35-Cy7 i.v. to monitor mouse kidney #Fibrosis (ischemia-reperfusion injury)

Can it be used for other organs in vivo?😄

#KidneyInt 2020
www.sciencedirect.com/science/arti...

Hao Yin

@haoyin.bsky.social

1 year ago

NONO protects SM22+ Arterial #SmoothMuscleCell from #Calcification Osteogenic reprogramming in🐭(5/6 Nephrectomy/Adenine diet/VitD)

BMP2 as a direct transcriptional (repressive) target gene of NONO (Any other NONO targets?🧐)

#KidneyInt 2024
www.sciencedirect.com/science/arti...

Hao Yin

@haoyin.bsky.social

2 years ago

GATA6 as a pro-calcific/pro-senescent factor in #SmoothMuscleCell
via ⏬ATM->⏫DNA dmg

AAV9-SM22α-GATA6 shRNA⏬VitD3-induced 🐭#AorticCalcification+#SMC #Senescence

#SIRT6 deacetylates+destabilizes NKX2.5 protein->⏬GATA6 transcription

#KidneyInt 2023
www.sciencedirect.com/science/arti...