#LDLR

@mol-biomed.bsky.social

3 months ago

Computer-aided design enables repurposing of proprotein convertase subtilisin/kexin type 9 degrader from cholesterol-lowering to colon cancer therapy - Molecular Biomedicine Molecular Biomedicine -

#Letter
omputer-aided design enables #repurposing of proprotein convertase subtilisin/kexin type 9 degrader from #cholesterol-lowering to colon #cancer therapy doi.org/10.1186/s435...

#ColorectalCancer #CRC #PCSK9 #LDL #LDLR #EMT

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European Journal of Human Genetics

@ejhg-journal.bsky.social

7 months ago

Novel start codon variant in the 5’UTR of LDLR associated with familial hypercholesterolaemia - European Journal of Human Genetics European Journal of Human Genetics - Novel start codon variant in the 5’UTR of LDLR associated with familial hypercholesterolaemia

🚨 New research alert! 🚨 A novel start codon variant in the 5’UTR of LDLR linked to Familial Hypercholesterolaemia, disrupting translation. Expanding the scope of FH genetic screening! 🧬🔬 #Genetics #FH #LDLR #EJHG

www.nature.com/articles/s41...

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American Journal of Preventive Cardiology

@ajpcardio.bsky.social

9 months ago

🧬 New: Sex & racial differences found in the prevalence + clinical traits of LDLR & PCSK9 FH variants, per All of Us Research data.

📖 Read: www.sciencedirect.com/science/arti...

#FH #LDLR #PCSK9 #CardioSky #MedSky #CVDPrevention #HealthEquity #ASPC

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Science Magazine

@science.org

1 year ago

Extracellular proximal interaction profiling by cell surface–targeted TurboID reveals LDLR as a partner of liganded EGFR A modified form of TurboID identifies extracellular interactions between transmembrane proteins.

In a new #ScienceSignaling study, researchers introduce extracellular #TurboID, a refinement of the popular proteomics tool that interrogates #ProteinProteinInteractions on the exterior cell membrane, and characterize interactions between #EGFR and #LDLR. scim.ag/3DgfJr9

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Posts tagged #LDLR