#MetabolicEngineering

@byteandpieces.bsky.social

5 days ago

This 'Resistant Starch' Hack Mimics a 48-Hour Fast (EAT CARBS!) Stop Starving. Start Engineering. What if everything you knew about carbs was a lie? Imagine melting visceral fat while eating potatoes and pasta—no starvation required. In this episode, we dive into the Easy Mode Carb Protocol, the ultimate Metabolic Engineering breakthrough that mimics a 48-hour fast without the physical stress of misery. We reveal how to master Metabolic Flexibility by turning simple starches into Resistant Starch, the powerhouse fuel for Bifidobacterium adolescentis that triggers GLP-1-like fat oxidation naturally. In this episode, you will learn: - The Acetic Acid Hack: How to build an 'acid shield' against insulin spikes using simple vinegar sequencing. - Fibermaxxing Secrets: Why the 'cook-cool-reheat' method is the 2025 secret to gut microbiome weight loss. - The Glucose Sponge Walk: Why a 10-minute stroll beats hours of high-intensity cardio for clearing blood sugar. - Butyrate Production: How to feed the specific bacteria linked to rapid visceral fat loss. Look, we've all been there—the keto burnout, the intermittent fasting wall, and the exhaustion of high-intensity dieting. It’s time to stop fighting your biology and start hacking it. 🚀 If you’re looking for a science-backed Ozempic Alternative that focuses on hormonal alignment and Insulin Sensitivity Hacks, this is your blueprint. Ready to transform your metabolism from the inside out? Hit subscribe, leave a review, and join the metabolic revolution today! ✨  

📣 New Podcast! "This 'Resistant Starch' Hack Mimics a 48-Hour Fast (EAT CARBS!)" on @Spreaker #aceticacid #biohacking #butyrate #easycarbs #fastingmimicking #fatloss #fibermaxxing #glp1 #glucosehack #guthealth #healthtips #insulinresistance #metabolicengineering #metabolicflexibility

Martin Grininger

@m-grininger.bsky.social

1 month ago

With our research, we are one step closer to biotechnological palm oil alternatives 🌱
rdcu.be/e2nbH

📺📻 Featured on TV, radio, and online media, e.g.:
www.tagesschau.de/inland/regio...

#Sustainability #GreenBiotechnology #Biotechnology #SyntheticBiology #MetabolicEngineering #PalmOil #PalmOilFree

Nediljko (Ned) Budisa

@nedbudisa.bsky.social

1 month ago

Novel genomically engineered antibiotic-free whole-cell biocatalysts for PET hydrolysis and waste remediation Plastic pollution is an escalating environmental challenge requiring stable and sustainable biotechnological solutions. Here, we report a major advanc…

Plastic as an “alien” carbon source!
Why plastic? It’s a chemically “alien” carbon source - far outside natural metabolism. That makes it the perfect testbed for synthetic cells with rewired genetic and metabolic logic.
#SyntheticCells #Xenobiology #MetabolicEngineering

LBVpam

@lbvpam.bsky.social

1 month ago

Beyond Tanacetum cinerariifolium: Advances in Pyrethrins Biosynthesis and Prospects for Engineered Cell Factories - Molecular Biotechnology Pyrethrins are powerful natural insecticides traditionally extracted from the flowers of Tanacetum cinerariifolium. While effective and environmentally friendly, their agricultural production is limit...

[📰 Paper] Beyond 𝑇𝑎𝑛𝑎𝑐𝑒𝑡𝑢𝑚 𝑐𝑖𝑛𝑒𝑟𝑎𝑟𝑖𝑖𝑓𝑜𝑙𝑖𝑢𝑚: Advances in Pyrethrins Biosynthesis and Prospects for Engineered Cell Factories

@cnrs.fr @cnrs-rhoneauvergne.bsky.social @htsbiotechmoss.bsky.social

#Pyrethrins #Metabolicengineering #Cellfactories #MEP #paper #plants

Theobald Smith Society

@njmicrobe.bsky.social

2 months ago

Lighting the Path to Neofunctionalization: Tuning Yeast Evolution with OptoRep The pursuit of rapid, targeted protein evolution has been significantly advanced by systems like OrthoRep, which allows for high-rate in vivo hypermutation of specific genes in Saccharomyces cerevisia...

Princeton's OptoRep, a system combining OrthoRep's hypermutation with optogenetic precision. Blue light controls essential metabolism, fine-tuning selection pressure, enabling de novo neofunctionalization. go.njmicrobe.org/9M8ssQ #Microbiology #MetabolicEngineering #Optogenetics #ContinuousEvolution

Saccharomyces Genome Database

@yeastgenome.bsky.social

3 months ago

#Yeast biodiversity + #MachineLearning enable strain/pathway design in other yeasts #MetabolicEngineering

S. cerevisiae
✅genetic tractability
✅robust growth
❌industrial biotech

Y. lipolytica/O. polymorpha
✅thermo/acid resistance
✅amass lipids
❌ genetic tools

www.yeastgenome.org/reference/S1...

Julian Verdonk

@julianverdonk.bsky.social

3 months ago

Model-guided metabolic engineering of 2-phenylethanol in Arabidopsis 2-Phenylethanol (2-PE) is a natural aromatic compound with properties that make it a potential biological oxygenate for petroleum-derived gasoline. In…

Arabidopsis can be engineerded to smell as a rose! @nickdesnoyer.bsky.social and @atinygreencell.bsky.social that means we can also make it smell as a #Petunia!! #MetabolicEngineering #plantscience

www.sciencedirect.com/science/arti...

MibiNet

@mibinet.bsky.social

3 months ago

Elucidating the itaconic acid pathway dynamics in Saccharomyces cerevisiae Itaconic acid, a versatile platform chemical, has garnered significant attention due to its broad use in polymers, resins, and bio-based materials. Al…

New MibiNet paper published! Engineered yeast for itaconate synthesis. Investigated transport between mitochondria, cytosol, and environment. Details here!
www.sciencedirect.com/science/arti...
#MibiNet #Yeast #MetabolicEngineering

Journal of Integrative Plant Biology

@jipb.bsky.social

3 months ago

🍅 Too good to save for #TomatoTuesday! Some great #PlantScience and #MetabolicEngineering of steroidal glycoalkaloids in tomato. @wileylifesci.bsky.social 🍅

BioDesign Research

@biodesignresearch.bsky.social

4 months ago

Comprehensive review explores C. glutamicum metabolic engineering for diverse biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories
Details: doi.org/10.1016/j.bidere.2025.100008

BioDesign Research

@biodesignresearch.bsky.social

4 months ago

Comprehensive review on C. glutamicum metabolic engineering for diverse substrates & biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories #Corynebacterium
Details: doi.org/10.1016/j.bidere.2025.100008

jiVoice

@jivoice.bsky.social

4 months ago

What is Synthetic Biology? A Guide to Engineering Life Imagine a world where we could program living cells the way we program computers. A world with bacteria that produce clean fuel from sunlight, yeasts that brew life-saving medicines instead…

What is Synthetic Biology? A Guide to Engineering Life #livingmachines #geneticengineering #biologicalsystems #syntheticbiology #customDNA #bioengineering #designinglife #CRISPR #DNAsynthesis #metabolicengineering

GetNews.me

@getnews-me.bsky.social

5 months ago

DeepGDel: Deep Learning Enhances Gene Deletion Design

DeepGDel, a new deep‑learning framework, improves gene‑deletion design accuracy by up to 22.52% compared with traditional methods, aiding growth‑coupled strain engineering. Read more: getnews.me/deepgdel-deep-learning-e... #deepgdel #metabolicengineering

Rita Clare

@scivetica.bsky.social

5 months ago

New back cover out this week in @greenchemistry.rsc.org for Lahiru Jayakody et al. at SIU Carbondale. P. putida was engineered to efficiently convert caffeine to 7-MX, a compound for treating myopia.
#greenchemistry #metabolicengineering #biochemistry #microbiology #scientificillustration

BioDesign Research

@biodesignresearch.bsky.social

6 months ago

Yarrowia lipolytica boosts terpene synthesis via synthetic biology! #Biofuels #MetabolicEngineering
Details: doi.org/10.34133/bdr.0046

Pablo Ivan Nikel

@pabnik.bsky.social

6 months ago

Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!

BioDesign Research

@biodesignresearch.bsky.social

6 months ago

Corynebacterium glutamicum engineering advances for diverse biochemical production! #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008

PuckerLab publications

@puckerlabpapers.bsky.social

7 months ago

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...

#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData

Pablo Ivan Nikel

@pabnik.bsky.social

8 months ago

Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic…

Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social
www.sciencedirect.com/science/arti...

BioDesign Research

@biodesignresearch.bsky.social

9 months ago

ALE & metabolic engineering boost SA production from glycerol in E. coli. Sustainable biodiesel byproduct utilization! #BiodieselByproducts #SAproduction #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100022

BioDesign Research

@biodesignresearch.bsky.social

9 months ago

C. glutamicum metabolic engineering expands substrates & products. Challenges & future directions explored! #CorynebacteriumGlutamicum #CellFactories #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008

Rémi Hocq, PhD

@remihocq.bsky.social

10 months ago

A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide - Nature Communications Carbon monoxide (CO) present in syngas severely inhibits growth of many acetogens. Here, the authors adapt, characterize, and engineer utilization of CO as sole carbon and energy source by the thermop...

We evolved T. kivui to grow fast on CO (doubling time ~2.8 h). The trick? A megatransposon rewired its redox and metabolic circuits.
#Transposons: not just genetic noise, but engines of innovation!
Full story: doi.org/10.1038/s414...

#Biotechnology #Extremophiles #MetabolicEngineering

Rémi Hocq, PhD

@remihocq.bsky.social

10 months ago

Our work opens the door to real #MetabolicEngineering in T. kivui.

It grows fast on CO₂ (∼2 h doubling time) with high carbon efficiency—ideal for sustainable fuel and chemical production.

With rapid, iterative genome editing now possible, these applications are within reach!

2/2

Nair (Synthetic Biology & Systems Bioengineering) Lab @Tufts

@nair-lab.bsky.social

10 months ago

The Nair lab is looking for a #post-doc experienced in yeast pathway and genome engineering. Please DM or email me if you are interested!! Please spread the word! #synbio #metabolicengineering

SUN-PERFORM

@sunperform.eu

11 months ago

One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle - Nature Microbiology An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.

Our partners @w-u-r.bsky.social and @mpimicrobiomarburg.bsky.social demonstrated how synthetic metabolism can outperform the Calvin cycle—nature’s mechanism for CO2 fixation.

Read the full, open-access Nature Microbiology article at doi.org/10.1038/s415...

#SyntheticBiology #MetabolicEngineering

MSK Library

@msklibrary.bsky.social

11 months ago

Featured today by @MSKLibrary: Metabolic engineering to facilitate anti-tumor immunity

#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism

www.sciencedirect.com/science/arti...

Doc Z

@effezeta84.bsky.social

11 months ago

And more #metabolicengineering for lignans biosynthesis #chembio

Doc Z

@effezeta84.bsky.social

11 months ago

A nice #metabolicengineering for renewable plastics from Sang Yup Lee’s group

@labnikel.bsky.social

1 year ago

..and fine tuning between endogenous activities and novel functions implemented by #metabolicengineering. A story - now available in preprint - brilliantly led by our Oscar! 💪

Gerrich

@gerrich.bsky.social

1 year ago

A new Zymomonas mobilis platform strain for the efficient production of chemicals - Microbial Cell Factories Background Zymomonas mobilis is well known for its outstanding ability to produce ethanol with both high specific productivity and with high yield close to the theoretical maximum. The key enzyme in t...

Another thesis paper post:

Engineering of a new platform strain of Z. mobilis for chemical production utilizing a metabolic flux valve.

We achieved specific productivity for lactate of > 90 mmol gCDW ^−1 h ^−1
#MetabolicEngineering #SynBio
doi.org/10.1186/s129...