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Posts tagged #Optogenetics

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions Scientists at the Ecole Polytechnique Fédérale de Lausanne have developed a novel method called 'optovolution' that uses light to guide the evolution of proteins with dynamic behaviors. Unlike traditional directed evolution, which favors proteins that remain constantly active, optovolution allows proteins to switch between states in a controlled manner. Using engineered yeast cells, researchers made cell survival dependent on proteins switching at the right time. Light pulses were applied to force proteins to alternate between active and inactive states during the yeast cell cycle, creating a fast and automatic selection process for the best-performing variants. This approach generated new light-sensitive proteins capable of responding to multiple colors and improved existing optogenetic systems. Additionally, the team evolved a transcription factor that acts as a simple logic gate, activating genes only when two signals—a light and a chemical—are present simultaneously. Optovolution could transform synthetic biology, biotechnology, and fundamental research by enabling the design of smarter cellular circuits, multi-state protein behaviors, and color-specific optogenetic tools.

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#proteins #optogenetics #evolution

View full AI summary:

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We're expanding our Imaging & Lab Essentials range! 🔬

Our novel red shifted calcium indicator - BAPTA-AM Janelia Fluor® 549 - is ideal for use with multicolor imaging & optogenetics 👩‍🔬👨‍🔬

Try this great new product: ow.ly/wQ7y50YrHSS

#imaging #optogenetics #lifescience #lifesci #labsupplies

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We’ve launched the UK Vision Research Network to bring brilliant minds together across disciplines and institutions. This PhD prog gives students the opportunity to learn from two supervisors.

More here on our first collab 🔗 https://ow.ly/vz6B50YkVH1

#VisionResearch #VisionLoss #Optogenetics

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We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

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Cross-layer all-optical physiology permits neuron circuit mapping Cross-layer all-optical physiology provides an essential tool for directly probing functional connectivity and causal interactions within neuronal circuits—and achieves high-speed...

www.laserfocusworld.com/biolife-scie...
#neuro #imaging #optogenetics

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Klinische Endpunkte und translationale Herausforderungen - Die Ophthalmologie Background Optogenetic vision-restorative approaches have entered the clinical stage of development. Objective This article provides an overview of the current status of translation. It discusses spec...

Our new review article: clinical endpoints & translational challenges in #optogenetics for vision restoration. From patient expectations to #ClinicalTrial endpoints. First review to focus specifically on clinical perspective. doi.org/10.1007/s003...

#retina #GeneTherapy
@unimarburg.bsky.social

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OPTOVIEW-Study: Whats the patient's perspective?

Advanced #CHM or RP can permanently destroy photoreceptors. Researchers are developing vision-restoration strategies like #Optogenetics. In an interview study patients are invited to talk about their expectations, needs & rehab/assistive gaps. lindnerlab.de/index.php/ne... #RareDisease #GeneTherapy

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🤩 Whoa! Our image is on the Nature Magazine #Neuroscience cover! 🧠

🎨 Cover 🎨 illustrates new #optogenetics method PRIME as a path through an expansive “neural forest.” Researchers are carefully crawling through the forest and using flashlights (a metaphor for optogenetic neuronal control).

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Green-Light Optogenetic Control in ChR2 Mice ec4
Green-Light Optogenetic Control in ChR2 Mice ec4 MAFA is a transcription factor whose role in #skin muscles was unclear; this study shows that optogenetic activation of #MAFA-positive #panniculuscarnosus induces #skintwitching in mice. Read the…

Watch the twitching response upon optogenetic green-laser stimulation in CHR2 mice, highlighting the key role of MAFA activation in the in the panniculus carnosus
#Optogenetics #NeuromuscularPhysiology #Neuroscience #SensoryDisorders

www.youtube.com/shorts/3j3YQ...

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#optogenetics #light #green 💚✳️🐭
#PDX1 #insulin #NEUROD1 #GSK3 #hypoglicemia #pancreaticcancer #MODY #diabetes

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Green-Light Optogenetic Control in MAFA-Cre ChR2 Mice ec3
Green-Light Optogenetic Control in MAFA-Cre ChR2 Mice ec3 MAFA is a transcription factor whose role in skin muscles was unclear; this study shows that optogenetic activation of MAFA-positive panniculus carnosus induces skin twitching in mice. Read the…

Watch how optogenetic green-laser stimulation induces twitching in MAFA-cre-CHR2 mice, highlighting the potential role of MAFA in neuromuscular physiology.

#Optogenetics #NeuromuscularPhysiology #Neuroscience

www.youtube.com/shorts/vjYF8...

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Optogenetic Blue-Light Stimulation in ChR2 Mice ec2
Optogenetic Blue-Light Stimulation in ChR2 Mice ec2 MAFA is a transcription factor whose role in skin muscles was unclear; this study shows that optogenetic activation of MAFA-positive panniculus carnosus induces skin twitching in mice. Read the…

Control CHR2 mice show no twitching under blue-light stimulation, confirming that optogenetic activation of panniculus carnosus requires MAFA expression.
#Optogenetics #Neuromuscular #DermalPhysiology

www.youtube.com/shorts/5KdxP...

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Watch skin twitching in action!

In Video 1, optogenetic blue‑laser stimulation of MAFA‑cre‑CHR2 mice activates panniculus carnosus muscle, revealing a novel role for MAFA in cutaneous motor control.

#Neuroscience #Optogenetics: www.youtube.com/shorts/iIYGV...

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Optogenetic Trials

We have created an (exhaustive - we think) directory of interventional clinical trials on optogenetic visual restoration: lindnerlab.de/index.php/pu.... Hopefully a helpful resource for funders, researchers and regulators!

#retina #GeneTherapy #optogenetics
@unimarburg.bsky.social

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[2025 OPEN ACCESS]
Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording
2025 Appl. Phys. Express 18 026501

iopscience.iop.org/article/10.3...

#APEX
#OpenAccess
#Physics
#microLED
#GaN
#Optogenetics
#Neural
#probe
#modulation
#device
#process

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🔴⚡ When mitochondria light the way.

Joyce Chen (University of Chicago) uses optogenetics to trigger mitochondria-carrying extracellular vesicles—then tracks glowing red signals from one cell to another, live.

Seeing power&information transfer in real time.
#CMBE2026 #Optogenetics

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Developmental dopamine loss rewires striatal circuits to promote locomotion - Molecular Neurodegeneration Molecular Neurodegeneration - Motor symptoms of Parkinson’s disease (PD) primarily result from the degeneration of nigrostriatal dopaminergic neurons (DANs), particularly the Aldehyde...

Developmental #dopamine loss rewires striatal circuits to promote locomotion

Jie Dong...Weidong Le, Jun Jia, Huaibin Cai @NIHAging @NIH #Parkinsons #optogenetics

link.springer.com/article/10.1...

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(VIDEO) WEF World Economic Forum: Optogenetics – Blue Light Technology Brain Control
www.rekkrnation.com/2025/12/29/v...
#News #BreakingNews #Media #today #WEF #WorldEconomicForum #Optogenetics #BlueLightTechnology #BrainControl

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By Yafei Yuan, Guanghao Li, Haoran Ren & Wei Chen
Published April 19, 2021
#Phenomics #fNIRS #CognitiveScience #Neuroscience #BrainHealth #LightTherapy #StroopTask #Neuroimaging #PrefrontalCortex #HumanCognition #Bioengineering #Optogenetics #WorkplaceWellness #MentalPerformance #ResearchHighlight

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Graphical abstract

Evaluation of lipid nanoparticles as vehicles for optogenetic delivery in primary cortical neurons www.mdpi.com/1999-4923/18... #optogenetics, gene therapy without viruses; #BCI #NeuroTech

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Graphical abstract

Evaluation of lipid nanoparticles as vehicles for optogenetic delivery in primary cortical neurons https://www.mdpi.com/1999-4923/18/1/4 #optogenetics, gene therapy without viruses; #BCI #NeuroTech

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Lighting the Path to Neofunctionalization: Tuning Yeast Evolution with OptoRep The pursuit of rapid, targeted protein evolution has been significantly advanced by systems like OrthoRep, which allows for high-rate in vivo hypermutation of specific genes in Saccharomyces cerevisia...

Princeton's OptoRep, a system combining OrthoRep's hypermutation with optogenetic precision. Blue light controls essential metabolism, fine-tuning selection pressure, enabling de novo neofunctionalization. go.njmicrobe.org/9M8ssQ #Microbiology #MetabolicEngineering #Optogenetics #ContinuousEvolution

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DARPA's "Generative Optogenetics" Program Is All That We've Feared & Held Hostage By Geoengineering Welcome to The Daily Wrap Up, an in-depth investigatory show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours (12/17/25). As always, take the informat...

DARPA's "Generative Optogenetics" Program Is All That We've Feared & Held Hostage By Geoengineering www.thelastamericanvagabond.com/darpa-optoge... #TheDailyWrapUp #DARPA #Optogenetics #Magnetogenetics #Geoengineering

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We’re happy to welcome Feng Wang, professor at the Faculté de médecine dentaire of @ulaval.ca .

His research focuses on the cellular and molecular mechanisms that cause chronic and pathological #pain.

Learn more about Pr Wang 👉 zurl.co/hXNu9

#PainResearch #Neurosciences #Optogenetics

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Optogenetics controlled by generative AI... feels less “science” and more like unlocking a biological API. Potential is huge, oversight *needs* to be. 🤖 #optogenetics

DARPA GO: Generative Optogenetics

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Happy birthday to #LaskerLaureate Peter Hegemann! He was recognized with a #LaskerAward for his work on light-sensitive microbial proteins and #optogenetics. 🧪
ow.ly/39py50H4Kf0 @humboldtuni.bsky.social

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Various triggers e.g. touch, wounding, induce different Ca2+ signatures and electrical signals such as APs and slow wave potentials that are very likely processed by diverse Ca2+ decoders.

Various triggers e.g. touch, wounding, induce different Ca2+ signatures and electrical signals such as APs and slow wave potentials that are very likely processed by diverse Ca2+ decoders.

The power of #ionic movements in #plants

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#ResearchReview by Hedrich and Kreuzer

@WileyPlantSci #PlantScience #Optogenetics

Figure modified after Iosip et al. (2023).

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Taking advantage of #CellBio2025 returning to Philly this year. Plenty of cool kidney and kidney-adjacent projects to share from @hugheslabpenn.bsky.social!

Ronald Canlla is presenting our collaborative #optogenetics and #organoids work on Tuesday (B023, 12:45-2:15pm.) Come say hi!

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Zhongmou Wins U.S. FDA Clearance for China’s First Optogenetic Human Trials ZM-02 becomes the first China-origin optogenetic therapy authorized for U.S.

#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials www.linkedin.com/pulse/zhongmou-wins-us-f... using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM

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Zhongmou Wins U.S. FDA Clearance for China’s First Optogenetic Human Trials ZM-02 becomes the first China-origin optogenetic therapy authorized for U.S.

#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials www.linkedin.com/pulse/zhongm... using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM

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