Latest posts tagged with #MolBio on Bluesky
Ward, @drokyta.bsky.social et al. investigated the genetics of venom resistance using venom of the Florida blue centipede and Drosophila melanogaster as model prey, revealing a stark contrast in the nature of venom resistance between prey sexes.
🔗 doi.org/10.1093/molbev/msag048
#evobio #molbio
MBE | Large-scale genomic phylogeography provides insights into evolutionary history and conservation priorities of the white-bellied pangolin (Phataginus tricuspis)
Gu et al. leveraged hundreds of genomes and mitogenomes of the African white-bellied pangolin, uncovering the evolutionary history of this species and indicating the need for urgent attention and priority conservation action.
🔗 doi.org/10.1093/molbev/msag049
#evobio #molbio
Potapenko et al. studied two species of barley, finding that TE silencing is central to genome size regulation, with selection maintaining smaller genomes among individuals with higher fitness in favorable habitats.
🔗 doi.org/10.1093/molbev/msag051
#evobio #molbio #TEsky #PlantSky
Molecular Biology and Evolution | March 2026 cover
The March cover of Molecular Biology and Evolution features the work of Leria and Maldonado, who investigated biosilicification and skeletal evolution in sponges.
Follow the link for this month's articles:
🔗 academic.oup.com/mbe/issue/43/3
#evobio #molbio #societyjournal
@sishuowang.bsky.social & Meade introduce phyloHessian, using complex mixture substitution models in molecular dating. Empirical analysis of ancient symbiont lineages leads to a revised understanding of their host association origins.
🔗 doi.org/10.1093/molbev/msag039
#evobio #molbio #compbio
🔄 Tiny, 45 base long RNA can make copies of itself
arstechnica.com/science/2026...
#rna #molecules #replication #molbio
Fontan et al. show that sequence divergence within introns can disrupt essential gene expression through defective splicing, providing a mechanistic link between rapid Y chr. evolution and hybrid sterility.
🔗 doi.org/10.1093/molbev/msag045
#evobio #molbio #drosophila
@jullienflynn.bsky.social
Zhu, @susumu31.bsky.social et al. present MitoNGS, a platform designed for high-resolution analysis of fish metabarcoding data that allows for fish detection, biodiversity monitoring, conservation research, and bioresource management.
🔗 doi.org/10.1093/molbev/msag046
#evobio #molbio
@jomcinerney.bsky.social proposes that genomes do not encode fixed functions but rather “probability distributions” over functional and phenotypic outcomes, and introduces “genomic perplexity” as a measure of gene-context incompatibility.
🔗 doi.org/10.1093/molbev/msag041
#evobio #molbio
MBE | Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues
@edmundotogo.bsky.social et al. studied de novo indel mtDNA mutations across multiple age groups in three mammalian species, showing that indels accumulate rapidly with age in somatic tissues with high energetic demand or high proliferation.
🔗 doi.org/10.1093/molb...
#evobio #molbio #mtDNA
@russcd.bsky.social ushers in a new era of academic metrics with the core-pivotal author index, which assigns all credit to authors that occupy the exact center of the author list, while non-central peripheral authors receive no credit whatsoever.
🔗 doi.org/10.1093/molbev/msag026
#evobio #molbio
MBE | The role of society journals in protecting the scientific record
MBE Editors-in-Chief Claudia Russo and Brandon Gaut publish a new editorial on the role of society journals in protecting the scientific record.
🔗 doi.org/10.1093/molbev/msag022
#evobio #molbio #societyjournal
@claurusso.bsky.social @bsgaut.bsky.social
Molecular Biology and Evolution A new look, the same rigor and commitment to the community
🙌 The new logo of Molecular Biology and Evolution is now live!
This new look will carry us forward while maintaining the same rigor and commitment to the molecular evolutionist community as an SMBE journal.
#evobio #molbio #science #biology #societyjournal
Ruckman & Long review how affordable sequencing is transforming complex trait research, focusing on how affordable sequencing has fundamentally reshaped what questions evolutionary researchers can ask and how they can answer them.
🔗 doi.org/10.1093/molbev/msag025
#evobio #molbio
MBE | The evolutionary genomics of meiotic drive Meiotic drivers gain transmission advantages by distorting equal, Mendelian segregation. This review discusses the evolutionary genomics of meiotic drive. The figure highlights the interactions of meiotic drive elements with other classes of selfish genetic elements including: direct interactions between drivers and transposable elements (TEs) (A) or satellites (C) that can facilitate the spread of drivers; other drive systems that cause the mutual destruction of all gametes (B; e.g. the presence of multiple toxin-antidote systems); indirect interactions where the host machinery responsible for silencing TEs are recruited to silence drivers (D); dosage-sensitive interactions involving sex-linked drivers that result in gene amplifications (E); and tradeoffs between suppressing drive and TEs (F).
For a new MBE Review, Presgraves et al. argue that many features of genome evolution, content, and organization seemingly inexplicable by adaptation or nearly neutral processes are instead best accounted for by meiotic drive.
🔗 academic.oup.com/mbe/article/...
#evobio #molbio
Collins et al. combined expression, methylation, and genomic data to investigate long-term persistence of laterally acquired genes in the grass Alloteropsis, showing that those capable of regulating their own expression are more likely to persist.
🔗 doi.org/10.1093/molbev/msag042
#evobio #molbio
Manneh et al. used flow cytometry and microscopy-based approaches to investigate whether P. falciparum parasites preferentially invade specific Duffy RBC phenotypes and explored two potential explanations for invasion preference
🔗 doi.org/10.1093/molb...
#evobio #molbio #malaria
MBE | Phylogenetic Analysis of NEAT1 and MALAT1 Long Non-Coding RNAs Highlights Structure–Function Relationships in Paraspeckle Biology
Arkhipova & Drukker identified orthologs of NEAT1 and MALAT1 - the only lncRNAs that use the tRNA-processing machinery for maturation - across 545 mammals to investigate differences in function and evolutionary conservation.
🔗 doi.org/10.1093/molbev/msaf265
#evobio #molbio
Deng et al. assembled the first chromosome-level reference genome for Daphnia obtusa and deep sequenced eight mutation-accumulation lines for ~500 generations, assessing the interplay among mutation, selection, and genome stability.
🔗 doi.org/10.1093/molb...
#evobio #molbio
MBE | Amhy/Amhr2y-mediated sex determination in two distantly related teleosts relies on the conserved Alk3-Smad5 axis
Zhou et al. establish Alk3 and Smad5 as essential and specific transducers of the Amhy/Amhr2-mediated sex-determination pathway, revealing a potentially conserved signaling axis across teleosts.
🔗 doi.org/10.1093/molbev/msag038
#evobio #molbio
MBE | Evolutionary remodeling of the FXR binding pocket drove functional divergence and ligand discrimination
Yamamoto, @cdokafor.bsky.social et al. used structural and functional analysis to identify the set of evolutionary substitutions that recapitulate the shift in ligand preference from the FXR/LXR ancestor to the ancestral vertebrate FXR.
🔗 doi.org/10.1093/molbev/msag031
#evobio #molbio
Tao et al. sequenced 14 ancient genomes from cave burial sites in Guangxi, revealing continuous gene flow from northern lineages into ancient cave burial populations.
🔗 doi.org/10.1093/molbev/msag034
#evobio #molbio #humanevolution
Robbins, Liu & Kelly present RECUR, a method for identifying recurrent amino acid substitutions from multiple sequence alignments that is fast, easy to use, and scalable to thousands of sequences.
🔗 doi.org/10.1093/molbev/msag036
#evobio #molbio #compbio
@dengziqi1991.bsky.social et al. present TreeProfiler, a tool for automated annotation and interactive exploration of hundreds of features along large gene and species trees, with seamless summarization of mapped traits at internal nodes.
🔗 doi.org/10.1093/molb...
#evobio #molbio #compbio
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
Wang et al. reveal that arboreality evolved independently in multiple snake clades, with tail elongation as a recurrent morphological adaptation, and identify accelerated evolution in genes associated with somite specification.
🔗 doi.org/10.1093/molbev/msag029
#evobio #molbio
Wu et al. performed scRNA-seq and meiotic analyses on germ cells and somatic cell subtypes of testes in cattle and yak, elucidating the molecular regulatory network involved in cattle spermatogenesis
🔗 doi.org/10.1093/molbev/msag027
#evobio #molbio
MBE | Genomic consequences of domestication and the diversification of body coloration and morphology in ornamental medaka strains
Kon et al. performed WGS on 181 individuals of 86 ornamental Japanese medaka strains, tracing their origin to the Kansai–Setouchi region, and uncovered 3,328 genes associated with 26 phenotypes.
🔗 doi.org/10.1093/molbev/msag021
#evobio #molbio #medaka
Kuang et al. present chromosome-level genome assemblies for subterranean zokor rodents, identifying two species-specific chromosomal fusions. Reduced gene flow on the fused chromosomes suggests a role in reproductive isolation.
🔗 doi.org/10.1093/molbev/msag032
#evobio #molbio
MBE | Viral Simulation Reveals Overestimation Bias in Within-Host Phylodynamic Migration Rate Estimates Under Selection
Ochsner et al. developed virolution as a tool to simulate the evolution of a virus within two anatomical compartments of a host; results reveal that commonly used phylogeographic methods can bias migration rate estimates in selective regimes.
🔗 academic.oup.com/mbe/article/...
#evobio #molbio
